Hruby Slovensky preklad titulkov pre program: BBC Horizon 2012 – Epizodu 03 – Eat, Fast And Live Longer (Jedz, pôsti sa a ži dlhšie):

Tu je cele video v horsej kvalite (Vimeo.com – 297MB):

BBC – Eat, Fast And Live Longer (Jedz, pôsti sa a ži dlhšie) from Jozef on Vimeo.

A tu to je v originalnej kvalite (DailyMotion.com – 769MB):

BBC – Eat, Fast And Live Longer (Jedz, pôsti sa… by jozef-zilina

A ak by chcel niekto upravit titulky, tu su ako v Slovencine, tak aj v Anglictine (akurat mi potom poslite novu kopiu v komentari alebo emailom):

—–

Slovenske Titulky:

1
00:00:07,040 –> 00:00:09,000
Milujem zivot,

2
00:00:09,000 –> 00:00:13,280
a preto chcem zostat mlady a energicky,
a uzivat si to tak dlho, ako to len pojde.

3
00:00:13,280 –> 00:00:15,480
Mam lekarsky trening.

4
00:00:15,480 –> 00:00:19,360
A som si vedomy vsetkych
odporuceni o tom ako mam zostat zdravy.

5
00:00:19,360 –> 00:00:23,120
Ale v mojom pripade to
nejako proste nefunguje.

6
00:00:24,760 –> 00:00:29,800
Zistil som, ze moje telo uz nie je
ten stihly a trvanlivy pristroj

7
00:00:29,800 –> 00:00:31,800
ktorym by som chcel aby bolo.

8
00:00:31,800 –> 00:00:37,480
Tretina vasho tela je tuk. Dakujem!
Ze ste to tak zroraznili.

9
00:00:37,480 –> 00:00:42,400
Chcel som vidiet, ci veda moze ponuknut
nejaky iny sposob, ako zastavit starnutie,

10
00:00:42,400 –> 00:00:44,560
spomalit hodiny,

11
00:00:44,560 –> 00:00:48,000
a tak som vyrazil najst odbornikov

12
00:00:48,000 –> 00:00:51,520
ktori sa snazia bojovat
proti starnutiu.

13
00:00:51,520 –> 00:00:54,760
Tu od zakladu prepisujeme ludsku
fyziologiu. Ooh … joj!

14
00:00:56,160 –> 00:01:00,440
Ak sa vam podari najst nieco ine, co
nebude boliet a bude mat tie iste vyhody,

15
00:01:00,440 –> 00:01:03,440
a bude sposobovat taketo uzasne
zmeny, rad by som o tom vedel.

16
00:01:05,160 –> 00:01:08,200
Co som zistil, bolo naozaj prekvapujuce.

17
00:01:09,800 –> 00:01:14,640
Nejedna sa o ziadne tabletky, ziadne
injekcie a nema to ziadne skryte naklady.

18
00:01:14,640 –> 00:01:17,400
Je to vsetko otazka len a len toho, co jete.

19
00:01:17,400 –> 00:01:19,400
Alebo lepsie povedane, toho co nejete.

20
00:01:20,920 –> 00:01:25,480
Vcera v noci sa mi snivalo ze som jedol sendvic
a potom som sa citil hrozne previnilo.

21
00:01:25,480 –> 00:01:26,840
Je to cele o poste.

22
00:01:26,840 –> 00:01:30,120
A ako sa postit co jednoduchsie!

23
00:01:30,120 –> 00:01:32,400
A ak by som isiel na Joe-ov zivotny styl…?

24
00:01:32,400 –> 00:01:36,200
Do roka budete uplne vylieceny!

25
00:01:42,480 –> 00:01:48,600
Velkou prednostou je, ze je to zaciatok
niecoho, co si myslim, ze by mohol byt velmi vyznamne.

26
00:01:48,600 –> 00:01:51,480
A ak sa to chyti a pojde v spravnom
smere… Viem si predstavit, ze to aj bude

27
00:01:51,480 –> 00:01:54,920
a moze byt
skutocne nieco revolucne.

28
00:02:10,840 –> 00:02:12,720
(Klakson)

29
00:02:18,520 –> 00:02:23,160
Existuje vela ludi, co
zostavaju relativne mladymi a fit

30
00:02:23,160 –> 00:02:25,160
aj po dosiahnuti dochodkoveho veku.

31
00:02:33,480 –> 00:02:36,320
Vacsinou to dosiahnu tradicnym sposobom –

32
00:02:36,320 –> 00:02:39,120
hlavne prostrednictvom cvicenia.

33
00:02:39,120 –> 00:02:42,280
Dnes som prisiel na Londynsky maraton.

34
00:02:42,280 –> 00:02:47,000
Takmer 36 tisic ludi
vsetkych tvarov a velkosti

35
00:02:47,000 –> 00:02:49,360
ktory sa snazia pokorit 42km dlhu trasu.

36
00:02:49,360 –> 00:02:51,480
Niektory z nich su mladici,

37
00:02:51,480 –> 00:02:53,400
vela znich vsak uz nie az tak mladych.

38
00:03:00,560 –> 00:03:03,920
Je tu uplne
fantasticka atmosfera.

39
00:03:03,920 –> 00:03:05,760
Doteraz som nikdy nebezal maraton

40
00:03:05,760 –> 00:03:08,560
a pravdu povediac, tiez nemam ziadne plany
niekedy maraton bezat,

41
00:03:08,560 –> 00:03:12,160
ale dneska tu je vela
ludi co bezat budu a

42
00:03:12,160 –> 00:03:15,160
su ovela starsi nez som ja sam.

43
00:03:15,160 –> 00:03:18,880
Je tu 7 tisic ludi nad 50 rokov

44
00:03:18,880 –> 00:03:21,480
a co je uplne neuveritelne,

45
00:03:21,480 –> 00:03:25,560
je tu sedem ludi, co su
starsi nez 80 rokov.

46
00:03:31,320 –> 00:03:35,280
Budem sa snazit
niektorych z nich

47
00:03:35,280 –> 00:03:37,200
opytat, ako to vlastne robia.

48
00:03:37,200 –> 00:03:39,560
Dobry den! Ako sa mate? Dobry den!

49
00:03:40,760 –> 00:03:42,720
Kolko mate rokov? 78.

50
00:03:42,720 –> 00:03:44,360
A kolko mate rokov vy? 81.

51
00:03:50,960 –> 00:03:54,280
Ake je tajomstvo?
Beh? Nie, kuzelna palicka :)

52
00:03:54,280 –> 00:03:57,520
Len dobre jest. Tvrdo
pracovat synak, to je vsetko!

53
00:03:59,120 –> 00:04:04,200
Kazdy, kto dokaze ubehnut maraton
v 70tke si zasluzi moju uctu,

54
00:04:04,200 –> 00:04:10,000
ale ja cakam na muza, pri ktorom
osemdesiatnici vyzeraju mlado.

55
00:04:13,920 –> 00:04:16,440
Fauja Singh je niekto uplne uzasny.

56
00:04:16,440 –> 00:04:19,120
Bol aktivny po cely zivot,

57
00:04:19,120 –> 00:04:22,800
a seriozne sa zacal venovat
behu az v jeho 80tke.

58
00:04:22,800 –> 00:04:27,640
Co to je, co ho drzi
tak pozoruhodne fit?

59
00:04:27,640 –> 00:04:31,200
Dobry den. Rad Vas vidim.

60
00:04:31,200 –> 00:04:34,080
Kolko rokov ma Fauja? 101.

61
00:04:34,080 –> 00:04:37,000
Narodil sa 1. Aprila 1911.

62
00:04:37,000 –> 00:04:41,000
Bohuzial nie este docela
zvladol anglicky jazyk.

63
00:04:41,000 –> 00:04:44,200
Nebude vam vadit, ak sa opytam ako sa citi?

64
00:04:44,200 –> 00:04:46,360
(Hovoria Pandzabsky)

65
00:04:49,440 –> 00:04:51,680
Povedal, “Nie je to az take lahke …” Ano?

66
00:04:51,680 –> 00:04:56,960
Ale chce dokoncit co zacal, a stale este
neskoncil. Nejdete to vzdat, ze nie?

67
00:05:02,840 –> 00:05:05,200
Aj ked ma 101 rokov,

68
00:05:05,200 –> 00:05:09,160
Fauja nikdy nebol na ziadnej operacii,

69
00:05:09,160 –> 00:05:13,440
nema ziadne priznaky akejkolvek choroby srdca …

70
00:05:13,440 –> 00:05:16,320
a neberie ziadne lieky.

71
00:05:20,160 –> 00:05:23,040
Veri, ze za jeho dlhu zivotnost

72
00:05:23,040 –> 00:05:26,240
a jeho neuveritelne zdravie
je zodpovedna hlavne jeho strava.

73
00:05:28,480 –> 00:05:30,680
Takze, nejaka specialna dieta?

74
00:05:30,680 –> 00:05:33,200
Nema ziadnu zvlastnu dietu.

75
00:05:33,200 –> 00:05:39,200
Je to jednoducha dieta Punjabskeho farmara
, cize len cerstve potraviny,

76
00:05:39,200 –> 00:05:42,080
ale jeho tajomstvom je, ze
jedava len mensie porcie. Vazne.

77
00:05:42,080 –> 00:05:45,040
V chudobnych krajinach,
ludia umieraju hladom.

78
00:05:45,040 –> 00:05:48,600
V bohatych krajinach,
ludia umieraju na prejedanie.

79
00:05:48,600 –> 00:05:52,080
Tak, ake velke su jeho porcie
, co ja viem, v porovnani s Vami, alebo mnou?

80
00:05:52,080 –> 00:05:55,120
On zje asi tolko co by bola
klasicka polovicna porcia,

81
00:05:55,120 –> 00:05:57,640
cize nieco co by sa dalo nazvat detskou porciou.

82
00:05:57,640 –> 00:06:02,000
Cize detska porcia je pravdepodobne asi polovica
mnozstva kalorii, ktoru by som ja, ci vy zjedli?

83
00:06:04,840 –> 00:06:08,720
Obmedzenim jeho prijmu
jedla tak dramaticky,

84
00:06:08,720 –> 00:06:12,960
Fauja nevedomky testuje
teoriu, ktora existuje

85
00:06:12,960 –> 00:06:15,280
skoro tak dlho, ako je sam nazive.

86
00:06:17,480 –> 00:06:21,680
Je to vedecka teoria, ktora vsak az
teraz naozaj vstupuje do povedomia!

87
00:06:26,920 –> 00:06:30,720
Vzal som si autobus az k cielovej ciare.

88
00:06:30,720 –> 00:06:33,760
Chcem zachytit ako sa Fauja stane, dufajme,

89
00:06:33,760 –> 00:06:36,960
najstarsim maratonskym bezcom na svete.

90
00:06:44,880 –> 00:06:49,800
A po siedmich hodinach a
49 minutach, uspel.

91
00:06:49,800 –> 00:06:52,920
(Fandenie a potlesk)

92
00:06:55,760 –> 00:06:58,280
Mozem vam pogratulovat?

93
00:07:12,440 –> 00:07:15,960
To je uplne neuveritelne
– Ma 101 rokov

94
00:07:15,960 –> 00:07:19,080
a prave dokoncil 42 kilometrov

95
00:07:19,080 –> 00:07:22,480
Absolutne si neviem predstavit
ze taketo nieco by som dokazal za 50 rokov odteraz,

96
00:07:22,480 –> 00:07:24,800
ja asi budem behat akurat tak po nakupnom stredisku,

97
00:07:24,800 –> 00:07:27,200
ale chcel by som byt takym ako je on.

98
00:07:27,200 –> 00:07:32,080
Chcem byt dusevne aktivny a fyzicky
aktivny, a chcem zostat mladsi co najdlhsiu dobu.

99
00:07:42,680 –> 00:07:45,960
Po desatrocia, timy
vedcov po celom svete

100
00:07:45,960 –> 00:07:49,000
intenzivne studovali starnutie.

101
00:07:49,000 –> 00:07:55,560
Vcelku jednoznacne, geny hraju dolezitu rolu
v tom ako rychlo a ako kvalitne starneme,

102
00:07:55,560 –> 00:07:58,760
ale co sa tyka genov,
so svojou situaciou moc spravit nemozete.

103
00:07:58,760 –> 00:08:03,000
Avsak, je tu nieco
co mozete urobit, s tym co jete.

104
00:08:06,880 –> 00:08:11,960
A tu v Amerike, sa zacinaju
ukazovat vysledky niektorych naozaj pozoruhodne vyskumov

105
00:08:11,960 –> 00:08:14,600
ktore spajaju jedlo s dlhovekostou.

106
00:08:14,600 –> 00:08:20,200
Zda sa, ze to nie je len o tom, co
jeme, ale ako a kedy jeme

107
00:08:22,040 –> 00:08:27,480
Nas pribeh zacina v zaprasenych
tanierocha a miskach Ameriky pocas 30tich rokov.

108
00:08:27,480 –> 00:08:30,600
Vtedy bolo strasne
sucho, jedlo bolo vzacne,

109
00:08:30,600 –> 00:08:34,760
a cela krajina bola v
pazuroch velkej depresie.

110
00:08:34,760 –> 00:08:37,480
Dokazeme si predstavit,
ze asi v tychto tazkych casoch,

111
00:08:37,480 –> 00:08:42,040
priemerna dlzka zivota musela
klesat, ale skutocnost je taka, ze naopak rastla.

112
00:08:44,440 –> 00:08:49,600
Pocas najtemnejsich rokov
velkej hospodarskej krizy – 1929 az 1933 –

113
00:08:49,600 –> 00:08:53,960
sa priemerna dlzka zivota zvysila
o vyznamnych 6 rokov.

114
00:08:59,320 –> 00:09:03,080
Takto povedane,
je to nieco prekvapujuce,

115
00:09:03,080 –> 00:09:08,760
ale naznaky preco tomu tak je, zacali byt
viditelne az z vyskumov situacie v 30tich rokoch.

116
00:09:09,920 –> 00:09:13,320
Odbornici na vyzivu na Cornell
Univerzite pracujuci so zvieratami

117
00:09:13,320 –> 00:09:15,720
zistili, ze ak vazne obmedzite

118
00:09:15,720 –> 00:09:20,080
porcie ktore zvierata jedia, tak ziju dlhsie.

119
00:09:20,080 –> 00:09:22,840
Ovela, ovela dlhsie.

120
00:09:25,880 –> 00:09:30,640
Takze dalsia samozrejma otazka je
– Ak spravite to iste s ludmi,

121
00:09:30,640 –> 00:09:33,680
bude to mat rovnake ucinky?

122
00:09:35,640 –> 00:09:39,920
No, je to uz osem desatroci
od tohoto pozorovania,

123
00:09:39,920 –> 00:09:43,320
a az teraz vedci
zacinaju skutocne rozumiet

124
00:09:43,320 –> 00:09:47,360
linke medzi kalorickym
obmedzovanim a dlhovekostou u ludi.

125
00:09:47,360 –> 00:09:51,880
Az teraz, sa zda, zaciname
dostavat odpovede.

126
00:10:00,920 –> 00:10:06,000
Washington University je
srdcom tohto noveho vyskumu.

127
00:10:06,000 –> 00:10:09,080
Toto je miesto kde sa prepisuje ludska fyziologia!

128
00:10:09,080 –> 00:10:11,040
Je to uzasne, viete, to ze

129
00:10:11,040 –> 00:10:14,920
jednoducha zmena diety
moze zmenit v podstate

130
00:10:14,920 –> 00:10:17,840
uplne fungovanie celeho ludskeho tela.

131
00:10:19,720 –> 00:10:24,120
“Profesor Luigi Fontana stravil
poslednych desat rokov, studiom skupiny ludi

132
00:10:24,120 –> 00:10:28,520
ktori zavazne obmedzili svoj
denny kaloricky prijem.

133
00:10:30,280 –> 00:10:33,400
“A je neuveritelne prekvapeny
tym, co zistil. ”

134
00:10:34,920 –> 00:10:37,800
Tito ludia su,
ako uplne odlisny druh.

135
00:10:37,800 –> 00:10:40,240
To je dost velke
prehlasenie, nemyslite? Ano!

136
00:10:40,240 –> 00:10:45,040
Zistujeme, ze sa budu
dozivat dlhsie nez ich rodicia a bratia

137
00:10:45,040 –> 00:10:48,080
ktory su na typickej Americkej
strave, alebo typickej zapadnej diete.

138
00:10:53,440 –> 00:10:56,040
“Luigi je jednoznacne ohureny,

139
00:10:56,040 –> 00:11:00,920
“Tak som sa chcel sam stretnut s jednym z tych
ludi co oznacil ako uplne iny ludsky druh.”

140
00:11:00,920 –> 00:11:04,800
Krasny, naozaj krasny dom. Trafili
ste ku mne dobre? V pohode, dobre instrukcie, dakujem.

141
00:11:04,800 –> 00:11:07,280
Joe Cordell je ‘CRonie’ –

142
00:11:07,280 –> 00:11:10,640
to znamena ze sa kaloricky obmedzuje
a prijima len optimalnu vyzivu.

143
00:11:10,640 –> 00:11:14,240
To znamena, ze vela ovocia a zeleniny.

144
00:11:16,280 –> 00:11:18,800
Ja nez ste prisli som viac menej
vsetko vylozil

145
00:11:18,800 –> 00:11:22,920
Myslel som si, ze mozno budete chciet nejake
ranajky. To by bolo vynikajuce, dakujem.

146
00:11:22,920 –> 00:11:25,120
Ked si predstavujem obmedzenie kalorii,

147
00:11:25,120 –> 00:11:30,120
predstavujem si niekoho, kto zije v podstate na
par mrkvach, alebo nieco take.

148
00:11:30,120 –> 00:11:34,160
Nemyslel som si, ze si
naozaj date ranajky.

149
00:11:34,160 –> 00:11:37,720
“Joe zacina svoj den
s horou ovocia,

150
00:11:37,720 –> 00:11:40,360
“niektore casti vsak vyhadzuje.”

151
00:11:41,360 –> 00:11:45,840
Potom chcem pridat nejake jablko,
do toho, ale ked ste v mojej pozicii,

152
00:11:45,840 –> 00:11:50,840
chcete dostat co najviac nutricnej
hodnoty na celkove mnozstvo kalorii,

153
00:11:50,840 –> 00:11:53,480
a prakticky vsetka
nutricna hodnota je v supke jablka.

154
00:11:53,480 –> 00:11:56,960
Takze si nastruhate viac menej len supky
a zbytok zahodite?

155
00:11:56,960 –> 00:11:59,960
Robite presny opak
toho co robi vacsina ludi.

156
00:11:59,960 –> 00:12:04,160
Je to ok, doslova 95%
z nutricnej hodnoty je v supke …

157
00:12:04,160 –> 00:12:07,840
V supke? Ano.
Zvysok je viac menej len cukor a kalorie.

158
00:12:07,840 –> 00:12:11,480
To je viac menej to, co jedavam
kazde rano. Toto cele?

159
00:12:11,480 –> 00:12:13,080
Ano. To je velka misa.

160
00:12:13,080 –> 00:12:17,360
Zamyslate sa niekedy nad tym, ze, “Co ak toto
cele je nezmysel? Co ak to cele robim zle?”

161
00:12:17,360 –> 00:12:22,360
“Robim to 10 az 20 rokov, a
zrazu veda objavi nieco co povie

162
00:12:22,360 –> 00:12:25,200
“Toto cele je nezmysel.”

163
00:12:25,200 –> 00:12:28,840
Poviem vam, moj brat vazi
o 40kg viac ako ja,

164
00:12:28,840 –> 00:12:33,720
je v mojom veku a vzdy
si so mna utahuje,

165
00:12:33,720 –> 00:12:36,640
vravi mi casto, ze ma prezije

166
00:12:36,640 –> 00:12:39,280
a podla jeho nazoru,
trpim uplne zbytocne.

167
00:12:39,280 –> 00:12:41,360
Ale ide o to, ze ja to co robim, robim rad.

168
00:12:41,360 –> 00:12:44,000
Zdravy zivotny styl moze byt zabava.

169
00:12:44,000 –> 00:12:49,080
“Momentalne sa odhaduje
ze na celom svete je asi 100 tisic Cronies ako Joe –

170
00:12:49,080 –> 00:12:53,680
“ludi zijuci na diete
ktora je bohata na ziviny”

171
00:12:53,680 –> 00:12:55,520
– ale s nizkym obsahom kalorii.

172
00:12:55,520 –> 00:12:59,080
“Joe podla mna vyzera fit, ale
nie je nejak vyzorovo posobivo mlady.

173
00:12:59,080 –> 00:13:02,160
Mozno to Luigi trosku prehana.”

174
00:13:02,160 –> 00:13:05,480
Co by som chcel spravit, je zobrat
nas oboch a spravit zopar testov.

175
00:13:05,480 –> 00:13:07,120
Chcem vidiet, ako sa s nim zrovnavam.

176
00:13:07,120 –> 00:13:11,120
OK, som za. Takze, ideme na to?

177
00:13:11,120 –> 00:13:16,040
To je skutocne vyzva,… sutaz
ktoru mam podozrenie, asi prehram!

178
00:13:20,040 –> 00:13:25,360
Za poslednych desat rokov, Joe
jedol maximalne 1900 kalorii denne.

179
00:13:25,360 –> 00:13:28,720
Ja jem priemerne okolo 2300,

180
00:13:28,720 –> 00:13:31,560
vela z toho su vsak sisky a hamburgery.

181
00:13:31,560 –> 00:13:33,880
Kolko si myslite, ze vazite?

182
00:13:33,880 –> 00:13:37,640
Pravdepodobne okolo 82kg. Ooo, viac ako 82kg!

183
00:13:37,640 –> 00:13:39,280
Nadychnite sa!

184
00:13:39,280 –> 00:13:44,000
Mal by som mat okolo 59, 60, 61kg.

185
00:13:44,000 –> 00:13:46,480
Musime to posunut smerom nadol o jeden stupen.

186
00:13:46,480 –> 00:13:49,120
60kg. Presne ste to trafili.

187
00:13:51,240 –> 00:13:55,320
Sme obaja vyse 50tky,
ale naozaj si nemyslim, ze

188
00:13:55,320 –> 00:13:58,680
vyzerame ako odlisna
generacia, nie to este, ako odlisny ludsky druh.

189
00:13:58,680 –> 00:14:01,520
Tak ako sa lisime?

190
00:14:01,520 –> 00:14:05,280
Potrebujem aby ste teraz trosku
relaxovali. Sadnite si, a chvilku pocuvajte.

191
00:14:08,640 –> 00:14:12,880
Niektore z najjednoduchsich sposobov posudenia
starnutia nevyzaduju potrebne specialne vybavenie.

192
00:14:12,880 –> 00:14:14,240
Oh, toto zacina byt dobre.

193
00:14:14,240 –> 00:14:17,040
Balance je udrziavany vnutornym uchom.

194
00:14:21,560 –> 00:14:24,600
“Ako starnete, usne struktury sa zhorsuju

195
00:14:24,600 –> 00:14:27,120
a vas balance sa tak isto zhorsi.”

196
00:14:27,120 –> 00:14:30,920
Este raz. “Mozete sa otestovat
tym, ze budete stat na svojej slabsiej nohe

197
00:14:30,920 –> 00:14:32,720
So zavretymi ocami.”

198
00:14:32,720 –> 00:14:36,360
Ako dlho som urobil? 6.59
sekund. To nie je moc dobre.

199
00:14:36,360 –> 00:14:38,360
“To nie je vobec dobre.

200
00:14:38,360 –> 00:14:41,920
“Priemerny 55-rocny clovek
musi vydrzat aspon 8 sekund. ”

201
00:14:41,920 –> 00:14:43,760
Si uz na …

202
00:14:43,760 –> 00:14:47,720
Vysledok mas tak dobry
ako priemerny 20 rocny mladik.

203
00:14:47,720 –> 00:14:50,400
Okolo 30 sekund je to, co
maximalne zvladnu 20 rocny,

204
00:14:50,400 –> 00:14:52,960
a to je len jedna z tych zrucnosti
co dramaticky klesaju umerne s vekom.

205
00:14:52,960 –> 00:14:56,680
Myslim, ze ste mi ukazali
pointu. Stop. Mozete prestat, ano.

206
00:14:58,720 –> 00:15:03,040
“Dalsi dobry test je reakcny
cas, ktory tiez klesa s vekom. ”

207
00:15:03,040 –> 00:15:04,840
To nie je moc dobre. Ledva osem centimetrov.

208
00:15:04,840 –> 00:15:07,600
“Na tento test potrebuje len pravitko.

209
00:15:07,600 –> 00:15:11,320
“Vo vasom veku, a dobrom zdravi, by ste mali byt schopni
chytat pravitko okolo 12cm znacky. ”

210
00:15:13,200 –> 00:15:16,680
Velmi dobre. To bolo 11cm. Dari sa
vam velmi dobre, musim uznat.

211
00:15:21,480 –> 00:15:25,120
Luigiho metody su
viac vedecke.

212
00:15:25,120 –> 00:15:28,600
Urobili sme mnozstvo lekarskych testov,

213
00:15:28,600 –> 00:15:30,920
vratane vysetrenia krvi.

214
00:15:30,920 –> 00:15:34,680
Teraz, nam ide ukazat nase vysledky.

215
00:15:34,680 –> 00:15:37,800
Pocit, ako by ste sedeli
pred riaditelnov, ze?

216
00:15:37,800 –> 00:15:39,200
Cakanie na vysledky.

217
00:15:39,200 –> 00:15:43,160
Dostanem jednotku?
Ci dvojku, alebo az trojku?

218
00:15:43,160 –> 00:15:45,080
“Luigiho tvar mi hovori, ze

219
00:15:45,080 –> 00:15:48,480
to, co budem teraz
pocut, nebude dobra sprava. ”

220
00:15:48,480 –> 00:15:53,600
Celkovy telesny tuk u Joa je 11,5%.

221
00:15:53,600 –> 00:15:57,640
To je typicke pre super sportovcov.

222
00:15:57,640 –> 00:16:01,000
11% telesneho tuku je velmi nizke

223
00:16:01,000 –> 00:16:04,720
pre 54 az
55-rocneho muza.

224
00:16:04,720 –> 00:16:07,360
Vas tuk je presne 27,1%.

225
00:16:07,360 –> 00:16:09,240
Vyse tretina vasho tela je tuk.

226
00:16:09,240 –> 00:16:13,280
Dakujem … ze ste
to tak zdoraznili!

227
00:16:13,280 –> 00:16:17,640
“A este stale neskoncil
o mojom tuku. ”

228
00:16:17,640 –> 00:16:19,720
Brusny tuk je okolo 30%.

229
00:16:19,720 –> 00:16:23,760
Brusny tuk je naozaj zly.

230
00:16:23,760 –> 00:16:26,480
Cim vyssia hladina brusneho
tuku, tym vyssie je riziko

231
00:16:26,480 –> 00:16:29,560
rozvoja cukrovky 2. typu,
a kardiovaskularnych ochoreni.

232
00:16:29,560 –> 00:16:32,680
Nie je pochyb, ze to je tiez
rizikovy faktor pre rakovinu.

233
00:16:33,880 –> 00:16:37,920
Takze, v podstate, vas
kardio-metabolicky profil,

234
00:16:37,920 –> 00:16:39,920
nie je dobry. Na vas vek.

235
00:16:39,920 –> 00:16:42,400
Myslim, ze by ste mali nieco urobit,
nieco co najskor zmenit.

236
00:16:42,400 –> 00:16:44,800
Co mozem povedat tu, je, ze Joseph

237
00:16:44,800 –> 00:16:48,280
nebude trpiet na ziadne
kardiovaskularne ochorenie.

238
00:16:48,280 –> 00:16:50,480
Pre neho je uplne nemozne aby mal mozgovu prihodu,

239
00:16:50,480 –> 00:16:53,080
infarkt myokardu alebo srdcove zlyhanie.

240
00:16:53,080 –> 00:16:56,080
A zrovna tieto tri choroby su zodpovedne

241
00:16:56,080 –> 00:16:58,960
za 40% vsetkych umrti v USA a Velkej Britanii.

242
00:16:58,960 –> 00:17:02,280
Ziadna sanca, ze zomrie na cosi take?
Myslim, ze ma sancu tak jednu z miliona.

243
00:17:02,280 –> 00:17:06,040
A keby som presiel na jeho
zivotny styl…?

244
00:17:06,040 –> 00:17:08,560
Do roka, budete vylieceny.

245
00:17:12,360 –> 00:17:16,040
Az teraz som pochopil, o com Luigi hovoril.

246
00:17:16,040 –> 00:17:20,600
Je to, ako by sme boli
dva rozne ludske druhy.

247
00:17:20,600 –> 00:17:24,600
Joeova strava udrzuje
jeho organy v perfektnom stave.

248
00:17:24,600 –> 00:17:28,080
Zatial co moja dieta ohrozuje
moje zdravie, a to velmi rapidne.

249
00:17:30,480 –> 00:17:34,840
No, toto bolo velmi alarmujuce.
Luigi sa tiez moc nevyberal slovami.

250
00:17:34,840 –> 00:17:36,920
Hovoril o brusnom tuku.

251
00:17:36,920 –> 00:17:39,440
V skutocnosti, hovoril
hodne zrovna o mojom brusneho tuku.

252
00:17:39,440 –> 00:17:42,160
Nikdy som o sebe
neuvazoval ako o niekom viac menej zlozenom z tuku.

253
00:17:42,160 –> 00:17:45,120
Ale to boli vlastne
dve vizie ktore mi boli ukazane.

254
00:17:45,120 –> 00:17:48,240
Na jednej strane, smer ktorym budem pokracovat
ak nic nezmenim…

255
00:17:48,240 –> 00:17:53,000
Smerujem celkom zaiste
smerom k srdcovej chorobe, alebo niecomu este horsiemu.

256
00:17:53,000 –> 00:17:57,720
Na druhej strane je, co ak by som
vyskusal kaloricke obmedzovanie – post?

257
00:17:57,720 –> 00:18:01,960
Povedal, ze by som mohol byt
uplne vylieceny do roka.

258
00:18:01,960 –> 00:18:06,160
Moje rizikove faktory by sa mohli zmenit
z tych co ma spravia

259
00:18:06,160 –> 00:18:08,520
asi obetou srdcoveho infarktu,

260
00:18:08,520 –> 00:18:10,360
na sancu takeho niecoho – jedna k milionu.

261
00:18:10,360 –> 00:18:15,400
Ked si to poviete takto z ostra,
clovek zacne o tom hodne premyslat.

262
00:18:31,160 –> 00:18:35,920
Aj ked dokazy podporujuce
vyhody kalorickej restrikcie

263
00:18:35,920 –> 00:18:38,800
su silnejsie kazdym dnom,

264
00:18:38,800 –> 00:18:42,640
nemozem si vo vsetkej uprimnosti predstavit
ze by som robil nieco take, ako to co robi Joe.

265
00:18:45,080 –> 00:18:48,080
Co vo mne vytvara vcelku velku dilemu.

266
00:18:50,080 –> 00:18:53,480
Co naozaj chcem spravit, je sa pokusit

267
00:18:53,480 –> 00:18:57,880
pochopit sposob
akym kaloricke obmedzenie funguje,

268
00:18:57,880 –> 00:19:01,240
potom nejak z toho dostat
vsetky vyhody

269
00:19:01,240 –> 00:19:03,960
a cele to spravit tak, aby som vlastne moc nemusel robit.

270
00:19:03,960 –> 00:19:05,560
Som v Los Angeles,

271
00:19:05,560 –> 00:19:09,400
v meste co je zname svojou
honbou za mladostou.

272
00:19:09,400 –> 00:19:12,280
V skutocnosti, mnoho ludi si tu mysli,

273
00:19:12,280 –> 00:19:15,520
ze starnutie a
vrasky su niecim volitelnym.

274
00:19:15,520 –> 00:19:19,360
Nejdem ale vyhladat nieco tak
povrchneho ako je plasticky chirurg.

275
00:19:19,360 –> 00:19:23,280
Som tu aby som sa stretol s jednym z
najvacsich odbornikov na starnutie.

276
00:19:31,640 –> 00:19:34,280
Dobry den. Dobry den.

277
00:19:34,280 –> 00:19:39,400
Profesor Valter Longo studuje
zlozite mechanizmy, ktore kontroluju starnutie.

278
00:19:41,600 –> 00:19:47,120
Vedie vyskum o kritickych cestach
co linkuju ako a co jeme, s tym ako starneme.

279
00:19:49,400 –> 00:19:52,360
Berie ma, aby som sa pozrel na dve specielne mysi.

280
00:19:52,360 –> 00:19:58,160
Obe su rovnakeho
veku, rovnakeho druhu a rovnakeho pohlavia.

281
00:19:58,160 –> 00:20:02,040
Ale je medzi nimi jeden
vyznamny rozdiel.

282
00:20:02,040 –> 00:20:06,040
Ta mala myska bude
zit ovela ovela dlhsie

283
00:20:06,040 –> 00:20:08,120
nez ta velka.

284
00:20:11,320 –> 00:20:13,560
Tato myska tu

285
00:20:13,560 –> 00:20:17,720
drzi svetovy rekord v
predlzeni veku u cicavcov.

286
00:20:17,720 –> 00:20:19,920
Oh, naozaj. To je pozoruhodne.

287
00:20:19,920 –> 00:20:22,840
Tak, ako dlho tento
poddruh mysky vydrzi?

288
00:20:22,840 –> 00:20:25,560
Tato velka mys sa dozije asi dva roky,

289
00:20:25,560 –> 00:20:28,480
a tato mala myska tu,
sa dozije asi o 40% dlhsie.

290
00:20:28,480 –> 00:20:30,880
Vazne. Su tak velmi
odlisne?

291
00:20:30,880 –> 00:20:33,120
Whoa! Snazi sa ma uhryznut.

292
00:20:33,120 –> 00:20:35,600
(Smiech)

293
00:20:35,600 –> 00:20:40,120
Citil som, ako presiel zub cez rukavicu.
Mali by sme si dat dvojite rukavice.

294
00:20:40,120 –> 00:20:43,360
Ano, naucil som sa to na vlastnej kozi!

295
00:20:43,360 –> 00:20:46,400
Ta velka mys ma uz
teraz 50% pravdepodobnost, ze onedhlo bude mrtva.

296
00:20:46,400 –> 00:20:48,560
OK, takze sa jej dari vcelku dobre, ak je este stale nazive?

297
00:20:48,560 –> 00:20:51,000
Ma stastie, ze je nazive, to je pravda.

298
00:20:51,000 –> 00:20:54,680
Ta mala ma pred sebou naopak este najmenej
dalsi rok zivota. O, dobre.

299
00:20:54,680 –> 00:20:57,640
Ta mala myska bude zit asi
ekvivalent toho, co by bolo 120 rokov u cloveka?

300
00:20:57,640 –> 00:21:02,680
Presne tak, v prepocte akoby dalsich 30
az do 40 rokov, v ludskych rokoch.

301
00:21:02,680 –> 00:21:06,920
Mozem si ju zdvihnut? Jasne
, za chvost. OK.

302
00:21:10,040 –> 00:21:11,680
Mala myska co drzim

303
00:21:11,680 –> 00:21:15,160
je vlastne umely vytvor.

304
00:21:15,160 –> 00:21:18,520
Dovod, preco je taka
mala a tak dlho zije

305
00:21:18,520 –> 00:21:21,720
je v tom, ze je
geneticky modifikovana.

306
00:21:21,720 –> 00:21:26,000
Ma neuveritelne nizku
hladinu rastoveho hormonu

307
00:21:26,000 –> 00:21:29,080
takzvaneho inzulin rastoveho faktoru 1, alebo IGF-1.

308
00:21:29,080 –> 00:21:32,240
A zda sa, ze IGF-1 je klucovym faktorom

309
00:21:32,240 –> 00:21:35,760
spajajucim obmedzenie kalorii
s dlhovekostou.

310
00:21:42,080 –> 00:21:46,240
Naznaky toho preco tomu tak je, sme zistili
pozorovanim skupiny ludi

311
00:21:46,240 –> 00:21:48,880
zijucich v odlahlej oblasti Ekvadoru.

312
00:21:50,720 –> 00:21:54,760
Maju velmi zriedkavy
stav, tzv. Laronov syndrom,

313
00:21:54,760 –> 00:21:58,960
ktory postihuje menej ako
350 ludi na celom svete.

314
00:22:03,360 –> 00:22:05,960
To ste vy, ze ano? Na tej fotke
vyzerate ako obor, ze?

315
00:22:05,960 –> 00:22:08,600
Medzi nimi som vzdy ten najvyssi.

316
00:22:08,600 –> 00:22:13,120
Najmensi z nich je len nieco malo cez
meter vysoky.

317
00:22:13,120 –> 00:22:15,160
Tak to je zhruba vo vyske pupku.
Je to pravda? Ano.

318
00:22:15,160 –> 00:22:20,840
“Co zaujma vedcov
ako Valter vsak nie je ich velkost,

319
00:22:20,840 –> 00:22:25,960
, ale skutocnost, ze sa zdaju byt prakticky
imunny na dvoch z najvacsich zabijakov zapadnej spolocnosti.”

320
00:22:25,960 –> 00:22:27,680
Velkym objavom pre nas bolo, ,

321
00:22:27,680 –> 00:22:31,160
ze, tato skupina netrpi
ci uz cukrovkou alebo rakovinu.

322
00:22:31,160 –> 00:22:33,720
Robia vsetko normalne,
presne tak ako to robi vela z nas,

323
00:22:33,720 –> 00:22:37,160
piju, fajcia, a tak?
Ano, robia vsetko normalne, a aj viac,

324
00:22:37,160 –> 00:22:39,760
a vedu vela krat velmi nezdravy zivotny styl.

325
00:22:39,760 –> 00:22:43,720
Vacsina z nich trpi v urcitom rozsahu
nadvahou.

326
00:22:43,720 –> 00:22:46,520
Zda sa, ze naozaj sa nedivaju
a nesleduju to co robia.

327
00:22:46,520 –> 00:22:49,640
Fajcia a jedia velmi
vysoko kaloricku stravu,

328
00:22:49,640 –> 00:22:53,440
a potom sa na mna pozru a povedia,

329
00:22:53,440 –> 00:22:55,080
“Ale co, to nevadi. Ved som imunny.”

330
00:22:55,080 –> 00:22:59,480
Co je neuveritelne
je, ze neexistuje ziadna evidencia

331
00:22:59,480 –> 00:23:02,920
ze by co len jeden z nich
niekedy umrel na rakovinu,

332
00:23:02,920 –> 00:23:06,640
zatial co vsak ich normalny vysoky pribuzny
dostanu rakovinu ako vacsina z nas.

333
00:23:08,000 –> 00:23:13,000
Ludia s Laronovym syndromom maju
geneticku mutaciu, ktora ich robi malymi,

334
00:23:13,000 –> 00:23:17,280
ale ktora ich ochranuje
proti skoro vsetkym ochoreniam.

335
00:23:19,320 –> 00:23:21,440
Je to neuveritelne, pracovat s nimi.

336
00:23:23,640 –> 00:23:29,120
Je to dobra skupina, a samozrejme pre
nas je to skupina, ktora nam vdaka jednej mutacii,

337
00:23:29,120 –> 00:23:33,480
moze povedat hodne o cukrovke, rakovine,
kardiovaskularnych ochorenia a starnuti.

338
00:23:37,240 –> 00:23:40,440
Ekvadorsky dedincania
a dlho zijuce mysi

339
00:23:40,440 –> 00:23:42,720
maju nieco spolocne.

340
00:23:42,720 –> 00:23:46,240
Ich telo produkuje
vynimocne nizke urovne

341
00:23:46,240 –> 00:23:48,080
rastoveho hormonu IGF-1.

342
00:23:50,520 –> 00:23:56,440
Tento objav pomohol Valterovi dat si
dokopy suvis uloh, ake ma IGF-1

343
00:23:56,440 –> 00:23:59,400
v zlozitom procese starnutia.

344
00:23:59,400 –> 00:24:02,800
Nase tela su
zvycajne v rezime rychlo-rychlo –

345
00:24:02,800 –> 00:24:07,560
bunky su neustale pohanane
IGF-1 aby sa delili.

346
00:24:07,560 –> 00:24:10,400
Ale ked hladina IGF-1 poklesne,

347
00:24:10,400 –> 00:24:14,080
nase bunky sa presunu do
uplne odlisneho rezimu.

348
00:24:14,080 –> 00:24:17,480
Telo zacne spomalovat tvorbu novych buniek

349
00:24:17,480 –> 00:24:20,800
a zacne opravovat
existujuce bunky.

350
00:24:20,800 –> 00:24:25,520
Poskodena DNA sa zacne opravovat.

351
00:24:25,520 –> 00:24:29,480
A to je to, preco su mysi a tiez
dedincania takto chraneny

352
00:24:29,480 –> 00:24:31,600
od veku pribuznych chorob.

353
00:24:40,480 –> 00:24:44,160
Ale ake je tu suvislost s
kalorikym obmedzovanim u ludi?

354
00:24:44,160 –> 00:24:49,960
Valter postavil velmi
jednoduchu, velmi Californsku analogiu.

355
00:24:51,440 –> 00:24:55,040
Ukazuje sa, ze je
nieco v potravinach, ktore jeme

356
00:24:55,040 –> 00:24:59,280
nieco co ovplyvnuje, ako vela
IGF-1 nase telo bude produkovat.

357
00:24:59,280 –> 00:25:01,880
Tym niecim su bielkoviny: Protein.

358
00:25:02,920 –> 00:25:07,800
Ked jeme vela bielkovin, nase
bunky doslova zostavaju zamknute v rychlo-rychlo rezime.

359
00:25:07,800 –> 00:25:10,920
Takze je to v podstate ako keby
ste dali nohu na plyn,

360
00:25:10,920 –> 00:25:13,320
a prikazal: “Ideme! Ideme! Rychlo!”
Je to tak? Presne tak.

361
00:25:13,320 –> 00:25:17,000
Je to nieco co tlaci bunku aby spalovala co najviac paliva.

362
00:25:17,000 –> 00:25:19,000
V rychlo-rychlo rezime,

363
00:25:19,000 –> 00:25:22,800
je telo nachylnejsie
na niektore druhy rakoviny a cukrovky,

364
00:25:22,800 –> 00:25:25,120
viac menej preto, ze vase bunky rastu prilis rychlo

365
00:25:25,120 –> 00:25:27,440
na to aby ich telo dokazalo efektivne opravovat.

366
00:25:27,440 –> 00:25:30,760
Takze je to ako neustala
jazda autom

367
00:25:30,760 –> 00:25:32,560
bez toho aby ste ho niekedy vzali k mechanikovi.

368
00:25:32,560 –> 00:25:36,160
Dobre, takze to bude to,
v podstate, nejako najst sposob, ako

369
00:25:36,160 –> 00:25:39,120
prepnut telo
z neustaleho “Brm, brm, brm,”

370
00:25:39,120 –> 00:25:44,080
do opravneho rezimu, “Vypni na chvilu
, skus mi opravit moju DNA.” Presne tak!

371
00:25:46,480 –> 00:25:49,400
Takze, ako mam ale znizit hladinu mojho IGF-1?

372
00:25:50,520 –> 00:25:54,560
No, studie o kalorickom obmedzovani
navrhuju, ze jest menej velmi pomaha,

373
00:25:54,560 –> 00:25:55,960
ale samo o sebe to nestaci.

374
00:25:57,040 –> 00:26:01,280
Nie len obmedzenie kalorii, ale
musi sa tiez vyznamne obmedzit prijem bielkovin.

375
00:26:01,280 –> 00:26:05,640
Nie uplne
– to by bol velmi zly napad.

376
00:26:05,640 –> 00:26:08,520
Je to o tom udrzat sa
v urcitych medziach,

377
00:26:08,520 –> 00:26:11,800
nieco, co vacsina z nas nerobi.

378
00:26:11,800 –> 00:26:15,840
A naozaj nemusite byt
CRonie na to aby ste znizili IGF-1!

379
00:26:15,840 –> 00:26:18,840
Existuje iny sposob,a to:
Post.

380
00:26:18,840 –> 00:26:25,560
Pocas postu, nastava daleko
dramatickejsia a ovela rychlejsia odozva,

381
00:26:25,560 –> 00:26:30,880
a to uz po 24 hodinach nejedenia,
sa znizi hladina glukozy

382
00:26:30,880 –> 00:26:35,480
a potom sa ako odozva tiez znizi hladina
rastoveho faktoru, ktorym je IGF-1.

383
00:26:38,360 –> 00:26:42,960
Pre mna je velmi tazko uverit,
ze len par dni postu

384
00:26:42,960 –> 00:26:47,480
by malo nakopnut moje
telo do uplne ineho, zdraveho stavu.

385
00:26:49,200 –> 00:26:53,720
Ale rozhodne ma to zaujalo,
a tak sa chcem dozvediet viac.

386
00:26:53,720 –> 00:26:56,360
Tak som si dal zmerat svoj IGF
v Londyne,

387
00:26:56,360 –> 00:26:59,200
a povedali mi, ze je to presne 28.

388
00:26:59,200 –> 00:27:01,200
Je to dobre? Ci zle?

389
00:27:01,200 –> 00:27:05,160
No nie je to zle,
ale je to stale dost vysoke…

390
00:27:05,160 –> 00:27:09,160
Na zaklade viacerych
studii, vratane tej nasej,

391
00:27:09,160 –> 00:27:14,480
vas toto cislo posuva do vyssej kategorie rizika
pre niekolko roznych druhov rakoviny,

392
00:27:14,480 –> 00:27:16,840
vratane rakoviny prostaty.

393
00:27:16,840 –> 00:27:21,320
Valter sa domnieva, by som mal vidiet
pomerne posobive vysledky

394
00:27:21,320 –> 00:27:25,400
uz po zhruba troch dnoch a
styroch nociach postu.

395
00:27:25,400 –> 00:27:27,680
Ale je to sklucujuca vyhliadka.

396
00:27:29,040 –> 00:27:32,080
Myslim, ze drzat post je tazke,
ze? Uz ste to niekedy robili?

397
00:27:32,080 –> 00:27:34,280
Ano, skusil som to,

398
00:27:34,280 –> 00:27:38,280
postil som sa po styri dni uz niekolkokrat

399
00:27:38,280 –> 00:27:39,920
a pre mna sameho to bolo dost tazke, ano.

400
00:27:39,920 –> 00:27:43,360
Ale robim to stale,… avsak ked sa pozeram
dopredu na prichadzajuci post,

401
00:27:43,360 –> 00:27:46,800
stale to vidim ako styri
dni, na ktore sa moc netesim.

402
00:27:46,800 –> 00:27:48,920
Niektori ludia sa na to tesia, ale ja nie.

403
00:27:48,920 –> 00:27:52,600
Som Talian, takze sa tesim
na to kedy sa zase dobre najem, to viete.

404
00:27:52,600 –> 00:27:55,200
Budem si vas obraz drzat v mysli…

405
00:27:55,200 –> 00:27:58,240
Ako sa nenasytny talian zdrzal jedenia.
Pripomeniem si to ked sa budem citit slaby.

406
00:27:58,240 –> 00:27:59,440
To je ono. Dakujem.

407
00:28:08,520 –> 00:28:11,480
Dlhsi post moze byt nebezpecny

408
00:28:11,480 –> 00:28:15,080
a Valter si mysli, ze by to mali
robit len ludia v dobrom zdravotnom stave

409
00:28:15,080 –> 00:28:18,240
a pokial mozno, pod starostlivym dohladom.

410
00:28:18,240 –> 00:28:20,120
Takze sme sa dohodli, ze bude na mna dohliadat.

411
00:28:21,760 –> 00:28:26,360
OK, rozhodol som sa, ze
idem ten post teda vyskusat,

412
00:28:26,360 –> 00:28:29,280
a bude to
presne tri a pol dnovy post

413
00:28:29,280 –> 00:28:35,120
a jedine co mozem mat je
vela vody a cierny caj

414
00:28:35,120 –> 00:28:39,520
a jednu 50-kaloriovu
polievku za den.

415
00:28:39,520 –> 00:28:44,680
A ide sa na to … O Boze, nikdy som nic
podobne este nespravil,

416
00:28:44,680 –> 00:28:46,920
tak si predstavujem, ze to bude
pre mna naozaj tazke.

417
00:28:46,920 –> 00:28:49,000
Ale som na to zvedavy.

418
00:28:49,000 –> 00:28:52,640
Tiez, musim priznat, ze
som docela znepokojeny niektorymi

419
00:28:52,640 –> 00:28:55,880
zlymi spravami o mojom zdravi
, spravy ktore som v poslednom case dost dostaval,

420
00:28:55,880 –> 00:29:01,960
takze, hm … je to pre mna vyzva,
ale som si isty, ze to nejak zvladnem.

421
00:29:03,360 –> 00:29:05,720
Viac menej isty,.

422
00:29:08,520 –> 00:29:10,920
A tak, moj post zacina!

423
00:29:17,480 –> 00:29:22,600
No. Teraz je presne 22:30
v noci a mam hlad.

424
00:29:22,600 –> 00:29:29,120
Je to dokopy asi len 25
hodin, co som naposledy nieco jedol

425
00:29:29,120 –> 00:29:35,360
a perspektiva toho ze pojdem do postele
zatial co som hladny mi nerobi vobec dobre.

426
00:29:36,960 –> 00:29:39,680
Myslim ze ma to dostava,
pretoze minulu noc som mal sen

427
00:29:39,680 –> 00:29:44,080
o tom ako som zjedol sendvic a
potom som sa citil hrozne previnilo.

428
00:29:44,080 –> 00:29:47,960
Bol to tak zivy sen, ze som sa po zobudeni obzeral
ci niesu nejake omrvinky na posteli,… ale bohuzial neboli.

429
00:29:47,960 –> 00:29:50,440
Myslim, ze je cas ist do prace.

430
00:29:53,480 –> 00:29:56,240
Jednoduche dietne opatrenia

431
00:29:56,240 –> 00:29:59,120
mozu naozaj zmenit ako
funguje ludske telo.

432
00:29:59,120 –> 00:30:01,600
Toto vas dava do vyssej rizikovej kategorie.

433
00:30:04,440 –> 00:30:08,920
Tak ako ma Valter varoval,
Prvy den bol naozaj tazky.

434
00:30:08,920 –> 00:30:11,520
Nie tak celkom, preto ze som mal hlad,

435
00:30:11,520 –> 00:30:15,880
ale jednoducho preto, ze som este nikdy
nic take predtym nerobil.

436
00:30:15,880 –> 00:30:18,880
Bol to strach z neznameho.

437
00:30:18,880 –> 00:30:22,720
Po zotmeni, zacinam mat dojem
ze to cele bol jeden velmi zly napad …

438
00:30:25,400 –> 00:30:28,280
.. zvlast, po tom, ako som
mal veceru s nasim filmovym stabom.

439
00:30:33,600 –> 00:30:36,120
Alebo lepsie povedane, po tom co oni mali veceru.

440
00:30:38,160 –> 00:30:41,720
Takze, ano, som v
krasnej starej korejskej restauracii

441
00:30:41,720 –> 00:30:45,200
s celou nasou posadkou.

442
00:30:45,200 –> 00:30:48,240
A ako vidite, v sucasnej dobe sa pekne napchavaju..

443
00:30:48,240 –> 00:30:50,440
Chuti vam, chlapci?

444
00:30:50,440 –> 00:30:51,680
Je to vyborne. Ano.

445
00:30:51,680 –> 00:30:56,560
Naozaj to dobre vonia. Naozaj,
ale naozaj by mi nevadilo trosku si zahryznut.

446
00:30:59,480 –> 00:31:02,080
Citim velky hlad.

447
00:31:03,760 –> 00:31:08,720
Nastastie, moja vecera uz
na mna caka v hotelovej izbe.

448
00:31:13,080 –> 00:31:15,880
Musel som odist, nemohol som
sa na to uz dlhsie divat.

449
00:31:22,360 –> 00:31:26,440
(Vzdych) Moja vynikajuca miso polievka je tu.

450
00:31:26,440 –> 00:31:29,280
Trosku si ju zamiesam hotelovym perom,

451
00:31:29,280 –> 00:31:31,680
pretoze som tu nenasiel ziadny pribor.

452
00:31:33,240 –> 00:31:34,960
Hmmmm!

453
00:31:36,280 –> 00:31:38,960
Zdravie. Celych jeho 25 kalorii.

454
00:31:38,960 –> 00:31:40,960
A jak sa na to tesim.

455
00:31:44,400 –> 00:31:46,440
Oh!

456
00:31:48,160 –> 00:31:52,160
OK, v konecne nejaka zmena v celom dni postu.

457
00:31:52,160 –> 00:31:54,440
Chutne ranajky, cierny caj.

458
00:31:54,440 –> 00:31:58,200
Citim sa trochu na omdletie
ale inak som vlastne v poriadku.

459
00:31:58,200 –> 00:32:00,160
Takze, uz je len 24 hodin predomnou

460
00:32:00,160 –> 00:32:03,440
a teraz uz som si isty
za to nejak dokazem vydrzat.

461
00:32:11,760 –> 00:32:15,120
Zistil som jednu vec, ze hlad
nenarasta umerne casu,

462
00:32:15,120 –> 00:32:16,880
ale prichadza vo vlnach, ktore vzdy prejdu.

463
00:32:18,200 –> 00:32:21,760
V tomto bode, uz moje telo vycerpalo
vsetky zasoby glukozy

464
00:32:21,760 –> 00:32:26,200
a presiel som na
spalovanie tukov ako hlavneho zdroja energie.

465
00:32:26,200 –> 00:32:27,960
A ak ma Valter pravdu,

466
00:32:27,960 –> 00:32:33,000
moja pecen by mala tiez
uz prestat vyrabat tolko IGF-1,

467
00:32:33,000 –> 00:32:36,040
a zaviest moje bunky do opravneho rezimu.

468
00:32:39,680 –> 00:32:44,600
Konecne, je 7 hodin rano, stvrty den,
Idem si dat spravit krvny test.

469
00:32:45,600 –> 00:32:49,440
Takze, po tomto, sa mozem ist
naranajkovat? Absolutne!

470
00:32:49,440 –> 00:32:51,560
Prve jedlo po
troch a pol dnoch,

471
00:32:51,560 –> 00:32:55,760
prve jedlo za 86 hodin.
No, kto by to pocital (?)

472
00:32:55,760 –> 00:32:58,640
Ja len dufam, ze
sa ukazu nejake zmeny,

473
00:32:58,640 –> 00:33:02,120
hlavne co sa tyka mojho IGF, pretoze
ak som stravil tri a pol dna

474
00:33:02,120 –> 00:33:05,440
az skoro styri dni nejedenim a
vysledky by boli uplne nulove,

475
00:33:05,440 –> 00:33:07,760
to by bolo pre mna velmi depresivne.

476
00:33:09,800 –> 00:33:13,360
Post sa skoncil.

477
00:33:13,360 –> 00:33:16,720
Mmm. Ah! To je velmi …

478
00:33:16,720 –> 00:33:19,400
Uplne citim ako sa mi zacinaju
vyplnat vsetky prazdne miesta.

479
00:33:19,400 –> 00:33:23,360
Vlasne som ani nebol az tak hrozne hladny
ked som sa dnes rano prebudil, ale …

480
00:33:25,840 –> 00:33:28,960
.. ked som zacal jest, az potom som
si uvedomit, co to bolo, co mi tak chybalo.

481
00:33:33,280 –> 00:33:37,800
Neskor popoludni, sa stretnem
s Valterom aby som zistil

482
00:33:37,800 –> 00:33:39,600
ci toto vsetko bolo na nieco dobre.

483
00:33:41,120 –> 00:33:44,960
Dnes rano som skoncil post, a
mal som zemiakovu kasu a slaninku

484
00:33:44,960 –> 00:33:47,600
a citim sa lepsie. Oh, velmi dobre.

485
00:33:47,600 –> 00:33:50,960
A budem sa citit este lepsie
ak sa ukaze, ze mam dobre vysledky.

486
00:33:50,960 –> 00:33:53,640
Ano, tak podme sa na ne pozriet.

487
00:33:53,640 –> 00:33:58,240
Takze, vas inzulin rastovy factor
jedna, cize IGF-1,… toto je bezna hodnota.

488
00:33:58,240 –> 00:34:01,640
Wow. Zlou spravou je, ze ste takmer
v hornej casti normalneho rozmedzia.

489
00:34:01,640 –> 00:34:03,760
Ale na americke normy,
ste na tom vcelku dobre.

490
00:34:03,760 –> 00:34:07,440
Nie najlepsie, ale tiez nie
uplne zle. Som ako priemerny American, ze?

491
00:34:07,440 –> 00:34:10,520
To je pravda, ano.
Ale dobra sprava je,

492
00:34:10,520 –> 00:34:13,880
ze vdaka hladovke, ste spadli
na takmer polovicnu hodnotu. Wow.

493
00:34:13,880 –> 00:34:16,480
To je vela, nie?
Ano. To je velky pokles.

494
00:34:16,480 –> 00:34:18,960
Je to velmi dramaticky pokles,
cize na hladovku reagujete velmi dobre.

495
00:34:18,960 –> 00:34:20,960
Musim povedat, toto bolo fascinujuce.

496
00:34:20,960 –> 00:34:25,400
Zazit to bolo velmi,
velmi … no, prekvapujuce.

497
00:34:25,400 –> 00:34:28,320
“Prekvapujuci vysledok
– A obrovska ulava.

498
00:34:28,320 –> 00:34:32,360
“Znizenie mojho IGF-1 by malo znizit
moje riziko niektorych druhov rakoviny,

499
00:34:32,360 –> 00:34:34,920
“Ako je rakovina prostaty,
ktoru mal aj moj otec.

500
00:34:34,920 –> 00:34:37,880
“Moja hladinu cukru v krvi mi tiez
klesla na zdravu uroven,

501
00:34:37,880 –> 00:34:39,760
, z coho som naozaj moc poteseny.”

502
00:34:40,960 –> 00:34:47,840
Vyzyvam Vas najst absolutne cokolvek co by za styri dni
dosiahlo podobne extremne metabolicke zmeny

503
00:34:47,840 –> 00:34:50,160
ako su tieto, nech to je naozaj cokolvek.

504
00:34:50,160 –> 00:34:52,800
Myslim, ze toto je uz teraz
velmi extremne! Ano.

505
00:34:52,800 –> 00:34:55,800
Ano, ale ak viete o niecom,
inom co mozete urobit,

506
00:34:55,800 –> 00:34:58,280
co vam neublizi
a bude mat vyhody,

507
00:34:58,280 –> 00:35:01,800
co sposobuju taketo
zmeny, rad by som o tom vedel. OK.

508
00:35:05,520 –> 00:35:08,280
Ale Valter hovori, ze ak neprejdem

509
00:35:08,280 –> 00:35:11,480
na nizko bielkovinovu,
viac vegetariansku dietu,

510
00:35:11,480 –> 00:35:14,080
ucinky nevydrzia.

511
00:35:16,040 –> 00:35:18,720
Budem musiet drzat post
aspon raz za kazdych par mesiacov,

512
00:35:18,720 –> 00:35:21,920
aby sa zachovali vyhody.

513
00:35:21,920 –> 00:35:25,560
Mozem skutocne vidiet sam seba nieco taketo robit?

514
00:35:25,560 –> 00:35:27,720
Musite urobit rozhodnutie
vo vasom pripade,

515
00:35:27,720 –> 00:35:29,240
vieco co chcete urobit?

516
00:35:29,240 –> 00:35:32,240
Je vela liekov
co by ste mohli uzivat,

517
00:35:32,240 –> 00:35:34,000
ale je to presne to, co chcete urobit?

518
00:35:34,000 –> 00:35:39,200
A ak tak urobite, za niekolko
rokov, alebo v niekolkych rokoch,

519
00:35:39,200 –> 00:35:43,080
budete
typickym 65-rocnym europanom

520
00:35:43,080 –> 00:35:47,120
co berie 8 roznych liekov
denne, a tak, aj to je vasa moznost.

521
00:35:47,120 –> 00:35:50,200
(MICHAEL sa smeje) A tak to je na Vas.

522
00:35:50,200 –> 00:35:54,320
Dakujem, OK! Tak to je
celkom zaujimava volba!

523
00:36:01,440 –> 00:36:04,360
To je naozaj, ale naozaj impozantne,

524
00:36:04,360 –> 00:36:06,400
ze len za
tri a pol dna,

525
00:36:06,400 –> 00:36:09,160
ak su tie vysledky spravne, a
ak su vysledky na zvieratach spravne,

526
00:36:09,160 –> 00:36:12,160
som si takto masivne znizil riziko

527
00:36:12,160 –> 00:36:16,280
celej rady
veku-pribuznych chorob.

528
00:36:16,280 –> 00:36:19,760
Velkou otazkou v mojej
mysli, v tomto okamihu je,

529
00:36:19,760 –> 00:36:22,960
mozem si spravit post raz do mesiac,

530
00:36:22,960 –> 00:36:25,920
dlhodobo, ci permanentne?

531
00:36:25,920 –> 00:36:28,200
Alebo je lepsia
moznost, odlisny sposob,

532
00:36:28,200 –> 00:36:30,200
a viac zvladnutelna cesta,

533
00:36:30,200 –> 00:36:33,640
, ktora moze pre mna spravit viac nez tato,

534
00:36:33,640 –> 00:36:37,360
a pripadne je este trochu viac bezbolestna?

535
00:36:37,360 –> 00:36:40,600
Na co som prisiel
o sebe samom je

536
00:36:40,600 –> 00:36:46,040
ze najvacsim problemom
dlhodobeho hladovania pre mna osobne, som ja sam.

537
00:36:48,480 –> 00:36:51,520
Valter: “Musite
urobit rozhodnutie teraz.

538
00:36:51,520 –> 00:36:52,880
“Hladovanie je tazke.”

539
00:36:55,160 –> 00:36:58,360
Hoci viem uz o vsetkych
uzasnych vyhodach …

540
00:37:00,480 –> 00:37:03,000
.. jednoducho sa nemozem prinutit to robit.

541
00:37:15,680 –> 00:37:18,920
Ale skvela vec na vede je

542
00:37:18,920 –> 00:37:22,720
, ze stale sa najde niekto
kto pracuje na dalsiom vyskume,

543
00:37:22,720 –> 00:37:25,280
v nadvaznosti na to, co dosiahli ini pred nim,

544
00:37:25,280 –> 00:37:28,720
co je dovodom, preco som dnes v Chicagu.

545
00:37:28,720 –> 00:37:33,320
Tu robia studie nie len
na mysiach, ale aj na cloveku.

546
00:37:37,200 –> 00:37:39,920
A zda sa, ze nasli sposob, ako

547
00:37:39,920 –> 00:37:43,520
spravit post trosku viac znesitelnym.

548
00:37:43,520 –> 00:37:48,440
Som tu aby som stretol Dr. Kristu Varadi,

549
00:37:48,440 –> 00:37:52,600
ktora skuma
nieco, co znie trosku jednoduchsie.

550
00:37:52,600 –> 00:37:54,400
Postit sa kazdy druhy den.

551
00:37:54,400 –> 00:37:57,040
Dobry den! Dobry den! Ahojte!

552
00:37:57,040 –> 00:38:00,560
Som rad, ze vas spoznavam.
Podobne! Volam sa Krista Varadi.

553
00:38:00,560 –> 00:38:02,360
Dobry den! Takze co je tou novinkou?

554
00:38:02,360 –> 00:38:04,400
Toto su niektore
komponenty, ktore pouzivame

555
00:38:04,400 –> 00:38:08,040
v diete pocas obden postu.

556
00:38:08,040 –> 00:38:11,560
V zaklade to je zalozene na dni
drastickeho znizenia prijmu kalorii.

557
00:38:11,560 –> 00:38:13,720
U zien, asi 400
az 500 kalorii,

558
00:38:13,720 –> 00:38:16,280
a u muzov, asi okolo 500
az 600 kalorii denne,

559
00:38:16,280 –> 00:38:18,760
a to len v jednom jedle
vzdy okolo obeda.

560
00:38:18,760 –> 00:38:22,040
Tomuto dnu hovorime, ze to je: postny den.

561
00:38:22,040 –> 00:38:24,560
Takze postny den nie je
o uplnej abstinencii.

562
00:38:24,560 –> 00:38:27,640
Je to o jedle, ktore vyzera asi takto.

563
00:38:27,640 –> 00:38:31,480
Co je skvele o kazdom druhom dni postu

564
00:38:31,480 –> 00:38:33,520
je to, co sa deje kazdy druhy den.

565
00:38:33,520 –> 00:38:36,920
A to je den, ktory nazyvame:
dnom neobmedzeneho jedenia,

566
00:38:36,920 –> 00:38:40,560
a to je teda den ked mozete jest cokolvek
chcete. Uplne vsetko co len chcete.

567
00:38:40,560 –> 00:38:44,680
Takze to je zalozene
cele na kazdom druhom dni postu.

568
00:38:44,680 –> 00:38:46,880
Postny den.

569
00:38:46,880 –> 00:38:47,960
Den jedenia.

570
00:38:47,960 –> 00:38:49,880
Postny den.

571
00:38:49,880 –> 00:38:51,320
Den jedenia.

572
00:38:51,320 –> 00:38:56,320
To iste znie jednoduchsie
ako dlhodoby post,

573
00:38:56,320 –> 00:38:59,120
alebo denne obmedzovanie
kalorii, na ktore som sa pozeral predtym.

574
00:38:59,120 –> 00:39:00,680
Ale je to aj tak ucinne?

575
00:39:00,680 –> 00:39:04,800
Momentalne Krista pracuje
na vyskume obeznych pacientov

576
00:39:04,800 –> 00:39:08,280
a vysledky naznacuju, ze tomu tak je.

577
00:39:08,280 –> 00:39:10,840
To, co sme videli, bolo, ze
skupina co drzala post kazdy druhy den

578
00:39:10,840 –> 00:39:12,960
stratila trochu viac vahy,

579
00:39:12,960 –> 00:39:16,360
tak asi o 2 kila viac na osobu
pocas 6-tich mesiacov.

580
00:39:16,360 –> 00:39:21,480
A to bola tiez skupina, kde sme pozorovali
velmi dobry pokles LDL cholesterolu,

581
00:39:21,480 –> 00:39:23,240
ako aj triglyceridov.

582
00:39:23,240 –> 00:39:26,160
LDL cholesterol, je
zly cholesterol,

583
00:39:26,160 –> 00:39:29,440
a triglyceridy
– v podstate ich vyssie mnozstvo,

584
00:39:29,440 –> 00:39:32,720
moze viest k ochoreniu srdca
a ochoreniam spojenym s vekom.

585
00:39:32,720 –> 00:39:36,280
Vidime tiez, naozaj pekne
znizenie krvneho tlaku

586
00:39:36,280 –> 00:39:37,840
pocas dlzky trvania tejto studie.

587
00:39:37,840 –> 00:39:42,040
Takze, vyznamne znizenie
rizikovych faktorov pre ochorenia srdca.

588
00:39:49,400 –> 00:39:51,800
“Navyse k doteraz
skor obmedzenym studiam na ludoch,

589
00:39:51,800 –> 00:39:55,160
je tu vela dobrych
dokazov zo studii na zvieratach

590
00:39:55,160 –> 00:39:58,600
, ktore su na tomto obden poste,
a ukazuju, ze je to nielen bezpecne ale aj ucinne.

591
00:40:00,320 –> 00:40:02,880
“Som tak presvedceny, ze to skusim.

592
00:40:02,880 –> 00:40:05,400
Vcera som sa postil.

593
00:40:05,400 –> 00:40:07,360
Dnes budem jest.”

594
00:40:07,360 –> 00:40:11,000
Takze dufajme, ze sa dokazem
vratit … nejak lahko.

595
00:40:11,000 –> 00:40:15,040
Ooh, magicky mysterizozny vylet!
To sa mi paci! Yeah, yeah!

596
00:40:15,040 –> 00:40:18,160
Hudba: “Johnny B Goode” od Chucka Berryho

597
00:40:27,120 –> 00:40:29,520
(ZVONEC) Ahoj, vdaka ze ste sa zastavili.

598
00:40:29,520 –> 00:40:31,360
Mozem vziat vasu objednavku, prosim?

599
00:40:31,360 –> 00:40:35,520
♪ Hlboko v Louisiane
V blizkosti New Orleans

600
00:40:35,520 –> 00:40:37,520
? Dalekov
lesoch medzi zelenacmi

601
00:40:37,520 –> 00:40:40,360
♪ Tam stalla kabinka
spravena zo zeminy a dreva

602
00:40:40,360 –> 00:40:42,800
? Tam zil
chlapec menom Johnny B. Goode. ?

603
00:40:42,800 –> 00:40:44,160
Velmi dobra volba!

604
00:40:44,160 –> 00:40:47,040
Obzvlast sa mi paci to mnozstvo
cohosi zeleneho vytrcajuceho z boku.

605
00:40:47,040 –> 00:40:48,600
Takze, musim priznat,

606
00:40:48,600 –> 00:40:52,440
som prekvapeny, ze som tu s vami.

607
00:40:52,440 –> 00:40:55,760
Tak nejako som si predstavoval, ze sa budete
drzat, no,

608
00:40:55,760 –> 00:40:58,080
viete, nejakej vegetarianskej diety
alebo takeho niecoho.

609
00:40:58,080 –> 00:41:00,760
Alebo, jest vela salatov
alebo niecoho take v dnoch ked sa moze jest, nie?

610
00:41:00,760 –> 00:41:04,920
Nie, vlastne je to tak, ze pokial sa budete drzat
toho, ze dosiahnete svoj kaloricky ciel v postnom dni,

611
00:41:04,920 –> 00:41:09,400
tak mozete doslova jest co
sa vam paci v tych dnoch ked sa je neobmedzene.

612
00:41:09,400 –> 00:41:13,680
“V jednej z najnovsich studii
Krista porovnavala dve skupiny na obden diete,

613
00:41:13,680 –> 00:41:16,560
“Jedna konzumovala jedla s vysokym, druha zase s nizkym obsahom tuku,

614
00:41:16,560 –> 00:41:18,960
pocaj dni jedenia.”

615
00:41:18,960 –> 00:41:21,120
Mne ide o moju hladinu glukozy v krvi,

616
00:41:21,120 –> 00:41:23,000
a tiez o moj cholesterol,

617
00:41:23,000 –> 00:41:25,440
A mam obavy o
vela inych veci. Ano, ano.

618
00:41:25,440 –> 00:41:29,240
Neovlyvnim teda nejako negativne toto vsetko
tym, ze budem jest jedla s vysokym obsahom tuku?

619
00:41:29,240 –> 00:41:31,320
To je vlastne to, co
sme si tiez mysleli, ze sa stane.

620
00:41:31,320 –> 00:41:32,640
Ale potom, prekvapujuco,

621
00:41:32,640 –> 00:41:35,000
zistili sme, ze vidime rovnaky pokles
LDL cholesterolu,

622
00:41:35,000 –> 00:41:36,880
to je ten zly cholesterol,

623
00:41:36,880 –> 00:41:38,600
a tiez triglyceridov,

624
00:41:38,600 –> 00:41:40,800
a krvneho tlaku.

625
00:41:40,800 –> 00:41:43,000
Takze, pokial ide o
riziko kardiovaskularnych ochoreni,

626
00:41:43,000 –> 00:41:45,600
nezalezalo na tom, ci ste
jedli jedlo s vysokym obsahom tuku alebo s nizkym obsahom tuku.

627
00:41:45,600 –> 00:41:50,200
Dalsim velkym prekvapenim bolo,
, ze po dni postu,

628
00:41:50,200 –> 00:41:54,280
sa ludia len zriedka prejedali
v dni kde mohli jest co len chceli.

629
00:41:57,680 –> 00:42:01,320
Takze, ked sme chceli aby ludia jedli len 25%
ich energetickych potrieb v ich postny den,

630
00:42:01,320 –> 00:42:03,880
tak sme si mysleli, ze ked
rozbehneme tuto studiu,

631
00:42:03,880 –> 00:42:05,920
ze ludia budu jest 175% na druhy den.

632
00:42:05,920 –> 00:42:09,120
Ale hned od
zaciatku, bez ohladu na okolnosti,

633
00:42:09,120 –> 00:42:13,840
ludia jednoducho nedokazali zjest
o 175% viac na dalsi den po poste.

634
00:42:13,840 –> 00:42:16,320
Vacsina ludi jedla v priemere len okolo 110%.

635
00:42:16,320 –> 00:42:18,880
Takze len nieco malo naviac nez
zvycajne jedavaju normalne.

636
00:42:18,880 –> 00:42:21,320
Z vysledkov sa zda ze tempo
procesu starnutia sa ale spomalilo,

637
00:42:21,320 –> 00:42:23,000
a tiez choroby s tym spojene.

638
00:42:23,000 –> 00:42:25,600
Znizuje to riziko
pridruzenych ochoreni,

639
00:42:25,600 –> 00:42:28,120
co je neuveritelna
vec. Ano, absolutne.

640
00:42:33,640 –> 00:42:37,200
Kristin vyskum je
stale v pociatocnych fazach.

641
00:42:37,200 –> 00:42:40,360
Ale z toho, co som videl a zazil,

642
00:42:40,360 –> 00:42:42,520
mam pocit, ze nadomnou uz vitazi

643
00:42:42,520 –> 00:42:45,360
myslienka, ze jednoduchy vzorec

644
00:42:45,360 –> 00:42:49,040
striedania postu s jedenim, moze byt velmi silnym liekom.

645
00:42:49,040 –> 00:42:54,000
Zda sa, ze to moze mat vplyvy, ktore
presahuju jednoducho to ze clovek je menej konzumuje.

646
00:42:54,000 –> 00:42:57,240
A myslim, ze toto by mohlo
fungovat pre niekoho ako som ja.

647
00:43:03,080 –> 00:43:05,920
Moja posledna zastavka je v Baltimore.

648
00:43:05,920 –> 00:43:09,520
Som tu, pretoze potrebujem
posledny kusok motivacie.

649
00:43:12,560 –> 00:43:17,240
Je tu jeden aspekt starnutia
ktory je pre mna najviac desivy, viac nez akykolvek iny.

650
00:43:17,240 –> 00:43:21,320
Ucinky starnutia prejavujuce sa na mojom mozgu.

651
00:43:24,280 –> 00:43:27,440
Snazim sa dohnat
profesora Marka Mattsona.

652
00:43:27,440 –> 00:43:31,840
Mark je poprednym odbornikom
na starnutie mozgu.

653
00:43:31,840 –> 00:43:34,960
Jeho vyskumy naznacuju, ze post

654
00:43:34,960 –> 00:43:37,800
moze pomoct oddialit nastup ochorenia

655
00:43:37,800 –> 00:43:40,520
ako je napriklad Alzheimerova choroba,
demencia, a strata pamati.

656
00:43:40,520 –> 00:43:41,680
Velmi dobre! A ako sa mate vy?

657
00:43:41,680 –> 00:43:44,560
Ahoj! Michael Mosley. Mark Mattson.

658
00:43:44,560 –> 00:43:47,520
Vy tu pracujete? Pracovat tu? Nie!

659
00:43:47,520 –> 00:43:50,840
Tiez nepracujem
tu! (MICHAEL sa zasmial).

660
00:43:50,840 –> 00:43:54,800
OK, Michael. Potrebujeme
aby ste si tu obuli topanky!

661
00:43:56,520 –> 00:43:59,880
Mierime dolu do suterenu

662
00:43:59,880 –> 00:44:03,080
Narodneho Institutu pre Vyskum Starnutia.

663
00:44:03,080 –> 00:44:04,280
OK? Ano.

664
00:44:04,280 –> 00:44:06,000
Schovana tu dole,

665
00:44:06,000 –> 00:44:09,720
je jedna specialna mys
ktoru mi chce ukazat.

666
00:44:17,680 –> 00:44:20,400
Tato mys preskumava bludisko.

667
00:44:22,800 –> 00:44:25,680
Je to test pamate, vytvoreny tak
aby sme videli, ako dobre si mys zapamata

668
00:44:25,680 –> 00:44:28,840
kde nasla predtym jedlo.

669
00:44:28,840 –> 00:44:32,000
Takze jedlo je skutocne v
bludisku, ano? Jedlo je tu.

670
00:44:32,000 –> 00:44:35,920
Mysi, ktore studuju, su modifikovane
tak aby sa u nich rozvinula Alzheimerova choroba.

671
00:44:38,440 –> 00:44:41,560
Normalne tejto chorobe podlahnu v ramci
pomerne kratkej doby,

672
00:44:41,560 –> 00:44:44,360
ale ked su tieto mysi na obden diete pozostavajucej

673
00:44:44,360 –> 00:44:47,160
z postnych dni a dni jedenia,

674
00:44:47,160 –> 00:44:50,120
co Mark nazyva “prerusovanym
dnom obmedzenia energie”,

675
00:44:50,120 –> 00:44:51,840
vysledky su uplne neuveritelne.

676
00:44:51,840 –> 00:44:55,680
.. a to take, ze zvierata na
prerusovanom energetickom obmedzeni,

677
00:44:55,680 –> 00:44:58,240
ziju ovela dlhsie normalnym zivotom,

678
00:44:58,240 –> 00:44:59,880
aspon, z toho co zatial dokazeme testovat,

679
00:44:59,880 –> 00:45:03,560
cize normalne sa ucia a normalne si pamataju,
, nez zacnu mat nejake problemy.

680
00:45:03,560 –> 00:45:05,280
Vyrazne dlhsie?

681
00:45:05,280 –> 00:45:07,480
Ano, velmi vyrazne.

682
00:45:07,480 –> 00:45:10,600
V jednej studii,
sa ukazalo ze to je medzi sest mesiacov az jeden rok dlhsie.

683
00:45:10,600 –> 00:45:14,280
To by bol ekvivalent
u cloveka s

684
00:45:14,280 –> 00:45:17,280
rozvojovymi znamkami Alzheimerovej choroby,
ci dostane chorobu vo veku 50,

685
00:45:17,280 –> 00:45:20,760
alebo az vo veku 80-tich rokov? Tak
zhruba? Je to pravda? Ano.

686
00:45:20,760 –> 00:45:24,160
“Na druhej strane, ked
mysi jedli zlu stravu,

687
00:45:24,160 –> 00:45:27,640
ide to s nimi dole vodou rychlo.”

688
00:45:27,640 –> 00:45:30,920
Davame im… Vela sladkych
napojov? A dietu s vysokym obsahom tukov, presne.

689
00:45:30,920 –> 00:45:32,880
A tiez im pridavame fruktozu
do ich pitnej vody,

690
00:45:32,880 –> 00:45:35,520
a to ma uplne dramaticky ucinok.

691
00:45:35,520 –> 00:45:37,920
Tieto zvierata maju este skorsi nastup choroby

692
00:45:37,920 –> 00:45:40,280
a problem s ucenim a pamatou.

693
00:45:40,280 –> 00:45:41,720
Je to ovela skor?

694
00:45:41,720 –> 00:45:44,880
Tak zhruba uz v styroch mesiacoch. Wow.

695
00:45:44,880 –> 00:45:48,760
Takze to je ekvivalent
vzniku Alzheimerovej choroby

696
00:45:48,760 –> 00:45:51,360
uz po 30tke, tesne pred 40tim rokom u cloveka? Presne!

697
00:45:51,360 –> 00:45:55,120
Zatial, sa robili len
studie na mysiach,

698
00:45:55,120 –> 00:45:58,040
ale uz sa planuje
testovanie aj na ludoch.

699
00:45:58,040 –> 00:46:00,400
Ake su dokazy
ze ak by niekto som ja

700
00:46:00,400 –> 00:46:02,520
zacal prerusovane hladovanie,

701
00:46:02,520 –> 00:46:05,520
ze by to znizilo jeho riziko
ochorenia mozgu, zhruba?

702
00:46:07,640 –> 00:46:10,000
Myslim, ze z ludskeho hladiska,

703
00:46:10,000 –> 00:46:16,000
ak pojdeme na stupnici od
zlej pravdepodobnosti az k velmi dobrej,

704
00:46:16,000 –> 00:46:18,080
a od vybornej az k vynikajucej,

705
00:46:18,080 –> 00:46:20,400
bolo by to niekde medzi velmi dobrou
az vynikajucou pravdepodobnostou.

706
00:46:21,760 –> 00:46:24,720
To je sposob, akym by som to kategorizoval ja.

707
00:46:29,560 –> 00:46:31,320
Ale, ako to vlastne funguje?

708
00:46:33,440 –> 00:46:36,120
No, ked sme skumali
mozgove tkanivo mysi na poste,

709
00:46:36,120 –> 00:46:39,440
nasli sme nieco uplne mimoriadne.

710
00:46:39,440 –> 00:46:44,920
Tieto zelene objekty
su novonarodene mozgove bunky.

711
00:46:44,920 –> 00:46:47,080
Tieto tri tu su uplne nove?

712
00:46:47,080 –> 00:46:53,600
Zda sa ze sporadicke hladovky
sposobuju vznik novych neuronov.

713
00:46:53,600 –> 00:46:57,160
Preco by mozog zacal vytvarat

714
00:46:57,160 –> 00:47:00,000
nove nervove bunky, ked
mu prestaneme davat jedlo?

715
00:47:00,000 –> 00:47:03,240
No, ak nad tym uvazujete
z evolucneho hladiska, dava zmysel,

716
00:47:03,240 –> 00:47:09,040
ze ak mate hlad, treba radsej
zvysit kognitivne schopnosti.

717
00:47:09,040 –> 00:47:11,280
Tie vam daju najlepsiu sancu na prezitie, je vyhoda,

718
00:47:11,280 –> 00:47:15,000
ak si ho pamatate, kde
ste naposledy videli alebo schovali potravu, atd.

719
00:47:17,040 –> 00:47:22,760
Zda sa, ze post cvici sedu mozgovu koru
podobne, ako cvicenie cvici svaly.

720
00:47:25,480 –> 00:47:30,160
Takze hlad vas robi
bystrejsim, mudrejsimi? Ano. Myslime si, ze ano.

721
00:47:34,080 –> 00:47:39,280
Markov vyskum vedie
k jednoduchemu uzaveru.

722
00:47:39,280 –> 00:47:43,600
Drzanie postu kazdy druhy den ma
lepsie ucinky na mozog

723
00:47:43,600 –> 00:47:47,480
nez keby clovek len celkovo
znizil prijem dennych kalorii.

724
00:47:47,480 –> 00:47:53,280
Je to pravda na mysiach, ale potrebujeme
lepsie studie, aby sme dokazali, ze sa to tyka aj ludi.

725
00:47:57,840 –> 00:48:02,000
Prisiel som na koniec mojho hladania ako
zistit co jest, ako sa postit a zit tak dlhsie.

726
00:48:03,200 –> 00:48:07,600
Oficialna rada je, jest
aspon 2,000 kalorii denne,

727
00:48:07,600 –> 00:48:11,640
ale ak naozaj chcete skusit post,
dokonca co len na striedavom zaklade,

728
00:48:11,640 –> 00:48:15,920
chodte najprv k doktorovi,
lebo su ludia, ktorym by to mohlo ublizit,

729
00:48:15,920 –> 00:48:19,560
ako su napriklad tehotne zeny alebo,
ludia trpiaci pod-vahou.

730
00:48:21,200 –> 00:48:25,960
Ja budem opatrny, a rozhodol som sa
ze skusim vzor, ktory mi odporucil Mark.

731
00:48:25,960 –> 00:48:31,680
Nie kazdy druhy den post, ale
menej extremnu verziu 5+2 dietu –

732
00:48:31,680 –> 00:48:37,080
cize mozem jest 5 dni, co bude nasledovane
dvoma dnami postu, a toto robit kazdy tyzden.

733
00:48:38,360 –> 00:48:43,720
Dnes je moj posledny den v Spojenych statoch, a
uplne mi to otvorilo oci.

734
00:48:43,720 –> 00:48:48,480
Nemal som tusenie, ze vobec existovalo
tolko vyskumu na temu

735
00:48:48,480 –> 00:48:54,200
postu, kalorickeho obmedzovania, vo vsetkych
takychto formach, a celkovo tolko vyskumu o starnuti.

736
00:48:55,200 –> 00:48:59,960
Rozhodol som sa ale, ze sa rozhodne
pokusim drzat mojho 5+2 programu,

737
00:48:59,960 –> 00:49:05,200
ako vravim, je to pat dni jedenia,
a potom dva dni na 600 kaloriach denne.

738
00:49:05,200 –> 00:49:07,760
Naozaj, naozaj dufam, ze
to pre mna spravi nejaky rozdiel,

739
00:49:07,760 –> 00:49:11,360
pretoze som si vedomy, ze uz teraz
som naozaj na konci zrazu

740
00:49:11,360 –> 00:49:14,720
ktory je mojou vstupenkov
k velmi strmemu vstupu do staroby,

741
00:49:14,720 –> 00:49:19,560
a teda ak je nieco, co moze
spomalit proces starnutia a dat mi

742
00:49:19,560 –> 00:49:25,360
viac rokov zdraveho zivota,
potom by som to naozaj rad vyskusal.

743
00:49:31,000 –> 00:49:35,280
Idem domov do Velkej Britanie.

744
00:49:35,280 –> 00:49:40,560
Rozhodol som sa, ze si dam pat
tyzdnov na to aby som si zvykol na moju novu dietu,

745
00:49:40,560 –> 00:49:43,760
a uvidime, ci dosiahnem nejake vysledky.

746
00:49:49,760 –> 00:49:52,520
To je
jeden z mojich postnych dni,

747
00:49:52,520 –> 00:49:55,240
a rozhodol som sa, ze
ranajky budu mojim hlavnym jedlom dna.

748
00:49:55,240 –> 00:49:59,440
Aj ked teda Mark Mattson povedal, ze
si nemysli, ze zalezi na tom

749
00:49:59,440 –> 00:50:01,760
kedy clovek zje nadelene
kalorie v jeho postnom dni.

750
00:50:01,760 –> 00:50:05,280
Snazil som sa rozne veci, ale
pre mna je to doslova znicujuce

751
00:50:05,280 –> 00:50:07,840
ist do prace, ked
mam hlad.

752
00:50:09,640 –> 00:50:12,480
Je tu dalsi dovod, preco som
rozhodol sa vyskusat tento rezim.

753
00:50:12,480 –> 00:50:16,040
Ked som prisiel domov, dal som si
spravit dalsi IGF-1 test.

754
00:50:17,040 –> 00:50:21,280
Bohuzial, moja uroven
bola zase vysoka, ako aj predtym.

755
00:50:21,280 –> 00:50:27,800
Ukazalo sa, ze tazko ziskane ucinky
stvordnoveho postu, trvali len velmi kratku chvilu.

756
00:50:27,800 –> 00:50:30,680
Aj ona si uz na to zvykla,
v tejto chvili, aspon myslim…

757
00:50:30,680 –> 00:50:33,920
Takze dufam, ze je to
nieco, co uz dokazem vydrzat. ”

758
00:50:33,920 –> 00:50:37,280
Dobre. Je to v pohode. Je
dvadsat minut do dvoch,

759
00:50:37,280 –> 00:50:41,040
a necitim sa ani trochu hladny
, ale je cas obeda,

760
00:50:41,040 –> 00:50:44,920
takze ked uz nic ine, myslim, ze
sa pojdem aspon prejst.

761
00:50:44,920 –> 00:50:50,680
HUDBA: “Harder, Better,
Rychlejsie, silnejsie” od Daft Punk

762
00:51:02,400 –> 00:51:06,840
Zistil som, ze postne dni
ked mam vela prace v robote, znasam lahsie,

763
00:51:06,840 –> 00:51:09,720
ale mojim velkym testom bude dovolenka.

764
00:51:09,720 –> 00:51:11,880
Prechadzam sa s priatelmi.

765
00:51:11,880 –> 00:51:17,080
Robime prechod cez
Trans-Pennine Way.

766
00:51:17,080 –> 00:51:22,080
Mal som ranajky toto rano
asi pred dvoma hodinami,

767
00:51:22,080 –> 00:51:28,200
a dalsi plan jest
je az na ranajky zajtra rano.

768
00:51:28,200 –> 00:51:32,160
Zatial sa citim celkom dobre.

769
00:51:35,080 –> 00:51:39,960
Teraz je asi 7 hodin.
Nejedol som nic uz 12 hodin.

770
00:51:39,960 –> 00:51:43,520
Ostatny su za mnou
a jedia v tejto krcmicke,

771
00:51:43,520 –> 00:51:47,640
tak som sa rozhodol ist
vonku na chvilku, pretoze …

772
00:51:47,640 –> 00:51:50,400
nie som taky silny, ako
som si myslel ze budem.

773
00:51:50,400 –> 00:51:53,480
Moj zaludok zacina pracovat
, ale to je v poriadku.

774
00:51:57,880 –> 00:52:02,400
“Je to uz pat tyzdnov od
co som zacal 5+2 dietu.”

775
00:52:02,400 –> 00:52:04,720
K nohe! K nohe!

776
00:52:04,720 –> 00:52:06,920
Toto je teda za psa!

777
00:52:06,920 –> 00:52:10,520
“Podarilo sa mi zmestit do dvoch 600
kaloriovych dni v tyzdni,

778
00:52:10,520 –> 00:52:13,960
“Hoci myslim ze by som inklinoval
k tomu aby boli tie postne dni trosku viac od seba.

779
00:52:13,960 –> 00:52:16,440
Ale bolo toto vsetko dost na to
aby to spravilo rozdiel? ”

780
00:52:17,840 –> 00:52:19,640
Dnes je den, ked uvidim svoje vysledky.

781
00:52:19,640 –> 00:52:21,520
Stratil som, co vidim, nejaku tu vahu,

782
00:52:21,520 –> 00:52:25,000
Zistim za okamih presne
kolko vahy, ale co ma najviac zaujima

783
00:52:25,000 –> 00:52:29,200
su krvne vysledky, pretoze vysledky z 5-6
tyzdnov dozadu boli vcelku hrozne.

784
00:52:29,200 –> 00:52:34,280
Mam vysoku glukozu,
vysoky cholesterol, a vysoku hladinu IGF.

785
00:52:34,280 –> 00:52:37,480
A tak sa uz naozaj, ale naozaj
neviem dockat, aby som videl ci sa nieco zlepsilo,

786
00:52:37,480 –> 00:52:41,400
pretoze aby som bol uprimny, ak sa to
nezlepsilo, mam na ruke dost velky problem,

787
00:52:41,400 –> 00:52:46,480
ja totiz chcem zostat mlady a
zdravy pre moju rodinu, ale aj pre seba.

788
00:52:46,480 –> 00:52:51,800
A tak som celkom nervozny, pretoze
mi na tom strasne moc zalezi.

789
00:52:55,000 –> 00:52:59,080
Len pre pripomenutie, toto je ako som
vyzeral na zaciatku tohto filmu.

790
00:53:01,160 –> 00:53:04,040
A takto vyzeram dnes.

791
00:53:04,040 –> 00:53:06,640
Musel som si pridat niekolko
novych dierok na opasok,

792
00:53:06,640 –> 00:53:09,800
takze viem, ze sa nieco
zmenilo, ale ako a o kolko?

793
00:53:09,800 –> 00:53:14,400
Jasne, a je tu okamih pravdy, v ktorom som
zistil, kolko vahy som vlastne stratil.

794
00:53:14,400 –> 00:53:18,360
Toto je specialny druh vahy ktory
zmeria moju vahu velmi presne,

795
00:53:18,360 –> 00:53:20,280
a tiez zisti kolko ma moje telo tuku.

796
00:53:20,280 –> 00:53:23,280
Hey! Tak to je fantasticke!

797
00:53:23,280 –> 00:53:31,240
To je 78kg, co znamena, ze
som stratil skoro 6.5 kila.

798
00:53:31,240 –> 00:53:36,280
Moje telesny tuk, ked som
zacal bol na 27%,

799
00:53:36,280 –> 00:53:39,440
a teraz je to menej ako 20.

800
00:53:39,440 –> 00:53:42,560
To je naozaj, ale naozaj potesujuce.

801
00:53:46,280 –> 00:53:50,960
Citim sa dobre, a
rodina hovori ze vyzeram chudsie.

802
00:53:50,960 –> 00:53:54,120
A naozaj to nebolo tak tazke,

803
00:53:54,120 –> 00:53:58,280
a som rad, ze som uz opat v
normalnej vahovej kategorii.

804
00:53:58,280 –> 00:54:02,400
Ale to, co naozaj chcem vediet
je to, co sa zmenilo vo vnutri mojho tela.

805
00:54:06,920 –> 00:54:12,280
Profesor Luigi Fontana mi akurat
ide zavolat so svojimi konecnymi vysledkami.

806
00:54:12,280 –> 00:54:15,160
Ahoj, Michael! Ahoj, Luigi, ako sa mas?

807
00:54:15,160 –> 00:54:17,680
Som v poriadku, a ty? Mam sa velmi dobre.

808
00:54:17,680 –> 00:54:19,200
Takze, mame tvoje vysledky.

809
00:54:19,200 –> 00:54:23,880
Len tym ze si sa postil 2 dni do
tyzna, si spravil nieco uzasne

810
00:54:23,880 –> 00:54:28,760
pre tvoje kardio-metabolicke zdravie,
a tak som na teba velmi hrdy.

811
00:54:28,760 –> 00:54:33,920
‘Ale co sa stalo s mojim IGF-1?
Je moje telo este stale v rychlo-rychlo mode?’

812
00:54:33,920 –> 00:54:38,760
IGF-1 je hlavnym
rizikovym faktorom pre rakovinu.

813
00:54:38,760 –> 00:54:42,080
Rakovina prsnika, rakovina prostaty
, rakovina hrubeho creva.

814
00:54:42,080 –> 00:54:45,480
Obidva, tri a pol
dnovy post

815
00:54:45,480 –> 00:54:51,840
a tiez post zlozeny z piatich tyzdnov prerusovanej
hladovky Vam sposobil celkovy pokles IGF-1 o 50%.

816
00:54:53,360 –> 00:54:56,600
“Co je dostatocne k obmedzeniu
rizik viacerych druhov rakoviny.

817
00:54:56,600 –> 00:55:00,240
“Ale co moja hladina cukru v krvi,
ktora hranicila s cukrovkou? ”

818
00:55:00,240 –> 00:55:05,560
Vasa glukoza klesla
na 90. Tak veru. Fantasticke.

819
00:55:05,560 –> 00:55:07,640
Takze vasa glukozy je na normale.

820
00:55:07,640 –> 00:55:10,760
“Moj konecny vysledok je cholesterol.”

821
00:55:10,760 –> 00:55:15,320
Takze, tu ste mali znizenie
celkoveho cholesterolu,

822
00:55:15,320 –> 00:55:17,840
a zvysil sa vam
dobry cholesterol.

823
00:55:17,840 –> 00:55:21,920
To ukazuje, ako kratko
to trva, vidite,

824
00:55:21,920 –> 00:55:26,160
dojst k celkovemu zlepseniu a to bez drog,
a bez uzivania liekov.

825
00:55:26,160 –> 00:55:29,120
“Nebolo to bez usilia,

826
00:55:29,120 –> 00:55:34,520
ale znizil som riziko vzniku
chorob, ktore by mi mohli skratit zivot. ”

827
00:55:34,520 –> 00:55:37,680
Dakujem. Takze, by som mal zit
zdravo a stastne az do smrti, ze?

828
00:55:37,680 –> 00:55:40,200
Neviem ci budete zit
stastnejsie,

829
00:55:40,200 –> 00:55:44,200
ale mate nizsie riziko
toho ze sa u vas rozvinie nejake ochorenie.

830
00:55:44,200 –> 00:55:47,440
Velmi vam dakujem, Luigi,
Naozaj, dakujem. Nie je zac.

831
00:55:47,440 –> 00:55:50,600
Som velmi, velmi spokojny.
Velmi spokojny naozaj.

832
00:55:50,600 –> 00:55:53,920
To bolo ovela lepsie
nez som ocakaval.

833
00:55:55,400 –> 00:56:00,520
‘Chcel som aby moja zena Claire, ktora
je tiez doktorkou, videla moje vysledky.’

834
00:56:00,520 –> 00:56:05,840
Takze, toto je moje IGF, ktory je
rizikom pre rakovinu a vznik inych chorob.

835
00:56:05,840 –> 00:56:10,440
Toto zislo dole na polovicu
len mojim dvojdnovym postenim. Ano.

836
00:56:10,440 –> 00:56:14,560
Vsetko ukazuje zlepsenie
v ktore si dufal.

837
00:56:14,560 –> 00:56:15,720
Ano.

838
00:56:15,720 –> 00:56:19,040
To v podstate znamena, ze nebudem
musiet brat ziadne tablety, aspon v sucasnej dobe.

839
00:56:19,040 –> 00:56:20,280
Nie. Ale iba ak vydrzis svoj postny plan.

840
00:56:21,400 –> 00:56:24,080
No, vyzeras ale, ze ti velmi prospieva.

841
00:56:24,080 –> 00:56:26,160
Dakujem. Som naozaj spokojny.

842
00:56:26,160 –> 00:56:28,960
Musim povedat, ze to su naozaj,
uzasne dobre spravy. Hm.

843
00:56:33,400 –> 00:56:37,840
Vysledky boli
absolutne fantasticke pre mna sameho,

844
00:56:37,840 –> 00:56:42,000
ale, neznamena to, ze prerusovany
post bude pracovat pre kazdeho.

845
00:56:44,200 –> 00:56:48,200
Je naozaj dolezite, aby
sa urobilo viac studii na ludoch,

846
00:56:48,200 –> 00:56:51,320
a zistilo, ci je toto dlhodobo
bezpecne a efektivne.

847
00:56:53,760 –> 00:56:58,760
Ale tym ze som zazil prerusovany
post, mam v plane v nom pokracovat.

848
00:56:59,880 –> 00:57:03,240
Zda sa, ze to opravilo
niektore skody

849
00:57:03,240 –> 00:57:05,880
ktore som svojmu
telu sposobil za tie roky.

850
00:57:08,920 –> 00:57:12,040
Je velmi dojemne sa pozerat
na fotografie seba

851
00:57:12,040 –> 00:57:15,160
a clenov mojej rodiny
ako casom rastieme a starneme,

852
00:57:15,160 –> 00:57:18,640
ale neznamena to, ze
chcem zadrzat tok casu.

853
00:57:18,640 –> 00:57:23,920
Tak nejako viem ze starneme
a mali by sme zostarnut,

854
00:57:23,920 –> 00:57:26,920
a ze je len velmi malo co
s tym mozeme urobit.

855
00:57:26,920 –> 00:57:31,680
Ale post je trosku ina vec. Post
nie je o snahe zit do 140-tich rokov,

856
00:57:31,680 –> 00:57:35,880
Je to o tom zostat zdravy
tak dlho, ako je to len mozne,

857
00:57:35,880 –> 00:57:39,280
a momentalna doba,
ktorej celime ako narod,

858
00:57:39,280 –> 00:57:42,240
ked zapasime s obezitou
a je tu coraz viac cukrovkarov,

859
00:57:42,240 –> 00:57:45,960
zufalo potrebuje nieco
co moze spravit rozdiel.

860
00:57:45,960 –> 00:57:49,480
Post je prva vec
s ktorou som sa oboznamil

861
00:57:49,480 –> 00:57:52,840
o ktorej som skutocne presvedceny, ze
keby to ludia vyskusali, dali tomu sancu,

862
00:57:52,840 –> 00:57:56,840
mohlo by to radikalne zmenit
nase celo-narodne zdravie.

863
00:57:56,840 –> 00:58:03,360
Takze, dufam, ze budeme aj nadalej pokracovat
v masivnom vyskume a prieskume tohoto uzemia.

864
00:58:04,560 –> 00:58:08,240
Robit tento post
bola jedna z najzaujimavejsich veci …

865
00:58:08,240 –> 00:58:11,600
no, povedal by som, absolutne
naj-zaujimavejsia cesta na ktoru som sa podujal, ci filmoval,

866
00:58:11,600 –> 00:58:14,240
alebo ako to len chcete nazvat
,… cesta ktorej som sa zucastnil.

867
00:58:14,240 –> 00:58:16,320
(Pes knuci)

868
00:58:16,320 –> 00:58:18,520
A nieco take som nikdy predtym este nepovedal.

869
00:58:32,000 –> 00:58:35,640
Slovenske Titulky: Jozef Jarosciak ml.

——–
——–
Anglicke Titulky:

1
00:00:07,040 –> 00:00:09,000
I love life,

2
00:00:09,000 –> 00:00:13,280
so I want to remain young, energetic,
enjoy it for as long as I can.

3
00:00:13,280 –> 00:00:15,480
I’m medically trained.

4
00:00:15,480 –> 00:00:19,360
I know all the standard
advice for staying healthy.

5
00:00:19,360 –> 00:00:23,120
But in my case, it
doesn’t seem to be working.

6
00:00:24,760 –> 00:00:29,800
I’ve discovered that my body is
not the lean, long-lived machine

7
00:00:29,800 –> 00:00:31,800
I would like it to be.

8
00:00:31,800 –> 00:00:37,480
A third of your body is fat. Thank
you…for making that point so emphatically.

9
00:00:37,480 –> 00:00:42,400
I wanted to see if science can offer
a different way to stop the rot,

10
00:00:42,400 –> 00:00:44,560
slow the clock,

11
00:00:44,560 –> 00:00:48,000
so I set off to find experts

12
00:00:48,000 –> 00:00:51,520
who are trying to combat
the ravages of ageing.

13
00:00:51,520 –> 00:00:54,760
We are rewriting human
physiology here. Ooh…yay!

14
00:00:56,160 –> 00:01:00,440
If you can find something else that you can
do that it doesn’t hurt you, that benefits you

15
00:01:00,440 –> 00:01:03,440
and that causes these
changes, I’d like to know.

16
00:01:05,160 –> 00:01:08,200
What I discovered was truly surprising.

17
00:01:09,800 –> 00:01:14,640
It involves no pills, no
injections and no hidden cost.

18
00:01:14,640 –> 00:01:17,400
It’s all a question of what you eat.

19
00:01:17,400 –> 00:01:19,400
Or rather, what you don’t eat.

20
00:01:20,920 –> 00:01:25,480
Last night, I dreamt I ate a sandwich
and then I felt fantastically guilty.

21
00:01:25,480 –> 00:01:26,840
It’s about fasting.

22
00:01:26,840 –> 00:01:30,120
But fasting made easier.

23
00:01:30,120 –> 00:01:32,400
If I were to go onto Joe’s lifestyle…?

24
00:01:32,400 –> 00:01:36,200
In a year, you are going to be cured.

25
00:01:42,480 –> 00:01:48,600
The big thing is that this is the beginning
of something which I think could be huge.

26
00:01:48,600 –> 00:01:51,480
If it takes off and if it heads off
in the direction I imagine it will,

27
00:01:51,480 –> 00:01:54,920
then this…this could be
genuinely revolutionary.

28
00:02:10,840 –> 00:02:12,720
KLAXON

29
00:02:18,520 –> 00:02:23,160
There are plenty of people
who stay young and fit

30
00:02:23,160 –> 00:02:25,160
well beyond retirement age.

31
00:02:33,480 –> 00:02:36,320
They mainly do it the traditional way –

32
00:02:36,320 –> 00:02:39,120
through lots and lots of exercise.

33
00:02:39,120 –> 00:02:42,280
Today, I’ve come to the London Marathon.

34
00:02:42,280 –> 00:02:47,000
Nearly 36,000 bodies
of all shapes and sizes

35
00:02:47,000 –> 00:02:49,360
are tackling the 26-mile course.

36
00:02:49,360 –> 00:02:51,480
Some are young,

37
00:02:51,480 –> 00:02:53,400
many not so young.

38
00:03:00,560 –> 00:03:03,920
There’s an absolutely
fantastic atmosphere here.

39
00:03:03,920 –> 00:03:05,760
Now, I have never run the marathon

40
00:03:05,760 –> 00:03:08,560
and I have no plans to
ever run the marathon,

41
00:03:08,560 –> 00:03:12,160
but there are plenty
of people running today

42
00:03:12,160 –> 00:03:15,160
who are far older than me.

43
00:03:15,160 –> 00:03:18,880
There are 7,000 people in their 50s

44
00:03:18,880 –> 00:03:21,480
and, incredibly enough,

45
00:03:21,480 –> 00:03:25,560
there are seven people who
are in their 80s or older.

46
00:03:31,320 –> 00:03:35,280
I’m going to trying and
flag a few of them down

47
00:03:35,280 –> 00:03:37,200
to ask how they do it.

48
00:03:37,200 –> 00:03:39,560
Hello! How are you? Hello!

49
00:03:40,760 –> 00:03:42,720
How old are you? 78.

50
00:03:42,720 –> 00:03:44,360
And how old are you? 81.

51
00:03:50,960 –> 00:03:54,280
What’s the secret, then,
running? Magic wand!

52
00:03:54,280 –> 00:03:57,520
Just eating well. Hard
work son, that’s all!

53
00:03:59,120 –> 00:04:04,200
Anyone who can run a marathon
in their 70s deserves my respect,

54
00:04:04,200 –> 00:04:10,000
but I’m waiting for a man who
makes septuagenarians look youthful.

55
00:04:13,920 –> 00:04:16,440
Fauja Singh is amazing.

56
00:04:16,440 –> 00:04:19,120
He has been active all his life,

57
00:04:19,120 –> 00:04:22,800
but he only took up
serious running in his 80s.

58
00:04:22,800 –> 00:04:27,640
So what is it that keeps him
so remarkably fit and energetic?

59
00:04:27,640 –> 00:04:31,200
Hi, there. Nice to see you.

60
00:04:31,200 –> 00:04:34,080
How old is Fauja? 101.

61
00:04:34,080 –> 00:04:37,000
Born on 1st April 1911.

62
00:04:37,000 –> 00:04:41,000
Unfortunately he hasn’t quite
mastered the English language yet.

63
00:04:41,000 –> 00:04:44,200
Do you mind asking him how he’s feeling?

64
00:04:44,200 –> 00:04:46,360
THEY SPEAK IN PUNJABI

65
00:04:49,440 –> 00:04:51,680
He goes, “It’s not easy…” Yeah?

66
00:04:51,680 –> 00:04:56,960
But the job’s got to be done, cos he’s not
finished yet. You’re not going to give up, are you?

67
00:05:02,840 –> 00:05:05,200
Although he’s 101,

68
00:05:05,200 –> 00:05:09,160
Fauja has never had surgery,

69
00:05:09,160 –> 00:05:13,440
he shows no signs of heart disease…

70
00:05:13,440 –> 00:05:16,320
and he takes no medication.

71
00:05:20,160 –> 00:05:23,040
He believes that his long life

72
00:05:23,040 –> 00:05:26,240
and his incredible health
is down to his diet.

73
00:05:28,480 –> 00:05:30,680
So, any particular diet?

74
00:05:30,680 –> 00:05:33,200
He has no particular diet.

75
00:05:33,200 –> 00:05:39,200
It’s a simple Punjabi farmer’s
diet, so just fresh food,

76
00:05:39,200 –> 00:05:42,080
but his secret is that he
has smaller portions. Right.

77
00:05:42,080 –> 00:05:45,040
In poor countries,
people die of starvation.

78
00:05:45,040 –> 00:05:48,600
In rich countries,
people die of over-eating.

79
00:05:48,600 –> 00:05:52,080
So, how much does he
eat, compared to you or I?

80
00:05:52,080 –> 00:05:55,120
He would eat what would be
considered half a portion,

81
00:05:55,120 –> 00:05:57,640
almost a child’s portion.

82
00:05:57,640 –> 00:06:02,000
So a child portion is probably about half
the amount of calories you or I would eat?

83
00:06:04,840 –> 00:06:08,720
By restricting his food
intake so dramatically,

84
00:06:08,720 –> 00:06:12,960
Fauja has unknowingly been testing
a theory that has been around

85
00:06:12,960 –> 00:06:15,280
nearly as long as he has.

86
00:06:17,480 –> 00:06:21,680
A scientific theory which is only
now really coming into its own.

87
00:06:26,920 –> 00:06:30,720
I’ve taken the Tube to the finish line.

88
00:06:30,720 –> 00:06:33,760
I want to catch Fauja become, hopefully,

89
00:06:33,760 –> 00:06:36,960
the world’s oldest marathon runner.

90
00:06:44,880 –> 00:06:49,800
And after seven hours and
49 minutes, he succeeds.

91
00:06:49,800 –> 00:06:52,920
CHEERING AND APPLAUSE

92
00:06:55,760 –> 00:06:58,280
Can I congratulate you?

93
00:07:12,440 –> 00:07:15,960
That is absolutely unbelievable
– he’s 101 years old

94
00:07:15,960 –> 00:07:19,080
and he has just covered 26 miles.

95
00:07:19,080 –> 00:07:22,480
Now, I can’t imagine
that, in 50 years’ time,

96
00:07:22,480 –> 00:07:24,800
I’m going to be running down The Mall,

97
00:07:24,800 –> 00:07:27,200
but I want to be like him.

98
00:07:27,200 –> 00:07:32,080
I want to be mentally active and physically
active, I want to stay younger for longer.

99
00:07:42,680 –> 00:07:45,960
For decades, teams of
scientists around the world

100
00:07:45,960 –> 00:07:49,000
have been intensely studying ageing.

101
00:07:49,000 –> 00:07:55,560
Now, clearly, genes play a significant
part in how quickly and well we age,

102
00:07:55,560 –> 00:07:58,760
but there’s nothing much
you can do about your genes.

103
00:07:58,760 –> 00:08:03,000
There is, however, something
you can do about what you eat.

104
00:08:06,880 –> 00:08:11,960
And here in America, they are starting
to turn out some truly remarkable research

105
00:08:11,960 –> 00:08:14,600
linking food with longevity.

106
00:08:14,600 –> 00:08:20,200
It seems it’s not just about WHAT
we eat, but how and when we eat it.

107
00:08:22,040 –> 00:08:27,480
Our story begins in the dust
bowls of America during the 1930s.

108
00:08:27,480 –> 00:08:30,600
There was a terrible
drought, food was scarce,

109
00:08:30,600 –> 00:08:34,760
and the whole country was in the
grips of the Great Depression.

110
00:08:34,760 –> 00:08:37,480
Now, you would imagine,
in such difficult times,

111
00:08:37,480 –> 00:08:42,040
that life expectancy would
fall, but in fact it rose.

112
00:08:44,440 –> 00:08:49,600
During the darkest years of
Great Depression – 1929 to 1933 –

113
00:08:49,600 –> 00:08:53,960
life expectancy increased
by a remarkable six years.

114
00:08:59,320 –> 00:09:03,080
Now, on the face of it,
that is really surprising,

115
00:09:03,080 –> 00:09:08,760
and yet, clues as to why could also be
found from research done back in the 1930s.

116
00:09:09,920 –> 00:09:13,320
Nutritionists at Cornell
University working with animals

117
00:09:13,320 –> 00:09:15,720
discovered that if you severely restrict

118
00:09:15,720 –> 00:09:20,080
the amount they eat, they live longer.

119
00:09:20,080 –> 00:09:22,840
Much, much longer.

120
00:09:25,880 –> 00:09:30,640
So the next obvious question
– if you do the same with humans,

121
00:09:30,640 –> 00:09:33,680
will it have the same effects?

122
00:09:35,640 –> 00:09:39,920
Well, it’s been eight decades
since that observation,

123
00:09:39,920 –> 00:09:43,320
and only now are scientists
really beginning to understand

124
00:09:43,320 –> 00:09:47,360
the link between calorie
restriction and longevity in humans.

125
00:09:47,360 –> 00:09:51,880
At long last, it seems, we
are starting to get answers.

126
00:10:00,920 –> 00:10:06,000
Washington University is at
the heart of this new science.

127
00:10:06,000 –> 00:10:09,080
We are rewriting human physiology here!

128
00:10:09,080 –> 00:10:11,040
It’s astonishing, you know,

129
00:10:11,040 –> 00:10:14,920
how simple dietary
intervention can really change

130
00:10:14,920 –> 00:10:17,840
how the human body works, basically.

131
00:10:19,720 –> 00:10:24,120
‘Professor Luigi Fontana has spent the
last ten years studying a group of people

132
00:10:24,120 –> 00:10:28,520
‘who severely calorie
restrict every single day.

133
00:10:30,280 –> 00:10:33,400
‘And he is astonished
by what he’s found.’

134
00:10:34,920 –> 00:10:37,800
These people, they look
like a different species.

135
00:10:37,800 –> 00:10:40,240
That’s quite a big
statement, isn’t it? Yes!

136
00:10:40,240 –> 00:10:45,040
We are finding that they are going to
live longer than their parents and brothers

137
00:10:45,040 –> 00:10:48,080
on the typical American
diet, or Western diets.

138
00:10:53,440 –> 00:10:56,040
‘Luigi is clearly impressed,

139
00:10:56,040 –> 00:11:00,920
‘so I wanted to meet one of this
new species of human for myself.’

140
00:11:00,920 –> 00:11:04,800
A lovely, lovely house. Were the
directions good? Very good, thank you.

141
00:11:04,800 –> 00:11:07,280
Joe Cordell is a CRonie –

142
00:11:07,280 –> 00:11:10,640
a calorie restrictor
on optimal nutrition.

143
00:11:10,640 –> 00:11:14,240
And that means a lot of fruit and veg.

144
00:11:16,280 –> 00:11:18,800
I went ahead and kind
of put everything out

145
00:11:18,800 –> 00:11:22,920
because I thought you might want to have some
breakfast. That would be delicious, thank you.

146
00:11:22,920 –> 00:11:25,120
When I imagine a calorie restrictor,

147
00:11:25,120 –> 00:11:30,120
I imagine someone who lives basically on a
couple of carrots, or something like that.

148
00:11:30,120 –> 00:11:34,160
I didn’t think you’d
go in for breakfast.

149
00:11:34,160 –> 00:11:37,720
‘Joe kicks off his day
with a mountain of fruit,

150
00:11:37,720 –> 00:11:40,360
‘some of which he then throws away.’

151
00:11:41,360 –> 00:11:45,840
Then what I like to do is add some apple
to it, but when you’re in my position,

152
00:11:45,840 –> 00:11:50,840
I want to get as much nutritional
value as I can for the calorie,

153
00:11:50,840 –> 00:11:53,480
and virtually all the
nutritional value is in the peel.

154
00:11:53,480 –> 00:11:56,960
So you’re going to slip the peel
in and throw away the rest of it?

155
00:11:56,960 –> 00:11:59,960
You’re going to do the
reverse of what most people do.

156
00:11:59,960 –> 00:12:04,160
It’s great, because literally 95%
of the nutritional value here…

157
00:12:04,160 –> 00:12:07,840
Is in the skin? Yeah. The
rest is sugar and calories.

158
00:12:07,840 –> 00:12:11,480
This is generally what I’ll have
each morning The whole thing?

159
00:12:11,480 –> 00:12:13,080
Yeah. That’s a big bowl.

160
00:12:13,080 –> 00:12:17,360
Do you ever think, “What if I’m
wrong? What if it’s all wrong?

161
00:12:17,360 –> 00:12:22,360
“I’ve done this for 10, 20 years, and
then a new bit of science comes out

162
00:12:22,360 –> 00:12:25,200
“which says it’s actually all nonsense.”

163
00:12:25,200 –> 00:12:28,840
I tell you, my brother, who
weighs 100 lb more than I do,

164
00:12:28,840 –> 00:12:33,720
he’s about my age. He’s all
the time making the joke to me

165
00:12:33,720 –> 00:12:36,640
that he’s going to end up out-living me

166
00:12:36,640 –> 00:12:39,280
and, in his opinion, I will
have suffered for nothing.

167
00:12:39,280 –> 00:12:41,360
But the point is, I enjoy doing it.

168
00:12:41,360 –> 00:12:44,000
Living a healthy lifestyle is fun.

169
00:12:44,000 –> 00:12:49,080
‘There are an estimated
100,000 CRonies worldwide –

170
00:12:49,080 –> 00:12:53,680
‘people living on a diet
which is rich in nutrients

171
00:12:53,680 –> 00:12:55,520
‘but low in calories.

172
00:12:55,520 –> 00:12:59,080
‘Joe looks fit, but
not impressively young.

173
00:12:59,080 –> 00:13:02,160
‘Perhaps Luigi has been exaggerating.’

174
00:13:02,160 –> 00:13:05,480
What I’d love to do is take
you off and do a number of tests

175
00:13:05,480 –> 00:13:07,120
and see just how we compare.

176
00:13:07,120 –> 00:13:11,120
OK, I’m game. So, is this a challenge?

177
00:13:11,120 –> 00:13:16,040
This is a challenge indeed, a
challenge I suspect I may well lose!

178
00:13:20,040 –> 00:13:25,360
For a decade, Joe’s been
eating 1,900 calories a day.

179
00:13:25,360 –> 00:13:28,720
I’ve averaged around 2,300,

180
00:13:28,720 –> 00:13:31,560
quite a few of them donuts and burgers.

181
00:13:31,560 –> 00:13:33,880
How much do you think you weigh?

182
00:13:33,880 –> 00:13:37,640
Probably about 180. Ooh, more than 180!

183
00:13:37,640 –> 00:13:39,280
Breathe in!

184
00:13:39,280 –> 00:13:44,000
I should be around 134, 135, 136.

185
00:13:44,000 –> 00:13:46,480
We just have to move it down one notch.

186
00:13:46,480 –> 00:13:49,120
134. Oh, right on.

187
00:13:51,240 –> 00:13:55,320
We’re both in our 50s,
and I really don’t think

188
00:13:55,320 –> 00:13:58,680
we look like different
generations, let alone species.

189
00:13:58,680 –> 00:14:01,520
So how different are we?

190
00:14:01,520 –> 00:14:05,280
I just need for you to
relax. Sit still, no talking.

191
00:14:08,640 –> 00:14:12,880
Some of the simplest ways of assessing
ageing don’t need specialist equipment.

192
00:14:12,880 –> 00:14:14,240
Oh, this is good.

193
00:14:14,240 –> 00:14:17,040
Balance is controlled by your inner ear.

194
00:14:21,560 –> 00:14:24,600
‘As you age, ear structures deteriorate

195
00:14:24,600 –> 00:14:27,120
‘and your balance gets worse.

196
00:14:27,120 –> 00:14:30,920
One more. ‘You can test it
by standing on your weaker leg

197
00:14:30,920 –> 00:14:32,720
‘with your eyes closed.’

198
00:14:32,720 –> 00:14:36,360
How long did I make? 6.59
seconds. Not very good.

199
00:14:36,360 –> 00:14:38,360
‘Not good at all.

200
00:14:38,360 –> 00:14:41,920
‘The average 55-year-old
should manage 8 seconds.’

201
00:14:41,920 –> 00:14:43,760
You’re down to…

202
00:14:43,760 –> 00:14:47,720
Yeah, you’re doing well
for the average 20-year-old.

203
00:14:47,720 –> 00:14:50,400
Over 30 seconds is what
most 20-year-olds can manage,

204
00:14:50,400 –> 00:14:52,960
but it’s one of those skills
that drops off dramatically.

205
00:14:52,960 –> 00:14:56,680
I think you’ve proved a
point. Stop. You can stop, yes.

206
00:14:58,720 –> 00:15:03,040
‘Another good test is reaction
time, which drops off with age.’

207
00:15:03,040 –> 00:15:04,840
Not good. Eight.

208
00:15:04,840 –> 00:15:07,600
‘This one only needs a ruler.

209
00:15:07,600 –> 00:15:11,320
‘At our age, you should be able to
catch it around the five-inch mark.’

210
00:15:13,200 –> 00:15:16,680
Very good. That was 4. You’re
doing pretty well, I must admit.

211
00:15:21,480 –> 00:15:25,120
Luigi’s methods are
rather more scientific.

212
00:15:25,120 –> 00:15:28,600
We did a range of other medical tests,

213
00:15:28,600 –> 00:15:30,920
including blood tests.

214
00:15:30,920 –> 00:15:34,680
Now he’s about to give us our results.

215
00:15:34,680 –> 00:15:37,800
Feels like being in the
headmaster’s office, doesn’t it?

216
00:15:37,800 –> 00:15:39,200
Waiting for the results.

217
00:15:39,200 –> 00:15:43,160
Will you get an A-star?
Will I get a B-minus?

218
00:15:43,160 –> 00:15:45,080
‘Luigi’s face tells me

219
00:15:45,080 –> 00:15:48,480
‘that what I’m about to
hear is not good news.’

220
00:15:48,480 –> 00:15:53,600
Total body fat in Joseph is 11.5%.

221
00:15:53,600 –> 00:15:57,640
This is typical of a super athlete.

222
00:15:57,640 –> 00:16:01,000
11% body fat is very low

223
00:16:01,000 –> 00:16:04,720
for a 54-,
55-year-old man.

224
00:16:04,720 –> 00:16:07,360
Yours is 27.1% fat.

225
00:16:07,360 –> 00:16:09,240
A third of your body is fat.

226
00:16:09,240 –> 00:16:13,280
Thank you…for making
that point so emphatically!

227
00:16:13,280 –> 00:16:17,640
‘And he’s still not done
talking about my fat.’

228
00:16:17,640 –> 00:16:19,720
Abdominal fat is around 30%.

229
00:16:19,720 –> 00:16:23,760
Abdominal fat is really the bad guy.

230
00:16:23,760 –> 00:16:26,480
The higher the abdominal
fat, the higher the risk

231
00:16:26,480 –> 00:16:29,560
of developing type 2 diabetes,
cardiovascular disease.

232
00:16:29,560 –> 00:16:32,680
No doubt about it. It’s also
a risk factor for cancer.

233
00:16:33,880 –> 00:16:37,920
So, basically, your
cardiometabolic profile,

234
00:16:37,920 –> 00:16:39,920
it’s not good. For your age.

235
00:16:39,920 –> 00:16:42,400
I think you should do
something to improve it.

236
00:16:42,400 –> 00:16:44,800
What we can say is that Joseph

237
00:16:44,800 –> 00:16:48,280
is not going to develop
cardiovascular disease.

238
00:16:48,280 –> 00:16:50,480
It’s impossible to develop stroke,

239
00:16:50,480 –> 00:16:53,080
myocardial infarction or heart failure.

240
00:16:53,080 –> 00:16:56,080
These three diseases are responsible

241
00:16:56,080 –> 00:16:58,960
for 40% of the deaths now in US and UK.

242
00:16:58,960 –> 00:17:02,280
No chance he’ll die of that?
I mean, one in a million.

243
00:17:02,280 –> 00:17:06,040
And if I were to go
onto Joe’s lifestyle…?

244
00:17:06,040 –> 00:17:08,560
In a year, you are going to be cured.

245
00:17:12,360 –> 00:17:16,040
I now understand what Luigi means.

246
00:17:16,040 –> 00:17:20,600
It is as if we are
two different species.

247
00:17:20,600 –> 00:17:24,600
Joe’s diet seems to be keeping
his organs in pristine condition.

248
00:17:24,600 –> 00:17:28,080
My diet is undermining
my health, and fast.

249
00:17:30,480 –> 00:17:34,840
Well, that was very sobering.
Luigi does not mince his words.

250
00:17:34,840 –> 00:17:36,920
He talked a bit about abdominal fat.

251
00:17:36,920 –> 00:17:39,440
In fact, he talked quite a
lot about my abdominal fat.

252
00:17:39,440 –> 00:17:42,160
I’ve never thought of
myself as particularly fat.

253
00:17:42,160 –> 00:17:45,120
But it was the sort of two
visions he held out to me.

254
00:17:45,120 –> 00:17:48,240
One, where, if I continue
as I am at the moment,

255
00:17:48,240 –> 00:17:53,000
I’m heading almost certainly for
heart disease and possibly worse.

256
00:17:53,000 –> 00:17:57,720
The other is, if I embrace
the calorie restriction way,

257
00:17:57,720 –> 00:18:01,960
he said I could be effectively
cured in less than a year.

258
00:18:01,960 –> 00:18:06,160
My risk factors would move
from being almost certainly

259
00:18:06,160 –> 00:18:08,520
a cardiac victim at some point

260
00:18:08,520 –> 00:18:10,360
to one in a million.

261
00:18:10,360 –> 00:18:15,400
When you put it as starkly as that,
it’s given me a lot to think about.

262
00:18:31,160 –> 00:18:35,920
Even though the evidence supporting
the benefits of calorie restriction

263
00:18:35,920 –> 00:18:38,800
is getting stronger all the time,

264
00:18:38,800 –> 00:18:42,640
I cannot in all honesty imagine
myself doing what Joe does.

265
00:18:45,080 –> 00:18:48,080
Which creates something of a dilemma.

266
00:18:50,080 –> 00:18:53,480
So, what I really want to do is try

267
00:18:53,480 –> 00:18:57,880
to understand the ways in
which calorie restriction works,

268
00:18:57,880 –> 00:19:01,240
then hopefully I can get
all the delicious benefits

269
00:19:01,240 –> 00:19:03,960
without actually having to do it.

270
00:19:03,960 –> 00:19:05,560
I’m in Los Angeles,

271
00:19:05,560 –> 00:19:09,400
a city that is notoriously
addicted to youth.

272
00:19:09,400 –> 00:19:12,280
In fact, many people here seem to think

273
00:19:12,280 –> 00:19:15,520
that growing old and
wrinkled is optional.

274
00:19:15,520 –> 00:19:19,360
I’m not going to see anyone as
superficial as a plastic surgeon.

275
00:19:19,360 –> 00:19:23,280
I’m here to meet one of the
world’s foremost experts on ageing.

276
00:19:31,640 –> 00:19:34,280
Hi, there. Hey.

277
00:19:34,280 –> 00:19:39,400
Professor Valter Longo studies the
complex mechanisms which control ageing.

278
00:19:41,600 –> 00:19:47,120
He’s honed in on a critical pathway
that links what we eat with how we age.

279
00:19:49,400 –> 00:19:52,360
He’s taking me to see two mice.

280
00:19:52,360 –> 00:19:58,160
They are both the same
age, same species, same sex.

281
00:19:58,160 –> 00:20:02,040
But there’s one significant
difference between them.

282
00:20:02,040 –> 00:20:06,040
The little one is going to
be living an awful lot longer

283
00:20:06,040 –> 00:20:08,120
than the big one.

284
00:20:11,320 –> 00:20:13,560
This little mouse right here

285
00:20:13,560 –> 00:20:17,720
holds the world record for
longevity extension in a mammal.

286
00:20:17,720 –> 00:20:19,920
Oh, right. That is remarkable.

287
00:20:19,920 –> 00:20:22,840
So, how long would these
subspecies of mice last?

288
00:20:22,840 –> 00:20:25,560
The big mouse here, about two years,

289
00:20:25,560 –> 00:20:28,480
and the little mouse,
about a 40% longer lifespan.

290
00:20:28,480 –> 00:20:30,880
Right. They’re very
different, aren’t they?

291
00:20:30,880 –> 00:20:33,120
Whoa! He is trying to bite me.

292
00:20:33,120 –> 00:20:35,600
HE LAUGHS

293
00:20:35,600 –> 00:20:40,120
I could feel that one going through.
Should’ve had the double glove.

294
00:20:40,120 –> 00:20:43,360
I learned the hard way!

295
00:20:43,360 –> 00:20:46,400
The big mouse already has
a 50% chance of being dead.

296
00:20:46,400 –> 00:20:48,560
OK, so he’s doing well to be alive?

297
00:20:48,560 –> 00:20:51,000
He’s lucky to be alive, that’s right.

298
00:20:51,000 –> 00:20:54,680
The small one probably has
another year to go. Oh, right.

299
00:20:54,680 –> 00:20:57,640
The little guy will live on to the
equivalent of what, 120 in human?

300
00:20:57,640 –> 00:21:02,680
Exactly, yeah. Another 30
to 40 years in human years.

301
00:21:02,680 –> 00:21:06,920
Can I pick it up? Go
ahead. By the tail. OK.

302
00:21:10,040 –> 00:21:11,680
The little mouse I’m holding

303
00:21:11,680 –> 00:21:15,160
is actually a man-made creation.

304
00:21:15,160 –> 00:21:18,520
The reason he’s so
small and so long lived

305
00:21:18,520 –> 00:21:21,720
is because he’s been
genetically engineered.

306
00:21:21,720 –> 00:21:26,000
He has incredibly low
levels of a growth hormone

307
00:21:26,000 –> 00:21:29,080
called Insulin-like Growth Factor 1.

308
00:21:29,080 –> 00:21:32,240
And it seems IGF-1 is a key factor

309
00:21:32,240 –> 00:21:35,760
linking calorie
restriction and longevity.

310
00:21:42,080 –> 00:21:46,240
Clues to the link come
from this group of people

311
00:21:46,240 –> 00:21:48,880
who live in a remote region of Ecuador.

312
00:21:50,720 –> 00:21:54,760
They have a very rare
condition called Laron syndrome,

313
00:21:54,760 –> 00:21:58,960
which affects less than
350 people worldwide.

314
00:22:03,360 –> 00:22:05,960
That’s you, is it? It makes you
look like a giant, doesn’t it?

315
00:22:05,960 –> 00:22:08,600
I’m the tall guy there.

316
00:22:08,600 –> 00:22:13,120
The shortest one is just over
three-and-a-half feet tall.

317
00:22:13,120 –> 00:22:15,160
Up to my belly button.
Is that right? Yeah.

318
00:22:15,160 –> 00:22:20,840
‘What interests researchers
like Valter is not their size,

319
00:22:20,840 –> 00:22:25,960
‘but the fact that they seem to be virtually
immune to two of the West’s biggest killers.’

320
00:22:25,960 –> 00:22:27,680
The big findings, of course,

321
00:22:27,680 –> 00:22:31,160
were, they don’t seem to get
either diabetes or cancer.

322
00:22:31,160 –> 00:22:33,720
Do they do all the normal,
sensible things we all do,

323
00:22:33,720 –> 00:22:37,160
like drink, smoke and all that?
Yes, they do the normal, and more,

324
00:22:37,160 –> 00:22:39,760
so they a very unhealthy lifestyle.

325
00:22:39,760 –> 00:22:43,720
Most of them are to some
extent at least overweight.

326
00:22:43,720 –> 00:22:46,520
They seem to really not
watch anything they do.

327
00:22:46,520 –> 00:22:49,640
They smoke or eat very
high calorie diets,

328
00:22:49,640 –> 00:22:53,440
and then they look at me and they say,

329
00:22:53,440 –> 00:22:55,080
“Oh, it doesn’t matter. I’m immune.”

330
00:22:55,080 –> 00:22:59,480
But the incredible thing
is that there’s no evidence

331
00:22:59,480 –> 00:23:02,920
of a single one of them
ever dying of cancer,

332
00:23:02,920 –> 00:23:06,640
yet their normal-height relatives
get cancer like everybody else.

333
00:23:08,000 –> 00:23:13,000
People with Laron syndrome have
a mutation which makes them small,

334
00:23:13,000 –> 00:23:17,280
but which also seems to protect
them against all these diseases.

335
00:23:19,320 –> 00:23:21,440
It’s incredible working with them.

336
00:23:23,640 –> 00:23:29,120
It’s a great group, and of course for
us is a group that in one mutation,

337
00:23:29,120 –> 00:23:33,480
can tell us about diabetes, cancer,
cardiovascular diseases and ageing.

338
00:23:37,240 –> 00:23:40,440
The Ecuadorian villagers
and the long-lived mice

339
00:23:40,440 –> 00:23:42,720
have something in common.

340
00:23:42,720 –> 00:23:46,240
Their bodies produce
exceptionally low levels

341
00:23:46,240 –> 00:23:48,080
of the growth hormone IGF-1.

342
00:23:50,520 –> 00:23:56,440
This discovery helped Valter piece
together role that IGF-1 plays

343
00:23:56,440 –> 00:23:59,400
in the complicated business of ageing.

344
00:23:59,400 –> 00:24:02,800
Our bodies are
normally in go-go mode –

345
00:24:02,800 –> 00:24:07,560
cells constantly driven
to divide by IGF-1.

346
00:24:07,560 –> 00:24:10,400
But when IGF-1 levels drop,

347
00:24:10,400 –> 00:24:14,080
our cells shift into a
completely different mode.

348
00:24:14,080 –> 00:24:17,480
The body slows production of new cells

349
00:24:17,480 –> 00:24:20,800
and starts repairing
existing ones instead.

350
00:24:20,800 –> 00:24:25,520
DNA damage is more likely to get fixed.

351
00:24:25,520 –> 00:24:29,480
And that’s why the mice AND
the villagers are protected

352
00:24:29,480 –> 00:24:31,600
from age-related diseases.

353
00:24:40,480 –> 00:24:44,160
But what’s the link to
calorie restriction in humans?

354
00:24:44,160 –> 00:24:49,960
Valter has lined up a very
simple, very Californian analogy.

355
00:24:51,440 –> 00:24:55,040
It turns out there is
something in the food we eat

356
00:24:55,040 –> 00:24:59,280
that affects how much
IGF-1 our bodies produce.

357
00:24:59,280 –> 00:25:01,880
That something is protein.

358
00:25:02,920 –> 00:25:07,800
When we eat a lot of protein, our
cells get locked in go-go mode.

359
00:25:07,800 –> 00:25:10,920
So it’s basically like slamming
your foot on the accelerator,

360
00:25:10,920 –> 00:25:13,320
saying, “Go! Go! Go!”
Is that right? Exactly.

361
00:25:13,320 –> 00:25:17,000
It’s pushing the cell to burn fuel.

362
00:25:17,000 –> 00:25:19,000
In go-go mode,

363
00:25:19,000 –> 00:25:22,800
the body is more susceptible
to some cancers and diabetes,

364
00:25:22,800 –> 00:25:25,120
because your cells are growing too fast

365
00:25:25,120 –> 00:25:27,440
for damage to be efficiently repaired.

366
00:25:27,440 –> 00:25:30,760
So it’s like driving
your car all the time

367
00:25:30,760 –> 00:25:32,560
and never taking it to the mechanic.

368
00:25:32,560 –> 00:25:36,160
Right, so that’s the key,
basically, is to somehow find a way

369
00:25:36,160 –> 00:25:39,120
to switch your body from
going, “Broom, broom, broom,”

370
00:25:39,120 –> 00:25:44,080
into a sort of repair mode, “Look
after me, make my DNA better.” Exactly.

371
00:25:46,480 –> 00:25:49,400
So, how do you reduce your IGF-1?

372
00:25:50,520 –> 00:25:54,560
Well, studies on calorie restrictors
suggests that eating less helps,

373
00:25:54,560 –> 00:25:55,960
but it’s not enough.

374
00:25:57,040 –> 00:26:01,280
As well as cutting calories, you
have to cut your protein intake.

375
00:26:01,280 –> 00:26:05,640
Not entirely
– that would be a very bad idea.

376
00:26:05,640 –> 00:26:08,520
It’s about sticking to
recommended guidelines,

377
00:26:08,520 –> 00:26:11,800
something most of us fail to do.

378
00:26:11,800 –> 00:26:15,840
And you don’t have to be
a CRonie to lower IGF-1.

379
00:26:15,840 –> 00:26:18,840
There is another way
– fasting.

380
00:26:18,840 –> 00:26:25,560
In fasting, there is a much more
dramatic and much quicker response,

381
00:26:25,560 –> 00:26:30,880
and so, within 24 hours, you
decrease your glucose level

382
00:26:30,880 –> 00:26:35,480
and you decrease your main
growth factor, which is IGF-1.

383
00:26:38,360 –> 00:26:42,960
I do find it hard to believe
that just a few days of fasting

384
00:26:42,960 –> 00:26:47,480
is going to be enough to jolt my
body into a more healthy state.

385
00:26:49,200 –> 00:26:53,720
But I’m certainly intrigued,
and I want to find out more.

386
00:26:53,720 –> 00:26:56,360
So I’ve had my IGF
measured back in London,

387
00:26:56,360 –> 00:26:59,200
and they tell me that it’s 28.

388
00:26:59,200 –> 00:27:01,200
Is that good? Bad?

389
00:27:01,200 –> 00:27:05,160
That’s not very bad,
but that’s high enough

390
00:27:05,160 –> 00:27:09,160
that, based on a number of
studies, including our own,

391
00:27:09,160 –> 00:27:14,480
it puts you in a higher risk category
for several different cancers,

392
00:27:14,480 –> 00:27:16,840
including prostate cancer.

393
00:27:16,840 –> 00:27:21,320
Valter believes I should start to
see some pretty impressive results

394
00:27:21,320 –> 00:27:25,400
after just three days and
four nights of fasting.

395
00:27:25,400 –> 00:27:27,680
But it’s a daunting prospect.

396
00:27:29,040 –> 00:27:32,080
I think fasting’s quite tough,
isn’t it? Have you done it yourself?

397
00:27:32,080 –> 00:27:34,280
I’ve done it myself, yes,

398
00:27:34,280 –> 00:27:38,280
I’ve fasted for four days several times

399
00:27:38,280 –> 00:27:39,920
and to me it was very tough, yeah.

400
00:27:39,920 –> 00:27:43,360
And still, if I look
ahead at doing fasting,

401
00:27:43,360 –> 00:27:46,800
I see it as a tough four
days, I’m not looking forward.

402
00:27:46,800 –> 00:27:48,920
Some people do, but I don’t.

403
00:27:48,920 –> 00:27:52,600
I’m Italian, so I look forward
to eating well, you know.

404
00:27:52,600 –> 00:27:55,200
I’ll bear that image in mind. Yeah.

405
00:27:55,200 –> 00:27:58,240
The greedy Italian stopping eating
when I’m feeling weak about it.

406
00:27:58,240 –> 00:27:59,440
There you go. Thank you.

407
00:28:08,520 –> 00:28:11,480
Prolonged fasting can be dangerous

408
00:28:11,480 –> 00:28:15,080
and Valter thinks it should only be
undertaken by people in good health

409
00:28:15,080 –> 00:28:18,240
and preferably, under close supervision.

410
00:28:18,240 –> 00:28:20,120
So he will be keeping an eye on me.

411
00:28:21,760 –> 00:28:26,360
OK, I’ve decided I’m
going to try this fast,

412
00:28:26,360 –> 00:28:29,280
which is going to be a
three-and-a-half-day fast

413
00:28:29,280 –> 00:28:35,120
and all I’m going to have
is lots of water, black tea

414
00:28:35,120 –> 00:28:39,520
and one 50-calorie
Cup-a-Soup a day.

415
00:28:39,520 –> 00:28:44,680
Now… Oh, God, I have never done
anything quite like this before,

416
00:28:44,680 –> 00:28:46,920
so I imagine it’s going
to be really tough.

417
00:28:46,920 –> 00:28:49,000
But I’m interested.

418
00:28:49,000 –> 00:28:52,640
I’m also, I must admit,
quite concerned about some of

419
00:28:52,640 –> 00:28:55,880
the rather bad news, health
news I’ve been getting recently,

420
00:28:55,880 –> 00:29:01,960
so, um…it’ll be a challenge,
but I’m sure I’ll manage it.

421
00:29:03,360 –> 00:29:05,720
Reasonably sure.

422
00:29:08,520 –> 00:29:10,920
And so, my fast begins.

423
00:29:17,480 –> 00:29:22,600
Right. It is now 10.30
at night and I am hungry.

424
00:29:22,600 –> 00:29:29,120
It has been, oh, just about 25
hours since I last ate a meal

425
00:29:29,120 –> 00:29:35,360
and the prospect of going to bed
while hungry is not a great one.

426
00:29:36,960 –> 00:29:39,680
I think it’s getting to me,
because last night I had a dream

427
00:29:39,680 –> 00:29:44,080
and I dreamt I ate a sandwich and
then I felt fantastically guilty.

428
00:29:44,080 –> 00:29:47,960
So vivid, I had a look round to see if there
were any crumbs in the bed, but there weren’t.

429
00:29:47,960 –> 00:29:50,440
I guess time to go to work.

430
00:29:53,480 –> 00:29:56,240
Simple dietary intervention

431
00:29:56,240 –> 00:29:59,120
can really change how
the human body works.

432
00:29:59,120 –> 00:30:01,600
It puts you in a higher risk category.

433
00:30:04,440 –> 00:30:08,920
Just as Valter warned me,
the first day was tough.

434
00:30:08,920 –> 00:30:11,520
Not really because I was that hungry,

435
00:30:11,520 –> 00:30:15,880
but simply because I had never
done anything like this before.

436
00:30:15,880 –> 00:30:18,880
It was fear of the unknown.

437
00:30:18,880 –> 00:30:22,720
My nightfall, I’m beginning to
think this is a very bad idea…

438
00:30:25,400 –> 00:30:28,280
..particularly when I
had dinner with the crew.

439
00:30:33,600 –> 00:30:36,120
Or rather, when they had dinner.

440
00:30:38,160 –> 00:30:41,720
So, yeah, here I am in a
nice old Korean restaurant

441
00:30:41,720 –> 00:30:45,200
with the rest of the crew.

442
00:30:45,200 –> 00:30:48,240
And they are currently digging in…

443
00:30:48,240 –> 00:30:50,440
Enjoying it, guys?

444
00:30:50,440 –> 00:30:51,680
Beautiful. Yes.

445
00:30:51,680 –> 00:30:56,560
It’s a good smell. I really,
really wouldn’t mind a little bite.

446
00:30:59,480 –> 00:31:02,080
I do feel very hungry.

447
00:31:03,760 –> 00:31:08,720
Fortunately, my dinner is
waiting for me in my hotel room.

448
00:31:13,080 –> 00:31:15,880
I had to leave, I couldn’t
bear it any longer.

449
00:31:22,360 –> 00:31:26,440
HE SIGHS My delicious miso soup here.

450
00:31:26,440 –> 00:31:29,280
Give a bit of a stir with the hotel pen,

451
00:31:29,280 –> 00:31:31,680
because there’s no other cutlery around.

452
00:31:33,240 –> 00:31:34,960
Mmm!

453
00:31:36,280 –> 00:31:38,960
Health. 25 calories’ worth.

454
00:31:38,960 –> 00:31:40,960
And I’m looking forward to it.

455
00:31:44,400 –> 00:31:46,440
Ah!

456
00:31:48,160 –> 00:31:52,160
OK, final full day of fasting.

457
00:31:52,160 –> 00:31:54,440
Delicious breakfast here, black tea.

458
00:31:54,440 –> 00:31:58,200
I’m feeling a bit light-headed
but otherwise actually all right.

459
00:31:58,200 –> 00:32:00,160
So, just 24 hours to go

460
00:32:00,160 –> 00:32:03,440
and now I’m pretty confident
I’ll be able to do it.

461
00:32:11,760 –> 00:32:15,120
I’ve learnt that hunger
does not build and build,

462
00:32:15,120 –> 00:32:16,880
but comes in waves that pass.

463
00:32:18,200 –> 00:32:21,760
By now, I have depleted
my body’s store of glucose

464
00:32:21,760 –> 00:32:26,200
and will have switched to
burning fat for fuel instead.

465
00:32:26,200 –> 00:32:27,960
And if Valter is right,

466
00:32:27,960 –> 00:32:33,000
my liver should also have
stopped producing so much IGF-1,

467
00:32:33,000 –> 00:32:36,040
putting my cells into repair mode.

468
00:32:39,680 –> 00:32:44,600
Finally, it’s 7am, day four,
I’m getting my blood test done.

469
00:32:45,600 –> 00:32:49,440
So, after this, I can go and
have breakfast? Absolutely.

470
00:32:49,440 –> 00:32:51,560
The first food for
three-and-a-half days,

471
00:32:51,560 –> 00:32:55,760
the first food for 86 hours.
Well, who’s counting(?)

472
00:32:55,760 –> 00:32:58,640
I’m just hoping that this
is going to show some change,

473
00:32:58,640 –> 00:33:02,120
particularly in my IGF, cos if I
have spent the last three-and-a-half

474
00:33:02,120 –> 00:33:05,440
to four days not eating and the
results have been absolutely zero,

475
00:33:05,440 –> 00:33:07,760
that would be very, very depressing.

476
00:33:09,800 –> 00:33:13,360
The fast is over.

477
00:33:13,360 –> 00:33:16,720
Mmm. Ah! That is very…

478
00:33:16,720 –> 00:33:19,400
I can just sort of begin
to feel the empty spaces.

479
00:33:19,400 –> 00:33:23,360
I wasn’t actually terrible hungry
when I woke up this morning, but…

480
00:33:25,840 –> 00:33:28,960
..when I start eating this, I
realise what it is I was missing.

481
00:33:33,280 –> 00:33:37,800
Later that afternoon, I meet
up with Valter to find out

482
00:33:37,800 –> 00:33:39,600
if it’s all been worthwhile.

483
00:33:41,120 –> 00:33:44,960
I broke my fast this morning, I
had some porridge and some bacon

484
00:33:44,960 –> 00:33:47,600
and I feel better. Oh, good, good.

485
00:33:47,600 –> 00:33:50,960
I’ll feel even more terrific
if these results are any good.

486
00:33:50,960 –> 00:33:53,640
Yeah, let’s take a look at them.

487
00:33:53,640 –> 00:33:58,240
So, your insulin-like growth factor
one, IGF-1, this is the normal value.

488
00:33:58,240 –> 00:34:01,640
Wow. The bad news, you’re almost
at the top of the normal range.

489
00:34:01,640 –> 00:34:03,760
For American standards,
you’re doing good.

490
00:34:03,760 –> 00:34:07,440
But not good full-stop, but not
bad. I’m an average American, am I?

491
00:34:07,440 –> 00:34:10,520
That’s right, yeah.
And the good news is,

492
00:34:10,520 –> 00:34:13,880
with your fasting diet, you
dropped to almost half. Wow.

493
00:34:13,880 –> 00:34:16,480
That’s big, isn’t it?
Yeah. That’s a big drop.

494
00:34:16,480 –> 00:34:18,960
It’s a very dramatic drop,
so you respond very well.

495
00:34:18,960 –> 00:34:20,960
I have to say, it was fascinating.

496
00:34:20,960 –> 00:34:25,400
Seeing that is very,
very… um, surprising.

497
00:34:25,400 –> 00:34:28,320
‘Surprising
– and a huge relief.

498
00:34:28,320 –> 00:34:32,360
‘Halving my IGF-1 should cut
my risk of certain cancers,

499
00:34:32,360 –> 00:34:34,920
‘like prostate cancer,
which my father had.

500
00:34:34,920 –> 00:34:37,880
‘My blood sugar has also
dropped to healthy levels,

501
00:34:37,880 –> 00:34:39,760
‘which I’m really pleased about.’

502
00:34:40,960 –> 00:34:47,840
I challenge you in four days to
get more extreme metabolic changes

503
00:34:47,840 –> 00:34:50,160
than these with anything you want.

504
00:34:50,160 –> 00:34:52,800
I think this is quite
extreme enough! Yeah.

505
00:34:52,800 –> 00:34:55,800
Yeah, but, you know, if you can
find something else that you can do,

506
00:34:55,800 –> 00:34:58,280
that it doesn’t hurt
you, that benefits you

507
00:34:58,280 –> 00:35:01,800
and that causes these
changes, I’d like to know. OK.

508
00:35:05,520 –> 00:35:08,280
But Valter says, unless I switch

509
00:35:08,280 –> 00:35:11,480
to a lower protein,
more plant-based diet,

510
00:35:11,480 –> 00:35:14,080
the effects won’t last.

511
00:35:16,040 –> 00:35:18,720
I’ll also need to fast
once every couple of months,

512
00:35:18,720 –> 00:35:21,920
to maintain the benefits.

513
00:35:21,920 –> 00:35:25,560
Can I really see myself doing that?

514
00:35:25,560 –> 00:35:27,720
You have to make a
decision now, in your case,

515
00:35:27,720 –> 00:35:29,240
what do you want to do, you know?

516
00:35:29,240 –> 00:35:32,240
And there is a lot of drugs
that you could be taking,

517
00:35:32,240 –> 00:35:34,000
and is that what you want to do?

518
00:35:34,000 –> 00:35:39,200
And if you do so, in a few
years, or in a number of years,

519
00:35:39,200 –> 00:35:43,080
you’re going to be the
typical 65-year-old in Europe

520
00:35:43,080 –> 00:35:47,120
that takes eight drugs a
day, and so that’s the option.

521
00:35:47,120 –> 00:35:50,200
MICHAEL LAUGHS And that’s your call.

522
00:35:50,200 –> 00:35:54,320
Thank you, OK! That’s
quite an interesting choice!

523
00:36:01,440 –> 00:36:04,360
That is really, really impressive,

524
00:36:04,360 –> 00:36:06,400
that in just
three-and-a-half days,

525
00:36:06,400 –> 00:36:09,160
if this data is right, and
the animal data is right,

526
00:36:09,160 –> 00:36:12,160
I have massively decreased my risk

527
00:36:12,160 –> 00:36:16,280
of a whole range of
age-related diseases.

528
00:36:16,280 –> 00:36:19,760
The big question in my
mind at the moment is,

529
00:36:19,760 –> 00:36:22,960
can I do fasting once a month,

530
00:36:22,960 –> 00:36:25,920
for however long it takes?

531
00:36:25,920 –> 00:36:28,200
Or is there a better
way, a different way,

532
00:36:28,200 –> 00:36:30,200
a more manageable way out there,

533
00:36:30,200 –> 00:36:33,640
that can do much of what this does,

534
00:36:33,640 –> 00:36:37,360
but perhaps with a little less pain?

535
00:36:37,360 –> 00:36:40,600
What I’ve discovered
about myself is that

536
00:36:40,600 –> 00:36:46,040
the biggest problem with
prolonged fasting is me.

537
00:36:48,480 –> 00:36:51,520
VALTER: ‘You have to
make a decision now.

538
00:36:51,520 –> 00:36:52,880
‘Fasting is tough.’

539
00:36:55,160 –> 00:36:58,360
Despite knowing all the
wonderful benefits…

540
00:37:00,480 –> 00:37:03,000
..I just can’t bring myself to do it.

541
00:37:15,680 –> 00:37:18,920
But the great thing about science

542
00:37:18,920 –> 00:37:22,720
is there is always
someone doing further work,

543
00:37:22,720 –> 00:37:25,280
building on what others have achieved,

544
00:37:25,280 –> 00:37:28,720
which is why I’m here in Chicago.

545
00:37:28,720 –> 00:37:33,320
Here, they are doing studies not
just on mice, but also on humans.

546
00:37:37,200 –> 00:37:39,920
And they seem to have found a way

547
00:37:39,920 –> 00:37:43,520
of making fasting a lot more palatable.

548
00:37:43,520 –> 00:37:48,440
I’m here to meet Dr Krista Varady,

549
00:37:48,440 –> 00:37:52,600
who has been researching
something that sounds easier.

550
00:37:52,600 –> 00:37:54,400
Alternate day fasting.

551
00:37:54,400 –> 00:37:57,040
Hello! Hello there! Hi!

552
00:37:57,040 –> 00:38:00,560
Very nice to meet you. Nice to
meet you! My name’s Krista Varady.

553
00:38:00,560 –> 00:38:02,360
Hello! So what have you got here, then?

554
00:38:02,360 –> 00:38:04,400
So this is some of the
components that we’d use

555
00:38:04,400 –> 00:38:08,040
in an alternate day fasting diet.

556
00:38:08,040 –> 00:38:11,560
It basically involves a day of
pretty heavy calorie restriction.

557
00:38:11,560 –> 00:38:13,720
For women, about 400
to 500 calories a day,

558
00:38:13,720 –> 00:38:16,280
and for men, about 500
to 600 calories a day,

559
00:38:16,280 –> 00:38:18,760
and that’s actually just as
one meal, around lunchtime.

560
00:38:18,760 –> 00:38:22,040
We call that the fast day.

561
00:38:22,040 –> 00:38:24,560
So the fast day isn’t
about total abstinence.

562
00:38:24,560 –> 00:38:27,640
It’s about meals that look like this.

563
00:38:27,640 –> 00:38:31,480
What’s great about alternate day fasting

564
00:38:31,480 –> 00:38:33,520
is what happens on the alternate days.

565
00:38:33,520 –> 00:38:36,920
And then that’s alternated with
something we call the feed day,

566
00:38:36,920 –> 00:38:40,560
which is where you can eat whatever
you want. Absolutely whatever you want.

567
00:38:40,560 –> 00:38:44,680
So here’s the pattern
of alternate day fasting.

568
00:38:44,680 –> 00:38:46,880
Fast day.

569
00:38:46,880 –> 00:38:47,960
Feed day.

570
00:38:47,960 –> 00:38:49,880
Fast day.

571
00:38:49,880 –> 00:38:51,320
Feed day.

572
00:38:51,320 –> 00:38:56,320
It certainly sounds easier
than either prolonged fasting

573
00:38:56,320 –> 00:38:59,120
or the daily calorie
restriction I looked at earlier.

574
00:38:59,120 –> 00:39:00,680
But is it as effective?

575
00:39:00,680 –> 00:39:04,800
Well, Krista’s currently doing
a trial with overweight subjects

576
00:39:04,800 –> 00:39:08,280
which suggests it might be.

577
00:39:08,280 –> 00:39:10,840
What we saw was that the
alternate day fasting group

578
00:39:10,840 –> 00:39:12,960
actually lost a bit more weight,

579
00:39:12,960 –> 00:39:16,360
so about 5lb more after
the 6-month period.

580
00:39:16,360 –> 00:39:21,480
And they actually saw some pretty
nice decreases in LDL cholesterol,

581
00:39:21,480 –> 00:39:23,240
as well as triglycerides.

582
00:39:23,240 –> 00:39:26,160
So LDL cholesterol is
the bad cholesterol,

583
00:39:26,160 –> 00:39:29,440
and triglycerides
– basically higher amounts of that

584
00:39:29,440 –> 00:39:32,720
can lead to heart disease
and age-related disease.

585
00:39:32,720 –> 00:39:36,280
We also see really nice
decreases in blood pressure

586
00:39:36,280 –> 00:39:37,840
over the course of the trials.

587
00:39:37,840 –> 00:39:42,040
So, again, another key
heart disease risk factor.

588
00:39:49,400 –> 00:39:51,800
‘In addition to so far
rather limited human trials,

589
00:39:51,800 –> 00:39:55,160
‘there’s lots of good
evidence from animal studies

590
00:39:55,160 –> 00:39:58,600
‘that alternate day fasting,
ADF, is safe and effective.

591
00:40:00,320 –> 00:40:02,880
‘I’m convinced enough to try it.

592
00:40:02,880 –> 00:40:05,400
‘Yesterday I fasted.

593
00:40:05,400 –> 00:40:07,360
‘Today I feed.’

594
00:40:07,360 –> 00:40:11,000
So hopefully, we will make
it back…easily enough.

595
00:40:11,000 –> 00:40:15,040
Ooh, magical mystery tour!
I like that! Yeah, yeah!

596
00:40:15,040 –> 00:40:18,160
MUSIC: ‘Johnny B Goode’ by Chuck Berry

597
00:40:27,120 –> 00:40:29,520
BUZZER Hi, thanks for stopping.

598
00:40:29,520 –> 00:40:31,360
May I take your order, please?

599
00:40:31,360 –> 00:40:35,520
♪ Deep down in Louisiana
Close to New Orleans

600
00:40:35,520 –> 00:40:37,520
♪ Way back up in the
woods among the evergreens

601
00:40:37,520 –> 00:40:40,360
♪ There stood a log cabin
made of earth and wood

602
00:40:40,360 –> 00:40:42,800
♪ Where lived a country
boy named Johnny B Goode. ♪

603
00:40:42,800 –> 00:40:44,160
A very good choice!

604
00:40:44,160 –> 00:40:47,040
I particularly like the green
stuff that’s oozing out of it.

605
00:40:47,040 –> 00:40:48,600
So, I must admit,

606
00:40:48,600 –> 00:40:52,440
I am surprised to be here.

607
00:40:52,440 –> 00:40:55,760
I kind of imagined you’d be
sticking on a sort of, um,

608
00:40:55,760 –> 00:40:58,080
you know, a veggie diet
or something like that.

609
00:40:58,080 –> 00:41:00,760
Or, yeah, a lot of salads
or something on the feed day?

610
00:41:00,760 –> 00:41:04,920
No, actually as long as you stick
to the calorie goals on the fast day,

611
00:41:04,920 –> 00:41:09,400
you can literally eat whatever
you like on the feed day.

612
00:41:09,400 –> 00:41:13,680
‘One of Krista’s most recent
studies compared two groups on ADF,

613
00:41:13,680 –> 00:41:16,560
‘one eating high fat, the other low fat,

614
00:41:16,560 –> 00:41:18,960
‘on their feed days.’

615
00:41:18,960 –> 00:41:21,120
I’m concerned about my blood glucose,

616
00:41:21,120 –> 00:41:23,000
I’m concerned about my cholesterol,

617
00:41:23,000 –> 00:41:25,440
I’m concerned about a
load of stuff. Yeah, yeah.

618
00:41:25,440 –> 00:41:29,240
Are those not, sort of, made
worse by eating high fat?

619
00:41:29,240 –> 00:41:31,320
That’s actually what
we thought would happen.

620
00:41:31,320 –> 00:41:32,640
And then, surprisingly,

621
00:41:32,640 –> 00:41:35,000
we saw the same decreases
in LDL cholesterol,

622
00:41:35,000 –> 00:41:36,880
so that’s the bad cholesterol,

623
00:41:36,880 –> 00:41:38,600
and in triglycerides,

624
00:41:38,600 –> 00:41:40,800
and also in blood pressure.

625
00:41:40,800 –> 00:41:43,000
So in terms of
cardiovascular disease risk,

626
00:41:43,000 –> 00:41:45,600
it didn’t matter if you were
eating a high-fat or low-fat diet.

627
00:41:45,600 –> 00:41:50,200
Another big surprise was
that, after a day of fasting,

628
00:41:50,200 –> 00:41:54,280
people rarely gorge
themselves on their feed days.

629
00:41:57,680 –> 00:42:01,320
So when we ask someone to consume 25%
of their energy needs on the fast day,

630
00:42:01,320 –> 00:42:03,880
I just thought that when I
started running these trials,

631
00:42:03,880 –> 00:42:05,920
that people would eat 175% the next day.

632
00:42:05,920 –> 00:42:09,120
But right from the
get-go, no matter what,

633
00:42:09,120 –> 00:42:13,840
people just can’t eat
that 175% the next day.

634
00:42:13,840 –> 00:42:16,320
Most people eat around the 110%.

635
00:42:16,320 –> 00:42:18,880
So just slightly over what
they usually eat, actually.

636
00:42:18,880 –> 00:42:21,320
You appear to be slowing
down the ageing process,

637
00:42:21,320 –> 00:42:23,000
or the diseases associated with it.

638
00:42:23,000 –> 00:42:25,600
You’re cutting the risks
of the diseases associated,

639
00:42:25,600 –> 00:42:28,120
which is quite a profound
thing to do. Yeah, absolutely.

640
00:42:33,640 –> 00:42:37,200
Krista’s research is
still in the early stages.

641
00:42:37,200 –> 00:42:40,360
But from what I’ve seen and experienced,

642
00:42:40,360 –> 00:42:42,520
I am now starting to be won over

643
00:42:42,520 –> 00:42:45,360
by the idea that a simple pattern

644
00:42:45,360 –> 00:42:49,040
of feast and fast can be powerful.

645
00:42:49,040 –> 00:42:54,000
It seems to have an impact which
goes beyond simply eating less.

646
00:42:54,000 –> 00:42:57,240
And I think it could
work for someone like me.

647
00:43:03,080 –> 00:43:05,920
My final stop is Baltimore.

648
00:43:05,920 –> 00:43:09,520
I’m here because I need
a final bit of motivation.

649
00:43:12,560 –> 00:43:17,240
There’s one aspect of ageing I
find more terrifying than any other.

650
00:43:17,240 –> 00:43:21,320
The effects of ageing on my brain.

651
00:43:24,280 –> 00:43:27,440
I’m trying to catch up
with Professor Mark Mattson.

652
00:43:27,440 –> 00:43:31,840
Mark is a leading expert
on the ageing brain.

653
00:43:31,840 –> 00:43:34,960
His research suggests that fasting

654
00:43:34,960 –> 00:43:37,800
may help delay the onset of diseases

655
00:43:37,800 –> 00:43:40,520
like Alzheimer’s,
dementia, and memory loss.

656
00:43:40,520 –> 00:43:41,680
Very good! How you doing?

657
00:43:41,680 –> 00:43:44,560
Hi there! Michael Mosley. Mark Mattson.

658
00:43:44,560 –> 00:43:47,520
You work here?! Work here? No!

659
00:43:47,520 –> 00:43:50,840
Nor do I work out
here! MICHAEL CHUCKLES.

660
00:43:50,840 –> 00:43:54,800
OK, Michael. We need
to put some booties on!

661
00:43:56,520 –> 00:43:59,880
We’re heading down into the basement

662
00:43:59,880 –> 00:44:03,080
of the National Institute on Ageing.

663
00:44:03,080 –> 00:44:04,280
OK? Yeah.

664
00:44:04,280 –> 00:44:06,000
Hidden away down here,

665
00:44:06,000 –> 00:44:09,720
there’s a special mouse
he’s keen to show me.

666
00:44:17,680 –> 00:44:20,400
This mouse is exploring a maze.

667
00:44:22,800 –> 00:44:25,680
It’s a memory test, designed
to see how well he remembers

668
00:44:25,680 –> 00:44:28,840
where he has found food before.

669
00:44:28,840 –> 00:44:32,000
So the food is actually in
there, is it? The food’s in here.

670
00:44:32,000 –> 00:44:35,920
The mice they study are destined
to develop Alzheimer’s disease.

671
00:44:38,440 –> 00:44:41,560
Normally, they succumb within
a relatively short time,

672
00:44:41,560 –> 00:44:44,360
but when these mice are put on a diet

673
00:44:44,360 –> 00:44:47,160
of feast days and fast days,

674
00:44:47,160 –> 00:44:50,120
what Mark calls “intermittent
energy restriction”,

675
00:44:50,120 –> 00:44:51,840
the results are incredible.

676
00:44:51,840 –> 00:44:55,680
..So that the animals on
intermittent energy restriction,

677
00:44:55,680 –> 00:44:58,240
they’ll live much longer with normal,

678
00:44:58,240 –> 00:44:59,880
at least, as best we can test,

679
00:44:59,880 –> 00:45:03,560
normal learning and memory,
before they start having problems.

680
00:45:03,560 –> 00:45:05,280
Significantly longer?

681
00:45:05,280 –> 00:45:07,480
Yeah, highly significantly.

682
00:45:07,480 –> 00:45:10,600
We found in one study,
six months to a year.

683
00:45:10,600 –> 00:45:14,280
That’s the equivalent in a
human of the difference between

684
00:45:14,280 –> 00:45:17,280
developing signs of Alzheimer’s
at say, the age of 50,

685
00:45:17,280 –> 00:45:20,760
and the age of 80? Something
like that? Is that right? Yeah.

686
00:45:20,760 –> 00:45:24,160
‘On the other hand, when the
mice eat a fast-food diet,

687
00:45:24,160 –> 00:45:27,640
‘they go downhill much earlier.’

688
00:45:27,640 –> 00:45:30,920
We give them… Lots of sugary
drinks? A high-fat diet, exactly.

689
00:45:30,920 –> 00:45:32,880
And we put fructose in
their drinking water,

690
00:45:32,880 –> 00:45:35,520
and that has a dramatic effect.

691
00:45:35,520 –> 00:45:37,920
The animals will have an earlier onset

692
00:45:37,920 –> 00:45:40,280
of the learning and memory problems.

693
00:45:40,280 –> 00:45:41,720
How much sooner?

694
00:45:41,720 –> 00:45:44,880
Um, three to four months sooner. Wow.

695
00:45:44,880 –> 00:45:48,760
So that is the equivalent of
them developing Alzheimer’s

696
00:45:48,760 –> 00:45:51,360
in their 30s or maybe early 40s? Right.

697
00:45:51,360 –> 00:45:55,120
So far, they’ve only
done studies in mice,

698
00:45:55,120 –> 00:45:58,040
but they’re about to
carry out human trials.

699
00:45:58,040 –> 00:46:00,400
How good if the evidence
that if someone like me

700
00:46:00,400 –> 00:46:02,520
were to start on intermittent fasting,

701
00:46:02,520 –> 00:46:05,520
it would cut my risk of
brain disease, broadly?

702
00:46:07,640 –> 00:46:10,000
I think, from the human standpoint,

703
00:46:10,000 –> 00:46:16,000
if we go on a scale from
poor to good to very good

704
00:46:16,000 –> 00:46:18,080
to excellent to outstanding,

705
00:46:18,080 –> 00:46:20,400
it’s in the very good
to excellent range.

706
00:46:21,760 –> 00:46:24,720
That’s the way I would categorise it.

707
00:46:29,560 –> 00:46:31,320
So, what’s going on?

708
00:46:33,440 –> 00:46:36,120
Well, when they examined the
brains of the fasting mice,

709
00:46:36,120 –> 00:46:39,440
they found something extraordinary.

710
00:46:39,440 –> 00:46:44,920
These green objects
are newborn brain cells.

711
00:46:44,920 –> 00:46:47,080
These three here are brand new?

712
00:46:47,080 –> 00:46:53,600
Sporadic bouts of hunger actually
trigger new neurons to grow.

713
00:46:53,600 –> 00:46:57,160
Why should a brain start to generate

714
00:46:57,160 –> 00:47:00,000
new nerve cells when
you stop feeding it?

715
00:47:00,000 –> 00:47:03,240
If you think about this in
evolutionary terms, it makes sense

716
00:47:03,240 –> 00:47:09,040
if you’re hungry, you’d better
increase your cognitive ability.

717
00:47:09,040 –> 00:47:11,280
That will give you a survival advantage,

718
00:47:11,280 –> 00:47:15,000
if you can remember where the
location of the food is and so on.

719
00:47:17,040 –> 00:47:22,760
It seems that fasting stresses your grey matter
the way that exercise stresses your muscles.

720
00:47:25,480 –> 00:47:30,160
So hunger really does make
you sharper? Yes. We think so.

721
00:47:34,080 –> 00:47:39,280
Mark’s research is starting to
point towards a simple conclusion.

722
00:47:39,280 –> 00:47:43,600
Alternate day fasting has
better effects on the brain

723
00:47:43,600 –> 00:47:47,480
than does a lower amount of
daily calorie restriction.

724
00:47:47,480 –> 00:47:53,280
It’s true of mice, but he needs to do
proper human trials to prove it’s true in us.

725
00:47:57,840 –> 00:48:02,000
I’ve come to the end of my search to
find out how to eat, fast and live longer.

726
00:48:03,200 –> 00:48:07,600
The official advice is, eat
at least 2,000 calories a day,

727
00:48:07,600 –> 00:48:11,640
and if you really want to fast,
even on an intermittent basis,

728
00:48:11,640 –> 00:48:15,920
see your doctor first, because
there are people it could harm,

729
00:48:15,920 –> 00:48:19,560
such as pregnant women or those
who are already underweight.

730
00:48:21,200 –> 00:48:25,960
I’m going to be cautious, and have decided
to go with a pattern that Mark recommended.

731
00:48:25,960 –> 00:48:31,680
Not alternate day fasting, but
a less extreme five/two diet –

732
00:48:31,680 –> 00:48:37,080
five days’ normal eating, followed
by two days’ fasting, each week.

733
00:48:38,360 –> 00:48:43,720
It’s my last day in the States, and
it has been absolutely eye opening.

734
00:48:43,720 –> 00:48:48,480
I had no idea at all that there
was so much research going on

735
00:48:48,480 –> 00:48:54,200
into fasting, calorie restriction in all
its forms, and sort of anti-ageing research.

736
00:48:55,200 –> 00:48:59,960
I’ve decided now that I am definitely
going to try the five/two diet,

737
00:48:59,960 –> 00:49:05,200
that’s five days’ normal eating,
then two days of 600 calories a day.

738
00:49:05,200 –> 00:49:07,760
I really, really hope
it makes a difference,

739
00:49:07,760 –> 00:49:11,360
because I’m conscious now that
I am really at the foothills

740
00:49:11,360 –> 00:49:14,720
of what could be quite
a steep advance into age,

741
00:49:14,720 –> 00:49:19,560
and if there is something that could
slow that ageing process down and give me

742
00:49:19,560 –> 00:49:25,360
more years of healthy living,
then I would really embrace that.

743
00:49:31,000 –> 00:49:35,280
I’m heading home to the UK.

744
00:49:35,280 –> 00:49:40,560
I’ve decided to give myself five
weeks to get used to my new diet,

745
00:49:40,560 –> 00:49:43,760
and see if I get results.

746
00:49:49,760 –> 00:49:52,520
This is going to be
one of my fasting days,

747
00:49:52,520 –> 00:49:55,240
and I’ve decided I’m going to
eat breakfast as my main meal.

748
00:49:55,240 –> 00:49:59,440
Mark Mattson told me he
doesn’t think it matters

749
00:49:59,440 –> 00:50:01,760
when you eat your
calories on a fast day.

750
00:50:01,760 –> 00:50:05,280
I’ve tried other things, but
it is really quite discouraging

751
00:50:05,280 –> 00:50:07,840
going into work when
you’re feeling hungry.

752
00:50:09,640 –> 00:50:12,480
There’s another reason I’m
determined to try this regime.

753
00:50:12,480 –> 00:50:16,040
When I arrived home, I
had another IGF-1 test.

754
00:50:17,040 –> 00:50:21,280
Annoyingly, my levels
were higher than ever.

755
00:50:21,280 –> 00:50:27,800
Turns out the hard-won effects of the
four-day fast only lasted a short while.

756
00:50:27,800 –> 00:50:30,680
And she’s kind of running
with it at the moment, I think.

757
00:50:30,680 –> 00:50:33,920
‘So I hope this is
something I can stick to.’

758
00:50:33,920 –> 00:50:37,280
Good. It’s done. It’s
actually twenty to two,

759
00:50:37,280 –> 00:50:41,040
and I don’t feel remotely
hungry, but it is lunchtime,

760
00:50:41,040 –> 00:50:44,920
so if nothing else, I think I’m
going to go and prowl around.

761
00:50:44,920 –> 00:50:50,680
MUSIC: “Harder, Better,
Faster, Stronger” by Daft Punk

762
00:51:02,400 –> 00:51:06,840
I found that fasting when
I’m busy at work was doable,

763
00:51:06,840 –> 00:51:09,720
but the next big test is my holiday.

764
00:51:09,720 –> 00:51:11,880
I’m walking with some friends.

765
00:51:11,880 –> 00:51:17,080
We are doing a walk across
the Trans-Pennine Way.

766
00:51:17,080 –> 00:51:22,080
Had breakfast this morning
about two hours ago,

767
00:51:22,080 –> 00:51:28,200
and I’m planning on eating
next breakfast tomorrow.

768
00:51:28,200 –> 00:51:32,160
So far I am feeling quite good.

769
00:51:35,080 –> 00:51:39,960
It’s now about seven o’clock.
Haven’t eaten for about 12 hours.

770
00:51:39,960 –> 00:51:43,520
The others are behind
me in the pub eating,

771
00:51:43,520 –> 00:51:47,640
so I decided to come
outside for a bit, because…

772
00:51:47,640 –> 00:51:50,400
I’m not as strong-minded
as I thought I was.

773
00:51:50,400 –> 00:51:53,480
My stomach is begin to rumble
a bit, but it’s all right.

774
00:51:57,880 –> 00:52:02,400
‘It’s been five weeks since
I started the five/two diet.’

775
00:52:02,400 –> 00:52:04,720
Heel! Heel!

776
00:52:04,720 –> 00:52:06,920
Not very good dog!

777
00:52:06,920 –> 00:52:10,520
‘I managed to fit in two 600
calorie fast days each week,

778
00:52:10,520 –> 00:52:13,960
‘though they tended to
be a bit scattered around.

779
00:52:13,960 –> 00:52:16,440
‘But has it been enough
to make a difference?’

780
00:52:17,840 –> 00:52:19,640
So, today’s results day.

781
00:52:19,640 –> 00:52:21,520
I have lost, I know, some weight,

782
00:52:21,520 –> 00:52:25,000
I’ll find out in a moment just
how much, but I’m mainly interested

783
00:52:25,000 –> 00:52:29,200
in the bloods, because five or six
weeks ago they were pretty terrible.

784
00:52:29,200 –> 00:52:34,280
I have high blood glucose,
high cholesterol, high IGF.

785
00:52:34,280 –> 00:52:37,480
And I’m really, really
keen to see them improve,

786
00:52:37,480 –> 00:52:41,400
because frankly, if they haven’t
improved, then I am in trouble,

787
00:52:41,400 –> 00:52:46,480
and I do want to stay young and
healthy for my family, for myself.

788
00:52:46,480 –> 00:52:51,800
So, I’m quite anxious, because
this matters an awful lot to me.

789
00:52:55,000 –> 00:52:59,080
Just to remind you, this is what I
looked like at the start of this film.

790
00:53:01,160 –> 00:53:04,040
And this is me today.

791
00:53:04,040 –> 00:53:06,640
I’ve had to add a few
new holes to my belt,

792
00:53:06,640 –> 00:53:09,800
so I know that something
has changed, but by how much?

793
00:53:09,800 –> 00:53:14,400
Right, the moment of truth, in which I
discovered just how much weight I have lost.

794
00:53:14,400 –> 00:53:18,360
These are a special type of scales which
are going to measure my weight accurately,

795
00:53:18,360 –> 00:53:20,280
but also, apparently, my body fat.

796
00:53:20,280 –> 00:53:23,280
Hey! That is fantastic!

797
00:53:23,280 –> 00:53:31,240
That is 173.8lb, which means
I have lost well over a stone.

798
00:53:31,240 –> 00:53:36,280
My body fat when we
did it before was 27%,

799
00:53:36,280 –> 00:53:39,440
and now it’s below 20.

800
00:53:39,440 –> 00:53:42,560
That is really, really pleasing.

801
00:53:46,280 –> 00:53:50,960
I feel good, and my
family say I look slimmer.

802
00:53:50,960 –> 00:53:54,120
It really hasn’t been that difficult,

803
00:53:54,120 –> 00:53:58,280
and I’m delighted that I’m no
longer in the overweight category.

804
00:53:58,280 –> 00:54:02,400
But what I really want to know
is what’s changed inside my body.

805
00:54:06,920 –> 00:54:12,280
Professor Luigi Fontana is about
to call with my final results.

806
00:54:12,280 –> 00:54:15,160
Hi, Michael! Hi, Luigi, how are you?

807
00:54:15,160 –> 00:54:17,680
I’m fine, and you? I’m very good.

808
00:54:17,680 –> 00:54:19,200
So, we’ve got your results.

809
00:54:19,200 –> 00:54:23,880
Just by fasting two days a
week, you made a great impact

810
00:54:23,880 –> 00:54:28,760
on your cardiometabolic health,
and so I’m very proud of you.

811
00:54:28,760 –> 00:54:33,920
‘But what’s happened to my IGF-1?
Is my body still in go-go mode?’

812
00:54:33,920 –> 00:54:38,760
IGF-1 is the major
risk factor for cancer.

813
00:54:38,760 –> 00:54:42,080
Breast cancer, prostate
cancer, colon cancer.

814
00:54:42,080 –> 00:54:45,480
Both the three-and-a-half
day fasting

815
00:54:45,480 –> 00:54:51,840
and the five weeks’ intermittent
fasting dropped your IGF-1 by 50%.

816
00:54:53,360 –> 00:54:56,600
‘Which is enough to reduce
my risk of certain cancers.

817
00:54:56,600 –> 00:55:00,240
‘But what about my blood sugar,
which was borderline diabetic?’

818
00:55:00,240 –> 00:55:05,560
Your glucose dropped
to 90. Right. Fantastic.

819
00:55:05,560 –> 00:55:07,640
So your glucose became normal again.

820
00:55:07,640 –> 00:55:10,760
‘My final result is cholesterol.’

821
00:55:10,760 –> 00:55:15,320
So, you had a reduction
in total cholesterol,

822
00:55:15,320 –> 00:55:17,840
and in an increase in
the good cholesterol.

823
00:55:17,840 –> 00:55:21,920
This shows how little
it takes, you know,

824
00:55:21,920 –> 00:55:26,160
to improve without drugs,
without taking medication.

825
00:55:26,160 –> 00:55:29,120
‘It wasn’t THAT little an effort,

826
00:55:29,120 –> 00:55:34,520
‘but I have cut my risk of developing
diseases which could shorten my life.’

827
00:55:34,520 –> 00:55:37,680
Thank you. So, I should live
happily ever after, should I?

828
00:55:37,680 –> 00:55:40,200
I don’t know if you’re
going to live happier,

829
00:55:40,200 –> 00:55:44,200
but you have a lower risk
of developing diseases.

830
00:55:44,200 –> 00:55:47,440
Thank you very much, Luigi,
really, thank you. You’re welcome.

831
00:55:47,440 –> 00:55:50,600
I’m very, very pleased.
Very pleased indeed.

832
00:55:50,600 –> 00:55:53,920
That was far better
than I was expecting.

833
00:55:55,400 –> 00:56:00,520
‘I wanted my wife Claire, who
is a GP, to share my results.’

834
00:56:00,520 –> 00:56:05,840
So, this is my IGF, which is
kind of my cancer/ageing risk.

835
00:56:05,840 –> 00:56:10,440
This one’s come down to half
on the two-day fasting. Yes.

836
00:56:10,440 –> 00:56:14,560
All of them have shown the improvement
that you, kind of, hoped for.

837
00:56:14,560 –> 00:56:15,720
Yes.

838
00:56:15,720 –> 00:56:19,040
That basically means you’re not going to
have to take tablets at all, at the moment.

839
00:56:19,040 –> 00:56:20,280
No. If you stick to it.

840
00:56:21,400 –> 00:56:24,080
Well, you’re looking good on it.

841
00:56:24,080 –> 00:56:26,160
Thank you. No, I’m really pleased.

842
00:56:26,160 –> 00:56:28,960
I have to say that’s really,
amazingly good news. Mmm.

843
00:56:33,400 –> 00:56:37,840
The results have been
absolutely fantastic for me,

844
00:56:37,840 –> 00:56:42,000
but that doesn’t mean that intermittent
fasting will work for everyone.

845
00:56:44,200 –> 00:56:48,200
It’s really important that
they do more trials on humans,

846
00:56:48,200 –> 00:56:51,320
to find out if, in the long
term, it is safe and effective.

847
00:56:53,760 –> 00:56:58,760
But having experienced intermittent
fasting, I plan to go on doing it.

848
00:56:59,880 –> 00:57:03,240
It seems to have undone
some of the damage

849
00:57:03,240 –> 00:57:05,880
that I have done to
my body down the years.

850
00:57:08,920 –> 00:57:12,040
It is very poignant looking
at the photographs of myself

851
00:57:12,040 –> 00:57:15,160
and members of my family
growing up and growing older,

852
00:57:15,160 –> 00:57:18,640
but it doesn’t make me want
to hold back the hands of time.

853
00:57:18,640 –> 00:57:23,920
I sort of think that we do
grow old, we should grow old,

854
00:57:23,920 –> 00:57:26,920
and there’s very little
we can do about it.

855
00:57:26,920 –> 00:57:31,680
But fasting is somehow different. Fasting
is not about trying to live to 140,

856
00:57:31,680 –> 00:57:35,880
it’s about staying healthy
for as long as you can,

857
00:57:35,880 –> 00:57:39,280
and with the sort of time
bomb we’re facing as a nation,

858
00:57:39,280 –> 00:57:42,240
with obesity going
up, diabetes going up,

859
00:57:42,240 –> 00:57:45,960
we desperately need something
which can make a difference.

860
00:57:45,960 –> 00:57:49,480
Fasting is the first
thing I’ve come across

861
00:57:49,480 –> 00:57:52,840
that I genuinely believe that
if people were to take it up,

862
00:57:52,840 –> 00:57:56,840
it could radically transform
the nation’s health.

863
00:57:56,840 –> 00:58:03,360
So, I hope that we continue to see
massive research going into this territory.

864
00:58:04,560 –> 00:58:08,240
Doing this fasting has been
one of the most interesting…

865
00:58:08,240 –> 00:58:11,600
no, I would say THE most
interesting sort of journey, film,

866
00:58:11,600 –> 00:58:14,240
whatever you want to call
it, that I have been on.

867
00:58:14,240 –> 00:58:16,320
DOG WHIMPERS

868
00:58:16,320 –> 00:58:18,520
And I’ve never said that before.

869
00:58:32,000 –> 00:58:35,640
Subtitles by Jozef Jarosciak

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