Hruby Slovensky preklad titulkov pre program: BBC Horizon 2012 – Epizodu 03 – Eat, Fast And Live Longer (Jedz, pôsti sa a ži dlhšie):
Tu je cele video v horsej kvalite (Vimeo.com – 297MB):
BBC – Eat, Fast And Live Longer (Jedz, pôsti sa a ži dlhšie) from Jozef on Vimeo.
A tu to je v originalnej kvalite (DailyMotion.com – 769MB):
BBC – Eat, Fast And Live Longer (Jedz, pôsti sa…by jozef-zilina
A ak by chcel niekto upravit titulky, tu su ako v Slovencine, tak aj v Anglictine (akurat mi potom poslite novu kopiu v komentari alebo emailom):
—–
Slovenske Titulky:
1
00:00:07,040 –> 00:00:09,000
Milujem zivot,
2
00:00:09,000 –> 00:00:13,280
a preto chcem zostat mlady a energicky,
a uzivat si to tak dlho, ako to len pojde.
3
00:00:13,280 –> 00:00:15,480
Mam lekarsky trening.
4
00:00:15,480 –> 00:00:19,360
A som si vedomy vsetkych
odporuceni o tom ako mam zostat zdravy.
5
00:00:19,360 –> 00:00:23,120
Ale v mojom pripade to
nejako proste nefunguje.
6
00:00:24,760 –> 00:00:29,800
Zistil som, ze moje telo uz nie je
ten stihly a trvanlivy pristroj
7
00:00:29,800 –> 00:00:31,800
ktorym by som chcel aby bolo.
8
00:00:31,800 –> 00:00:37,480
Tretina vasho tela je tuk. Dakujem!
Ze ste to tak zroraznili.
9
00:00:37,480 –> 00:00:42,400
Chcel som vidiet, ci veda moze ponuknut
nejaky iny sposob, ako zastavit starnutie,
10
00:00:42,400 –> 00:00:44,560
spomalit hodiny,
11
00:00:44,560 –> 00:00:48,000
a tak som vyrazil najst odbornikov
12
00:00:48,000 –> 00:00:51,520
ktori sa snazia bojovat
proti starnutiu.
13
00:00:51,520 –> 00:00:54,760
Tu od zakladu prepisujeme ludsku
fyziologiu. Ooh … joj!
14
00:00:56,160 –> 00:01:00,440
Ak sa vam podari najst nieco ine, co
nebude boliet a bude mat tie iste vyhody,
15
00:01:00,440 –> 00:01:03,440
a bude sposobovat taketo uzasne
zmeny, rad by som o tom vedel.
16
00:01:05,160 –> 00:01:08,200
Co som zistil, bolo naozaj prekvapujuce.
17
00:01:09,800 –> 00:01:14,640
Nejedna sa o ziadne tabletky, ziadne
injekcie a nema to ziadne skryte naklady.
18
00:01:14,640 –> 00:01:17,400
Je to vsetko otazka len a len toho, co jete.
19
00:01:17,400 –> 00:01:19,400
Alebo lepsie povedane, toho co nejete.
20
00:01:20,920 –> 00:01:25,480
Vcera v noci sa mi snivalo ze som jedol sendvic
a potom som sa citil hrozne previnilo.
21
00:01:25,480 –> 00:01:26,840
Je to cele o poste.
22
00:01:26,840 –> 00:01:30,120
A ako sa postit co jednoduchsie!
23
00:01:30,120 –> 00:01:32,400
A ak by som isiel na Joe-ov zivotny styl…?
24
00:01:32,400 –> 00:01:36,200
Do roka budete uplne vylieceny!
25
00:01:42,480 –> 00:01:48,600
Velkou prednostou je, ze je to zaciatok
niecoho, co si myslim, ze by mohol byt velmi vyznamne.
26
00:01:48,600 –> 00:01:51,480
A ak sa to chyti a pojde v spravnom
smere… Viem si predstavit, ze to aj bude
27
00:01:51,480 –> 00:01:54,920
a moze byt
skutocne nieco revolucne.
28
00:02:10,840 –> 00:02:12,720
(Klakson)
29
00:02:18,520 –> 00:02:23,160
Existuje vela ludi, co
zostavaju relativne mladymi a fit
30
00:02:23,160 –> 00:02:25,160
aj po dosiahnuti dochodkoveho veku.
31
00:02:33,480 –> 00:02:36,320
Vacsinou to dosiahnu tradicnym sposobom –
32
00:02:36,320 –> 00:02:39,120
hlavne prostrednictvom cvicenia.
33
00:02:39,120 –> 00:02:42,280
Dnes som prisiel na Londynsky maraton.
34
00:02:42,280 –> 00:02:47,000
Takmer 36 tisic ludi
vsetkych tvarov a velkosti
35
00:02:47,000 –> 00:02:49,360
ktory sa snazia pokorit 42km dlhu trasu.
36
00:02:49,360 –> 00:02:51,480
Niektory z nich su mladici,
37
00:02:51,480 –> 00:02:53,400
vela znich vsak uz nie az tak mladych.
38
00:03:00,560 –> 00:03:03,920
Je tu uplne
fantasticka atmosfera.
39
00:03:03,920 –> 00:03:05,760
Doteraz som nikdy nebezal maraton
40
00:03:05,760 –> 00:03:08,560
a pravdu povediac, tiez nemam ziadne plany
niekedy maraton bezat,
41
00:03:08,560 –> 00:03:12,160
ale dneska tu je vela
ludi co bezat budu a
42
00:03:12,160 –> 00:03:15,160
su ovela starsi nez som ja sam.
43
00:03:15,160 –> 00:03:18,880
Je tu 7 tisic ludi nad 50 rokov
44
00:03:18,880 –> 00:03:21,480
a co je uplne neuveritelne,
45
00:03:21,480 –> 00:03:25,560
je tu sedem ludi, co su
starsi nez 80 rokov.
46
00:03:31,320 –> 00:03:35,280
Budem sa snazit
niektorych z nich
47
00:03:35,280 –> 00:03:37,200
opytat, ako to vlastne robia.
48
00:03:37,200 –> 00:03:39,560
Dobry den! Ako sa mate? Dobry den!
49
00:03:40,760 –> 00:03:42,720
Kolko mate rokov? 78.
50
00:03:42,720 –> 00:03:44,360
A kolko mate rokov vy? 81.
51
00:03:50,960 –> 00:03:54,280
Ake je tajomstvo?
Beh? Nie, kuzelna palicka :)
52
00:03:54,280 –> 00:03:57,520
Len dobre jest. Tvrdo
pracovat synak, to je vsetko!
53
00:03:59,120 –> 00:04:04,200
Kazdy, kto dokaze ubehnut maraton
v 70tke si zasluzi moju uctu,
54
00:04:04,200 –> 00:04:10,000
ale ja cakam na muza, pri ktorom
osemdesiatnici vyzeraju mlado.
55
00:04:13,920 –> 00:04:16,440
Fauja Singh je niekto uplne uzasny.
56
00:04:16,440 –> 00:04:19,120
Bol aktivny po cely zivot,
57
00:04:19,120 –> 00:04:22,800
a seriozne sa zacal venovat
behu az v jeho 80tke.
58
00:04:22,800 –> 00:04:27,640
Co to je, co ho drzi
tak pozoruhodne fit?
59
00:04:27,640 –> 00:04:31,200
Dobry den. Rad Vas vidim.
60
00:04:31,200 –> 00:04:34,080
Kolko rokov ma Fauja? 101.
61
00:04:34,080 –> 00:04:37,000
Narodil sa 1. Aprila 1911.
62
00:04:37,000 –> 00:04:41,000
Bohuzial nie este docela
zvladol anglicky jazyk.
63
00:04:41,000 –> 00:04:44,200
Nebude vam vadit, ak sa opytam ako sa citi?
64
00:04:44,200 –> 00:04:46,360
(Hovoria Pandzabsky)
65
00:04:49,440 –> 00:04:51,680
Povedal, “Nie je to az take lahke …” Ano?
66
00:04:51,680 –> 00:04:56,960
Ale chce dokoncit co zacal, a stale este
neskoncil. Nejdete to vzdat, ze nie?
67
00:05:02,840 –> 00:05:05,200
Aj ked ma 101 rokov,
68
00:05:05,200 –> 00:05:09,160
Fauja nikdy nebol na ziadnej operacii,
69
00:05:09,160 –> 00:05:13,440
nema ziadne priznaky akejkolvek choroby srdca …
70
00:05:13,440 –> 00:05:16,320
a neberie ziadne lieky.
71
00:05:20,160 –> 00:05:23,040
Veri, ze za jeho dlhu zivotnost
72
00:05:23,040 –> 00:05:26,240
a jeho neuveritelne zdravie
je zodpovedna hlavne jeho strava.
73
00:05:28,480 –> 00:05:30,680
Takze, nejaka specialna dieta?
74
00:05:30,680 –> 00:05:33,200
Nema ziadnu zvlastnu dietu.
75
00:05:33,200 –> 00:05:39,200
Je to jednoducha dieta Punjabskeho farmara
, cize len cerstve potraviny,
76
00:05:39,200 –> 00:05:42,080
ale jeho tajomstvom je, ze
jedava len mensie porcie. Vazne.
77
00:05:42,080 –> 00:05:45,040
V chudobnych krajinach,
ludia umieraju hladom.
78
00:05:45,040 –> 00:05:48,600
V bohatych krajinach,
ludia umieraju na prejedanie.
79
00:05:48,600 –> 00:05:52,080
Tak, ake velke su jeho porcie
, co ja viem, v porovnani s Vami, alebo mnou?
80
00:05:52,080 –> 00:05:55,120
On zje asi tolko co by bola
klasicka polovicna porcia,
81
00:05:55,120 –> 00:05:57,640
cize nieco co by sa dalo nazvat detskou porciou.
82
00:05:57,640 –> 00:06:02,000
Cize detska porcia je pravdepodobne asi polovica
mnozstva kalorii, ktoru by som ja, ci vy zjedli?
83
00:06:04,840 –> 00:06:08,720
Obmedzenim jeho prijmu
jedla tak dramaticky,
84
00:06:08,720 –> 00:06:12,960
Fauja nevedomky testuje
teoriu, ktora existuje
85
00:06:12,960 –> 00:06:15,280
skoro tak dlho, ako je sam nazive.
86
00:06:17,480 –> 00:06:21,680
Je to vedecka teoria, ktora vsak az
teraz naozaj vstupuje do povedomia!
87
00:06:26,920 –> 00:06:30,720
Vzal som si autobus az k cielovej ciare.
88
00:06:30,720 –> 00:06:33,760
Chcem zachytit ako sa Fauja stane, dufajme,
89
00:06:33,760 –> 00:06:36,960
najstarsim maratonskym bezcom na svete.
90
00:06:44,880 –> 00:06:49,800
A po siedmich hodinach a
49 minutach, uspel.
91
00:06:49,800 –> 00:06:52,920
(Fandenie a potlesk)
92
00:06:55,760 –> 00:06:58,280
Mozem vam pogratulovat?
93
00:07:12,440 –> 00:07:15,960
To je uplne neuveritelne
– Ma 101 rokov
94
00:07:15,960 –> 00:07:19,080
a prave dokoncil 42 kilometrov
95
00:07:19,080 –> 00:07:22,480
Absolutne si neviem predstavit
ze taketo nieco by som dokazal za 50 rokov odteraz,
96
00:07:22,480 –> 00:07:24,800
ja asi budem behat akurat tak po nakupnom stredisku,
97
00:07:24,800 –> 00:07:27,200
ale chcel by som byt takym ako je on.
98
00:07:27,200 –> 00:07:32,080
Chcem byt dusevne aktivny a fyzicky
aktivny, a chcem zostat mladsi co najdlhsiu dobu.
99
00:07:42,680 –> 00:07:45,960
Po desatrocia, timy
vedcov po celom svete
100
00:07:45,960 –> 00:07:49,000
intenzivne studovali starnutie.
101
00:07:49,000 –> 00:07:55,560
Vcelku jednoznacne, geny hraju dolezitu rolu
v tom ako rychlo a ako kvalitne starneme,
102
00:07:55,560 –> 00:07:58,760
ale co sa tyka genov,
so svojou situaciou moc spravit nemozete.
103
00:07:58,760 –> 00:08:03,000
Avsak, je tu nieco
co mozete urobit, s tym co jete.
104
00:08:06,880 –> 00:08:11,960
A tu v Amerike, sa zacinaju
ukazovat vysledky niektorych naozaj pozoruhodne vyskumov
105
00:08:11,960 –> 00:08:14,600
ktore spajaju jedlo s dlhovekostou.
106
00:08:14,600 –> 00:08:20,200
Zda sa, ze to nie je len o tom, co
jeme, ale ako a kedy jeme
107
00:08:22,040 –> 00:08:27,480
Nas pribeh zacina v zaprasenych
tanierocha a miskach Ameriky pocas 30tich rokov.
108
00:08:27,480 –> 00:08:30,600
Vtedy bolo strasne
sucho, jedlo bolo vzacne,
109
00:08:30,600 –> 00:08:34,760
a cela krajina bola v
pazuroch velkej depresie.
110
00:08:34,760 –> 00:08:37,480
Dokazeme si predstavit,
ze asi v tychto tazkych casoch,
111
00:08:37,480 –> 00:08:42,040
priemerna dlzka zivota musela
klesat, ale skutocnost je taka, ze naopak rastla.
112
00:08:44,440 –> 00:08:49,600
Pocas najtemnejsich rokov
velkej hospodarskej krizy – 1929 az 1933 –
113
00:08:49,600 –> 00:08:53,960
sa priemerna dlzka zivota zvysila
o vyznamnych 6 rokov.
114
00:08:59,320 –> 00:09:03,080
Takto povedane,
je to nieco prekvapujuce,
115
00:09:03,080 –> 00:09:08,760
ale naznaky preco tomu tak je, zacali byt
viditelne az z vyskumov situacie v 30tich rokoch.
116
00:09:09,920 –> 00:09:13,320
Odbornici na vyzivu na Cornell
Univerzite pracujuci so zvieratami
117
00:09:13,320 –> 00:09:15,720
zistili, ze ak vazne obmedzite
118
00:09:15,720 –> 00:09:20,080
porcie ktore zvierata jedia, tak ziju dlhsie.
119
00:09:20,080 –> 00:09:22,840
Ovela, ovela dlhsie.
120
00:09:25,880 –> 00:09:30,640
Takze dalsia samozrejma otazka je
– Ak spravite to iste s ludmi,
121
00:09:30,640 –> 00:09:33,680
bude to mat rovnake ucinky?
122
00:09:35,640 –> 00:09:39,920
No, je to uz osem desatroci
od tohoto pozorovania,
123
00:09:39,920 –> 00:09:43,320
a az teraz vedci
zacinaju skutocne rozumiet
124
00:09:43,320 –> 00:09:47,360
linke medzi kalorickym
obmedzovanim a dlhovekostou u ludi.
125
00:09:47,360 –> 00:09:51,880
Az teraz, sa zda, zaciname
dostavat odpovede.
126
00:10:00,920 –> 00:10:06,000
Washington University je
srdcom tohto noveho vyskumu.
127
00:10:06,000 –> 00:10:09,080
Toto je miesto kde sa prepisuje ludska fyziologia!
128
00:10:09,080 –> 00:10:11,040
Je to uzasne, viete, to ze
129
00:10:11,040 –> 00:10:14,920
jednoducha zmena diety
moze zmenit v podstate
130
00:10:14,920 –> 00:10:17,840
uplne fungovanie celeho ludskeho tela.
131
00:10:19,720 –> 00:10:24,120
“Profesor Luigi Fontana stravil
poslednych desat rokov, studiom skupiny ludi
132
00:10:24,120 –> 00:10:28,520
ktori zavazne obmedzili svoj
denny kaloricky prijem.
133
00:10:30,280 –> 00:10:33,400
“A je neuveritelne prekvapeny
tym, co zistil. ”
134
00:10:34,920 –> 00:10:37,800
Tito ludia su,
ako uplne odlisny druh.
135
00:10:37,800 –> 00:10:40,240
To je dost velke
prehlasenie, nemyslite? Ano!
136
00:10:40,240 –> 00:10:45,040
Zistujeme, ze sa budu
dozivat dlhsie nez ich rodicia a bratia
137
00:10:45,040 –> 00:10:48,080
ktory su na typickej Americkej
strave, alebo typickej zapadnej diete.
138
00:10:53,440 –> 00:10:56,040
“Luigi je jednoznacne ohureny,
139
00:10:56,040 –> 00:11:00,920
“Tak som sa chcel sam stretnut s jednym z tych
ludi co oznacil ako uplne iny ludsky druh.”
140
00:11:00,920 –> 00:11:04,800
Krasny, naozaj krasny dom. Trafili
ste ku mne dobre? V pohode, dobre instrukcie, dakujem.
141
00:11:04,800 –> 00:11:07,280
Joe Cordell je ‘CRonie’ –
142
00:11:07,280 –> 00:11:10,640
to znamena ze sa kaloricky obmedzuje
a prijima len optimalnu vyzivu.
143
00:11:10,640 –> 00:11:14,240
To znamena, ze vela ovocia a zeleniny.
144
00:11:16,280 –> 00:11:18,800
Ja nez ste prisli som viac menej
vsetko vylozil
145
00:11:18,800 –> 00:11:22,920
Myslel som si, ze mozno budete chciet nejake
ranajky. To by bolo vynikajuce, dakujem.
146
00:11:22,920 –> 00:11:25,120
Ked si predstavujem obmedzenie kalorii,
147
00:11:25,120 –> 00:11:30,120
predstavujem si niekoho, kto zije v podstate na
par mrkvach, alebo nieco take.
148
00:11:30,120 –> 00:11:34,160
Nemyslel som si, ze si
naozaj date ranajky.
149
00:11:34,160 –> 00:11:37,720
“Joe zacina svoj den
s horou ovocia,
150
00:11:37,720 –> 00:11:40,360
“niektore casti vsak vyhadzuje.”
151
00:11:41,360 –> 00:11:45,840
Potom chcem pridat nejake jablko,
do toho, ale ked ste v mojej pozicii,
152
00:11:45,840 –> 00:11:50,840
chcete dostat co najviac nutricnej
hodnoty na celkove mnozstvo kalorii,
153
00:11:50,840 –> 00:11:53,480
a prakticky vsetka
nutricna hodnota je v supke jablka.
154
00:11:53,480 –> 00:11:56,960
Takze si nastruhate viac menej len supky
a zbytok zahodite?
155
00:11:56,960 –> 00:11:59,960
Robite presny opak
toho co robi vacsina ludi.
156
00:11:59,960 –> 00:12:04,160
Je to ok, doslova 95%
z nutricnej hodnoty je v supke …
157
00:12:04,160 –> 00:12:07,840
V supke? Ano.
Zvysok je viac menej len cukor a kalorie.
158
00:12:07,840 –> 00:12:11,480
To je viac menej to, co jedavam
kazde rano. Toto cele?
159
00:12:11,480 –> 00:12:13,080
Ano. To je velka misa.
160
00:12:13,080 –> 00:12:17,360
Zamyslate sa niekedy nad tym, ze, “Co ak toto
cele je nezmysel? Co ak to cele robim zle?”
161
00:12:17,360 –> 00:12:22,360
“Robim to 10 az 20 rokov, a
zrazu veda objavi nieco co povie
162
00:12:22,360 –> 00:12:25,200
“Toto cele je nezmysel.”
163
00:12:25,200 –> 00:12:28,840
Poviem vam, moj brat vazi
o 40kg viac ako ja,
164
00:12:28,840 –> 00:12:33,720
je v mojom veku a vzdy
si so mna utahuje,
165
00:12:33,720 –> 00:12:36,640
vravi mi casto, ze ma prezije
166
00:12:36,640 –> 00:12:39,280
a podla jeho nazoru,
trpim uplne zbytocne.
167
00:12:39,280 –> 00:12:41,360
Ale ide o to, ze ja to co robim, robim rad.
168
00:12:41,360 –> 00:12:44,000
Zdravy zivotny styl moze byt zabava.
169
00:12:44,000 –> 00:12:49,080
“Momentalne sa odhaduje
ze na celom svete je asi 100 tisic Cronies ako Joe –
170
00:12:49,080 –> 00:12:53,680
“ludi zijuci na diete
ktora je bohata na ziviny”
171
00:12:53,680 –> 00:12:55,520
– ale s nizkym obsahom kalorii.
172
00:12:55,520 –> 00:12:59,080
“Joe podla mna vyzera fit, ale
nie je nejak vyzorovo posobivo mlady.
173
00:12:59,080 –> 00:13:02,160
Mozno to Luigi trosku prehana.”
174
00:13:02,160 –> 00:13:05,480
Co by som chcel spravit, je zobrat
nas oboch a spravit zopar testov.
175
00:13:05,480 –> 00:13:07,120
Chcem vidiet, ako sa s nim zrovnavam.
176
00:13:07,120 –> 00:13:11,120
OK, som za. Takze, ideme na to?
177
00:13:11,120 –> 00:13:16,040
To je skutocne vyzva,… sutaz
ktoru mam podozrenie, asi prehram!
178
00:13:20,040 –> 00:13:25,360
Za poslednych desat rokov, Joe
jedol maximalne 1900 kalorii denne.
179
00:13:25,360 –> 00:13:28,720
Ja jem priemerne okolo 2300,
180
00:13:28,720 –> 00:13:31,560
vela z toho su vsak sisky a hamburgery.
181
00:13:31,560 –> 00:13:33,880
Kolko si myslite, ze vazite?
182
00:13:33,880 –> 00:13:37,640
Pravdepodobne okolo 82kg. Ooo, viac ako 82kg!
183
00:13:37,640 –> 00:13:39,280
Nadychnite sa!
184
00:13:39,280 –> 00:13:44,000
Mal by som mat okolo 59, 60, 61kg.
185
00:13:44,000 –> 00:13:46,480
Musime to posunut smerom nadol o jeden stupen.
186
00:13:46,480 –> 00:13:49,120
60kg. Presne ste to trafili.
187
00:13:51,240 –> 00:13:55,320
Sme obaja vyse 50tky,
ale naozaj si nemyslim, ze
188
00:13:55,320 –> 00:13:58,680
vyzerame ako odlisna
generacia, nie to este, ako odlisny ludsky druh.
189
00:13:58,680 –> 00:14:01,520
Tak ako sa lisime?
190
00:14:01,520 –> 00:14:05,280
Potrebujem aby ste teraz trosku
relaxovali. Sadnite si, a chvilku pocuvajte.
191
00:14:08,640 –> 00:14:12,880
Niektore z najjednoduchsich sposobov posudenia
starnutia nevyzaduju potrebne specialne vybavenie.
192
00:14:12,880 –> 00:14:14,240
Oh, toto zacina byt dobre.
193
00:14:14,240 –> 00:14:17,040
Balance je udrziavany vnutornym uchom.
194
00:14:21,560 –> 00:14:24,600
“Ako starnete, usne struktury sa zhorsuju
195
00:14:24,600 –> 00:14:27,120
a vas balance sa tak isto zhorsi.”
196
00:14:27,120 –> 00:14:30,920
Este raz. “Mozete sa otestovat
tym, ze budete stat na svojej slabsiej nohe
197
00:14:30,920 –> 00:14:32,720
So zavretymi ocami.”
198
00:14:32,720 –> 00:14:36,360
Ako dlho som urobil? 6.59
sekund. To nie je moc dobre.
199
00:14:36,360 –> 00:14:38,360
“To nie je vobec dobre.
200
00:14:38,360 –> 00:14:41,920
“Priemerny 55-rocny clovek
musi vydrzat aspon 8 sekund. ”
201
00:14:41,920 –> 00:14:43,760
Si uz na …
202
00:14:43,760 –> 00:14:47,720
Vysledok mas tak dobry
ako priemerny 20 rocny mladik.
203
00:14:47,720 –> 00:14:50,400
Okolo 30 sekund je to, co
maximalne zvladnu 20 rocny,
204
00:14:50,400 –> 00:14:52,960
a to je len jedna z tych zrucnosti
co dramaticky klesaju umerne s vekom.
205
00:14:52,960 –> 00:14:56,680
Myslim, ze ste mi ukazali
pointu. Stop. Mozete prestat, ano.
206
00:14:58,720 –> 00:15:03,040
“Dalsi dobry test je reakcny
cas, ktory tiez klesa s vekom. ”
207
00:15:03,040 –> 00:15:04,840
To nie je moc dobre. Ledva osem centimetrov.
208
00:15:04,840 –> 00:15:07,600
“Na tento test potrebuje len pravitko.
209
00:15:07,600 –> 00:15:11,320
“Vo vasom veku, a dobrom zdravi, by ste mali byt schopni
chytat pravitko okolo 12cm znacky. ”
210
00:15:13,200 –> 00:15:16,680
Velmi dobre. To bolo 11cm. Dari sa
vam velmi dobre, musim uznat.
211
00:15:21,480 –> 00:15:25,120
Luigiho metody su
viac vedecke.
212
00:15:25,120 –> 00:15:28,600
Urobili sme mnozstvo lekarskych testov,
213
00:15:28,600 –> 00:15:30,920
vratane vysetrenia krvi.
214
00:15:30,920 –> 00:15:34,680
Teraz, nam ide ukazat nase vysledky.
215
00:15:34,680 –> 00:15:37,800
Pocit, ako by ste sedeli
pred riaditelnov, ze?
216
00:15:37,800 –> 00:15:39,200
Cakanie na vysledky.
217
00:15:39,200 –> 00:15:43,160
Dostanem jednotku?
Ci dvojku, alebo az trojku?
218
00:15:43,160 –> 00:15:45,080
“Luigiho tvar mi hovori, ze
219
00:15:45,080 –> 00:15:48,480
to, co budem teraz
pocut, nebude dobra sprava. ”
220
00:15:48,480 –> 00:15:53,600
Celkovy telesny tuk u Joa je 11,5%.
221
00:15:53,600 –> 00:15:57,640
To je typicke pre super sportovcov.
222
00:15:57,640 –> 00:16:01,000
11% telesneho tuku je velmi nizke
223
00:16:01,000 –> 00:16:04,720
pre 54 az
55-rocneho muza.
224
00:16:04,720 –> 00:16:07,360
Vas tuk je presne 27,1%.
225
00:16:07,360 –> 00:16:09,240
Vyse tretina vasho tela je tuk.
226
00:16:09,240 –> 00:16:13,280
Dakujem … ze ste
to tak zdoraznili!
227
00:16:13,280 –> 00:16:17,640
“A este stale neskoncil
o mojom tuku. ”
228
00:16:17,640 –> 00:16:19,720
Brusny tuk je okolo 30%.
229
00:16:19,720 –> 00:16:23,760
Brusny tuk je naozaj zly.
230
00:16:23,760 –> 00:16:26,480
Cim vyssia hladina brusneho
tuku, tym vyssie je riziko
231
00:16:26,480 –> 00:16:29,560
rozvoja cukrovky 2. typu,
a kardiovaskularnych ochoreni.
232
00:16:29,560 –> 00:16:32,680
Nie je pochyb, ze to je tiez
rizikovy faktor pre rakovinu.
233
00:16:33,880 –> 00:16:37,920
Takze, v podstate, vas
kardio-metabolicky profil,
234
00:16:37,920 –> 00:16:39,920
nie je dobry. Na vas vek.
235
00:16:39,920 –> 00:16:42,400
Myslim, ze by ste mali nieco urobit,
nieco co najskor zmenit.
236
00:16:42,400 –> 00:16:44,800
Co mozem povedat tu, je, ze Joseph
237
00:16:44,800 –> 00:16:48,280
nebude trpiet na ziadne
kardiovaskularne ochorenie.
238
00:16:48,280 –> 00:16:50,480
Pre neho je uplne nemozne aby mal mozgovu prihodu,
239
00:16:50,480 –> 00:16:53,080
infarkt myokardu alebo srdcove zlyhanie.
240
00:16:53,080 –> 00:16:56,080
A zrovna tieto tri choroby su zodpovedne
241
00:16:56,080 –> 00:16:58,960
za 40% vsetkych umrti v USA a Velkej Britanii.
242
00:16:58,960 –> 00:17:02,280
Ziadna sanca, ze zomrie na cosi take?
Myslim, ze ma sancu tak jednu z miliona.
243
00:17:02,280 –> 00:17:06,040
A keby som presiel na jeho
zivotny styl…?
244
00:17:06,040 –> 00:17:08,560
Do roka, budete vylieceny.
245
00:17:12,360 –> 00:17:16,040
Az teraz som pochopil, o com Luigi hovoril.
246
00:17:16,040 –> 00:17:20,600
Je to, ako by sme boli
dva rozne ludske druhy.
247
00:17:20,600 –> 00:17:24,600
Joeova strava udrzuje
jeho organy v perfektnom stave.
248
00:17:24,600 –> 00:17:28,080
Zatial co moja dieta ohrozuje
moje zdravie, a to velmi rapidne.
249
00:17:30,480 –> 00:17:34,840
No, toto bolo velmi alarmujuce.
Luigi sa tiez moc nevyberal slovami.
250
00:17:34,840 –> 00:17:36,920
Hovoril o brusnom tuku.
251
00:17:36,920 –> 00:17:39,440
V skutocnosti, hovoril
hodne zrovna o mojom brusneho tuku.
252
00:17:39,440 –> 00:17:42,160
Nikdy som o sebe
neuvazoval ako o niekom viac menej zlozenom z tuku.
253
00:17:42,160 –> 00:17:45,120
Ale to boli vlastne
dve vizie ktore mi boli ukazane.
254
00:17:45,120 –> 00:17:48,240
Na jednej strane, smer ktorym budem pokracovat
ak nic nezmenim…
255
00:17:48,240 –> 00:17:53,000
Smerujem celkom zaiste
smerom k srdcovej chorobe, alebo niecomu este horsiemu.
256
00:17:53,000 –> 00:17:57,720
Na druhej strane je, co ak by som
vyskusal kaloricke obmedzovanie – post?
257
00:17:57,720 –> 00:18:01,960
Povedal, ze by som mohol byt
uplne vylieceny do roka.
258
00:18:01,960 –> 00:18:06,160
Moje rizikove faktory by sa mohli zmenit
z tych co ma spravia
259
00:18:06,160 –> 00:18:08,520
asi obetou srdcoveho infarktu,
260
00:18:08,520 –> 00:18:10,360
na sancu takeho niecoho – jedna k milionu.
261
00:18:10,360 –> 00:18:15,400
Ked si to poviete takto z ostra,
clovek zacne o tom hodne premyslat.
262
00:18:31,160 –> 00:18:35,920
Aj ked dokazy podporujuce
vyhody kalorickej restrikcie
263
00:18:35,920 –> 00:18:38,800
su silnejsie kazdym dnom,
264
00:18:38,800 –> 00:18:42,640
nemozem si vo vsetkej uprimnosti predstavit
ze by som robil nieco take, ako to co robi Joe.
265
00:18:45,080 –> 00:18:48,080
Co vo mne vytvara vcelku velku dilemu.
266
00:18:50,080 –> 00:18:53,480
Co naozaj chcem spravit, je sa pokusit
267
00:18:53,480 –> 00:18:57,880
pochopit sposob
akym kaloricke obmedzenie funguje,
268
00:18:57,880 –> 00:19:01,240
potom nejak z toho dostat
vsetky vyhody
269
00:19:01,240 –> 00:19:03,960
a cele to spravit tak, aby som vlastne moc nemusel robit.
270
00:19:03,960 –> 00:19:05,560
Som v Los Angeles,
271
00:19:05,560 –> 00:19:09,400
v meste co je zname svojou
honbou za mladostou.
272
00:19:09,400 –> 00:19:12,280
V skutocnosti, mnoho ludi si tu mysli,
273
00:19:12,280 –> 00:19:15,520
ze starnutie a
vrasky su niecim volitelnym.
274
00:19:15,520 –> 00:19:19,360
Nejdem ale vyhladat nieco tak
povrchneho ako je plasticky chirurg.
275
00:19:19,360 –> 00:19:23,280
Som tu aby som sa stretol s jednym z
najvacsich odbornikov na starnutie.
276
00:19:31,640 –> 00:19:34,280
Dobry den. Dobry den.
277
00:19:34,280 –> 00:19:39,400
Profesor Valter Longo studuje
zlozite mechanizmy, ktore kontroluju starnutie.
278
00:19:41,600 –> 00:19:47,120
Vedie vyskum o kritickych cestach
co linkuju ako a co jeme, s tym ako starneme.
279
00:19:49,400 –> 00:19:52,360
Berie ma, aby som sa pozrel na dve specielne mysi.
280
00:19:52,360 –> 00:19:58,160
Obe su rovnakeho
veku, rovnakeho druhu a rovnakeho pohlavia.
281
00:19:58,160 –> 00:20:02,040
Ale je medzi nimi jeden
vyznamny rozdiel.
282
00:20:02,040 –> 00:20:06,040
Ta mala myska bude
zit ovela ovela dlhsie
283
00:20:06,040 –> 00:20:08,120
nez ta velka.
284
00:20:11,320 –> 00:20:13,560
Tato myska tu
285
00:20:13,560 –> 00:20:17,720
drzi svetovy rekord v
predlzeni veku u cicavcov.
286
00:20:17,720 –> 00:20:19,920
Oh, naozaj. To je pozoruhodne.
287
00:20:19,920 –> 00:20:22,840
Tak, ako dlho tento
poddruh mysky vydrzi?
288
00:20:22,840 –> 00:20:25,560
Tato velka mys sa dozije asi dva roky,
289
00:20:25,560 –> 00:20:28,480
a tato mala myska tu,
sa dozije asi o 40% dlhsie.
290
00:20:28,480 –> 00:20:30,880
Vazne. Su tak velmi
odlisne?
291
00:20:30,880 –> 00:20:33,120
Whoa! Snazi sa ma uhryznut.
292
00:20:33,120 –> 00:20:35,600
(Smiech)
293
00:20:35,600 –> 00:20:40,120
Citil som, ako presiel zub cez rukavicu.
Mali by sme si dat dvojite rukavice.
294
00:20:40,120 –> 00:20:43,360
Ano, naucil som sa to na vlastnej kozi!
295
00:20:43,360 –> 00:20:46,400
Ta velka mys ma uz
teraz 50% pravdepodobnost, ze onedhlo bude mrtva.
296
00:20:46,400 –> 00:20:48,560
OK, takze sa jej dari vcelku dobre, ak je este stale nazive?
297
00:20:48,560 –> 00:20:51,000
Ma stastie, ze je nazive, to je pravda.
298
00:20:51,000 –> 00:20:54,680
Ta mala ma pred sebou naopak este najmenej
dalsi rok zivota. O, dobre.
299
00:20:54,680 –> 00:20:57,640
Ta mala myska bude zit asi
ekvivalent toho, co by bolo 120 rokov u cloveka?
300
00:20:57,640 –> 00:21:02,680
Presne tak, v prepocte akoby dalsich 30
az do 40 rokov, v ludskych rokoch.
301
00:21:02,680 –> 00:21:06,920
Mozem si ju zdvihnut? Jasne
, za chvost. OK.
302
00:21:10,040 –> 00:21:11,680
Mala myska co drzim
303
00:21:11,680 –> 00:21:15,160
je vlastne umely vytvor.
304
00:21:15,160 –> 00:21:18,520
Dovod, preco je taka
mala a tak dlho zije
305
00:21:18,520 –> 00:21:21,720
je v tom, ze je
geneticky modifikovana.
306
00:21:21,720 –> 00:21:26,000
Ma neuveritelne nizku
hladinu rastoveho hormonu
307
00:21:26,000 –> 00:21:29,080
takzvaneho inzulin rastoveho faktoru 1, alebo IGF-1.
308
00:21:29,080 –> 00:21:32,240
A zda sa, ze IGF-1 je klucovym faktorom
309
00:21:32,240 –> 00:21:35,760
spajajucim obmedzenie kalorii
s dlhovekostou.
310
00:21:42,080 –> 00:21:46,240
Naznaky toho preco tomu tak je, sme zistili
pozorovanim skupiny ludi
311
00:21:46,240 –> 00:21:48,880
zijucich v odlahlej oblasti Ekvadoru.
312
00:21:50,720 –> 00:21:54,760
Maju velmi zriedkavy
stav, tzv. Laronov syndrom,
313
00:21:54,760 –> 00:21:58,960
ktory postihuje menej ako
350 ludi na celom svete.
314
00:22:03,360 –> 00:22:05,960
To ste vy, ze ano? Na tej fotke
vyzerate ako obor, ze?
315
00:22:05,960 –> 00:22:08,600
Medzi nimi som vzdy ten najvyssi.
316
00:22:08,600 –> 00:22:13,120
Najmensi z nich je len nieco malo cez
meter vysoky.
317
00:22:13,120 –> 00:22:15,160
Tak to je zhruba vo vyske pupku.
Je to pravda? Ano.
318
00:22:15,160 –> 00:22:20,840
“Co zaujma vedcov
ako Valter vsak nie je ich velkost,
319
00:22:20,840 –> 00:22:25,960
, ale skutocnost, ze sa zdaju byt prakticky
imunny na dvoch z najvacsich zabijakov zapadnej spolocnosti.”
320
00:22:25,960 –> 00:22:27,680
Velkym objavom pre nas bolo, ,
321
00:22:27,680 –> 00:22:31,160
ze, tato skupina netrpi
ci uz cukrovkou alebo rakovinu.
322
00:22:31,160 –> 00:22:33,720
Robia vsetko normalne,
presne tak ako to robi vela z nas,
323
00:22:33,720 –> 00:22:37,160
piju, fajcia, a tak?
Ano, robia vsetko normalne, a aj viac,
324
00:22:37,160 –> 00:22:39,760
a vedu vela krat velmi nezdravy zivotny styl.
325
00:22:39,760 –> 00:22:43,720
Vacsina z nich trpi v urcitom rozsahu
nadvahou.
326
00:22:43,720 –> 00:22:46,520
Zda sa, ze naozaj sa nedivaju
a nesleduju to co robia.
327
00:22:46,520 –> 00:22:49,640
Fajcia a jedia velmi
vysoko kaloricku stravu,
328
00:22:49,640 –> 00:22:53,440
a potom sa na mna pozru a povedia,
329
00:22:53,440 –> 00:22:55,080
“Ale co, to nevadi. Ved som imunny.”
330
00:22:55,080 –> 00:22:59,480
Co je neuveritelne
je, ze neexistuje ziadna evidencia
331
00:22:59,480 –> 00:23:02,920
ze by co len jeden z nich
niekedy umrel na rakovinu,
332
00:23:02,920 –> 00:23:06,640
zatial co vsak ich normalny vysoky pribuzny
dostanu rakovinu ako vacsina z nas.
333
00:23:08,000 –> 00:23:13,000
Ludia s Laronovym syndromom maju
geneticku mutaciu, ktora ich robi malymi,
334
00:23:13,000 –> 00:23:17,280
ale ktora ich ochranuje
proti skoro vsetkym ochoreniam.
335
00:23:19,320 –> 00:23:21,440
Je to neuveritelne, pracovat s nimi.
336
00:23:23,640 –> 00:23:29,120
Je to dobra skupina, a samozrejme pre
nas je to skupina, ktora nam vdaka jednej mutacii,
337
00:23:29,120 –> 00:23:33,480
moze povedat hodne o cukrovke, rakovine,
kardiovaskularnych ochorenia a starnuti.
338
00:23:37,240 –> 00:23:40,440
Ekvadorsky dedincania
a dlho zijuce mysi
339
00:23:40,440 –> 00:23:42,720
maju nieco spolocne.
340
00:23:42,720 –> 00:23:46,240
Ich telo produkuje
vynimocne nizke urovne
341
00:23:46,240 –> 00:23:48,080
rastoveho hormonu IGF-1.
342
00:23:50,520 –> 00:23:56,440
Tento objav pomohol Valterovi dat si
dokopy suvis uloh, ake ma IGF-1
343
00:23:56,440 –> 00:23:59,400
v zlozitom procese starnutia.
344
00:23:59,400 –> 00:24:02,800
Nase tela su
zvycajne v rezime rychlo-rychlo –
345
00:24:02,800 –> 00:24:07,560
bunky su neustale pohanane
IGF-1 aby sa delili.
346
00:24:07,560 –> 00:24:10,400
Ale ked hladina IGF-1 poklesne,
347
00:24:10,400 –> 00:24:14,080
nase bunky sa presunu do
uplne odlisneho rezimu.
348
00:24:14,080 –> 00:24:17,480
Telo zacne spomalovat tvorbu novych buniek
349
00:24:17,480 –> 00:24:20,800
a zacne opravovat
existujuce bunky.
350
00:24:20,800 –> 00:24:25,520
Poskodena DNA sa zacne opravovat.
351
00:24:25,520 –> 00:24:29,480
A to je to, preco su mysi a tiez
dedincania takto chraneny
352
00:24:29,480 –> 00:24:31,600
od veku pribuznych chorob.
353
00:24:40,480 –> 00:24:44,160
Ale ake je tu suvislost s
kalorikym obmedzovanim u ludi?
354
00:24:44,160 –> 00:24:49,960
Valter postavil velmi
jednoduchu, velmi Californsku analogiu.
355
00:24:51,440 –> 00:24:55,040
Ukazuje sa, ze je
nieco v potravinach, ktore jeme
356
00:24:55,040 –> 00:24:59,280
nieco co ovplyvnuje, ako vela
IGF-1 nase telo bude produkovat.
357
00:24:59,280 –> 00:25:01,880
Tym niecim su bielkoviny: Protein.
358
00:25:02,920 –> 00:25:07,800
Ked jeme vela bielkovin, nase
bunky doslova zostavaju zamknute v rychlo-rychlo rezime.
359
00:25:07,800 –> 00:25:10,920
Takze je to v podstate ako keby
ste dali nohu na plyn,
360
00:25:10,920 –> 00:25:13,320
a prikazal: “Ideme! Ideme! Rychlo!”
Je to tak? Presne tak.
361
00:25:13,320 –> 00:25:17,000
Je to nieco co tlaci bunku aby spalovala co najviac paliva.
362
00:25:17,000 –> 00:25:19,000
V rychlo-rychlo rezime,
363
00:25:19,000 –> 00:25:22,800
je telo nachylnejsie
na niektore druhy rakoviny a cukrovky,
364
00:25:22,800 –> 00:25:25,120
viac menej preto, ze vase bunky rastu prilis rychlo
365
00:25:25,120 –> 00:25:27,440
na to aby ich telo dokazalo efektivne opravovat.
366
00:25:27,440 –> 00:25:30,760
Takze je to ako neustala
jazda autom
367
00:25:30,760 –> 00:25:32,560
bez toho aby ste ho niekedy vzali k mechanikovi.
368
00:25:32,560 –> 00:25:36,160
Dobre, takze to bude to,
v podstate, nejako najst sposob, ako
369
00:25:36,160 –> 00:25:39,120
prepnut telo
z neustaleho “Brm, brm, brm,”
370
00:25:39,120 –> 00:25:44,080
do opravneho rezimu, “Vypni na chvilu
, skus mi opravit moju DNA.” Presne tak!
371
00:25:46,480 –> 00:25:49,400
Takze, ako mam ale znizit hladinu mojho IGF-1?
372
00:25:50,520 –> 00:25:54,560
No, studie o kalorickom obmedzovani
navrhuju, ze jest menej velmi pomaha,
373
00:25:54,560 –> 00:25:55,960
ale samo o sebe to nestaci.
374
00:25:57,040 –> 00:26:01,280
Nie len obmedzenie kalorii, ale
musi sa tiez vyznamne obmedzit prijem bielkovin.
375
00:26:01,280 –> 00:26:05,640
Nie uplne
– to by bol velmi zly napad.
376
00:26:05,640 –> 00:26:08,520
Je to o tom udrzat sa
v urcitych medziach,
377
00:26:08,520 –> 00:26:11,800
nieco, co vacsina z nas nerobi.
378
00:26:11,800 –> 00:26:15,840
A naozaj nemusite byt
CRonie na to aby ste znizili IGF-1!
379
00:26:15,840 –> 00:26:18,840
Existuje iny sposob,a to:
Post.
380
00:26:18,840 –> 00:26:25,560
Pocas postu, nastava daleko
dramatickejsia a ovela rychlejsia odozva,
381
00:26:25,560 –> 00:26:30,880
a to uz po 24 hodinach nejedenia,
sa znizi hladina glukozy
382
00:26:30,880 –> 00:26:35,480
a potom sa ako odozva tiez znizi hladina
rastoveho faktoru, ktorym je IGF-1.
383
00:26:38,360 –> 00:26:42,960
Pre mna je velmi tazko uverit,
ze len par dni postu
384
00:26:42,960 –> 00:26:47,480
by malo nakopnut moje
telo do uplne ineho, zdraveho stavu.
385
00:26:49,200 –> 00:26:53,720
Ale rozhodne ma to zaujalo,
a tak sa chcem dozvediet viac.
386
00:26:53,720 –> 00:26:56,360
Tak som si dal zmerat svoj IGF
v Londyne,
387
00:26:56,360 –> 00:26:59,200
a povedali mi, ze je to presne 28.
388
00:26:59,200 –> 00:27:01,200
Je to dobre? Ci zle?
389
00:27:01,200 –> 00:27:05,160
No nie je to zle,
ale je to stale dost vysoke…
390
00:27:05,160 –> 00:27:09,160
Na zaklade viacerych
studii, vratane tej nasej,
391
00:27:09,160 –> 00:27:14,480
vas toto cislo posuva do vyssej kategorie rizika
pre niekolko roznych druhov rakoviny,
392
00:27:14,480 –> 00:27:16,840
vratane rakoviny prostaty.
393
00:27:16,840 –> 00:27:21,320
Valter sa domnieva, by som mal vidiet
pomerne posobive vysledky
394
00:27:21,320 –> 00:27:25,400
uz po zhruba troch dnoch a
styroch nociach postu.
395
00:27:25,400 –> 00:27:27,680
Ale je to sklucujuca vyhliadka.
396
00:27:29,040 –> 00:27:32,080
Myslim, ze drzat post je tazke,
ze? Uz ste to niekedy robili?
397
00:27:32,080 –> 00:27:34,280
Ano, skusil som to,
398
00:27:34,280 –> 00:27:38,280
postil som sa po styri dni uz niekolkokrat
399
00:27:38,280 –> 00:27:39,920
a pre mna sameho to bolo dost tazke, ano.
400
00:27:39,920 –> 00:27:43,360
Ale robim to stale,… avsak ked sa pozeram
dopredu na prichadzajuci post,
401
00:27:43,360 –> 00:27:46,800
stale to vidim ako styri
dni, na ktore sa moc netesim.
402
00:27:46,800 –> 00:27:48,920
Niektori ludia sa na to tesia, ale ja nie.
403
00:27:48,920 –> 00:27:52,600
Som Talian, takze sa tesim
na to kedy sa zase dobre najem, to viete.
404
00:27:52,600 –> 00:27:55,200
Budem si vas obraz drzat v mysli…
405
00:27:55,200 –> 00:27:58,240
Ako sa nenasytny talian zdrzal jedenia.
Pripomeniem si to ked sa budem citit slaby.
406
00:27:58,240 –> 00:27:59,440
To je ono. Dakujem.
407
00:28:08,520 –> 00:28:11,480
Dlhsi post moze byt nebezpecny
408
00:28:11,480 –> 00:28:15,080
a Valter si mysli, ze by to mali
robit len ludia v dobrom zdravotnom stave
409
00:28:15,080 –> 00:28:18,240
a pokial mozno, pod starostlivym dohladom.
410
00:28:18,240 –> 00:28:20,120
Takze sme sa dohodli, ze bude na mna dohliadat.
411
00:28:21,760 –> 00:28:26,360
OK, rozhodol som sa, ze
idem ten post teda vyskusat,
412
00:28:26,360 –> 00:28:29,280
a bude to
presne tri a pol dnovy post
413
00:28:29,280 –> 00:28:35,120
a jedine co mozem mat je
vela vody a cierny caj
414
00:28:35,120 –> 00:28:39,520
a jednu 50-kaloriovu
polievku za den.
415
00:28:39,520 –> 00:28:44,680
A ide sa na to … O Boze, nikdy som nic
podobne este nespravil,
416
00:28:44,680 –> 00:28:46,920
tak si predstavujem, ze to bude
pre mna naozaj tazke.
417
00:28:46,920 –> 00:28:49,000
Ale som na to zvedavy.
418
00:28:49,000 –> 00:28:52,640
Tiez, musim priznat, ze
som docela znepokojeny niektorymi
419
00:28:52,640 –> 00:28:55,880
zlymi spravami o mojom zdravi
, spravy ktore som v poslednom case dost dostaval,
420
00:28:55,880 –> 00:29:01,960
takze, hm … je to pre mna vyzva,
ale som si isty, ze to nejak zvladnem.
421
00:29:03,360 –> 00:29:05,720
Viac menej isty,.
422
00:29:08,520 –> 00:29:10,920
A tak, moj post zacina!
423
00:29:17,480 –> 00:29:22,600
No. Teraz je presne 22:30
v noci a mam hlad.
424
00:29:22,600 –> 00:29:29,120
Je to dokopy asi len 25
hodin, co som naposledy nieco jedol
425
00:29:29,120 –> 00:29:35,360
a perspektiva toho ze pojdem do postele
zatial co som hladny mi nerobi vobec dobre.
426
00:29:36,960 –> 00:29:39,680
Myslim ze ma to dostava,
pretoze minulu noc som mal sen
427
00:29:39,680 –> 00:29:44,080
o tom ako som zjedol sendvic a
potom som sa citil hrozne previnilo.
428
00:29:44,080 –> 00:29:47,960
Bol to tak zivy sen, ze som sa po zobudeni obzeral
ci niesu nejake omrvinky na posteli,… ale bohuzial neboli.
429
00:29:47,960 –> 00:29:50,440
Myslim, ze je cas ist do prace.
430
00:29:53,480 –> 00:29:56,240
Jednoduche dietne opatrenia
431
00:29:56,240 –> 00:29:59,120
mozu naozaj zmenit ako
funguje ludske telo.
432
00:29:59,120 –> 00:30:01,600
Toto vas dava do vyssej rizikovej kategorie.
433
00:30:04,440 –> 00:30:08,920
Tak ako ma Valter varoval,
Prvy den bol naozaj tazky.
434
00:30:08,920 –> 00:30:11,520
Nie tak celkom, preto ze som mal hlad,
435
00:30:11,520 –> 00:30:15,880
ale jednoducho preto, ze som este nikdy
nic take predtym nerobil.
436
00:30:15,880 –> 00:30:18,880
Bol to strach z neznameho.
437
00:30:18,880 –> 00:30:22,720
Po zotmeni, zacinam mat dojem
ze to cele bol jeden velmi zly napad …
438
00:30:25,400 –> 00:30:28,280
.. zvlast, po tom, ako som
mal veceru s nasim filmovym stabom.
439
00:30:33,600 –> 00:30:36,120
Alebo lepsie povedane, po tom co oni mali veceru.
440
00:30:38,160 –> 00:30:41,720
Takze, ano, som v
krasnej starej korejskej restauracii
441
00:30:41,720 –> 00:30:45,200
s celou nasou posadkou.
442
00:30:45,200 –> 00:30:48,240
A ako vidite, v sucasnej dobe sa pekne napchavaju..
443
00:30:48,240 –> 00:30:50,440
Chuti vam, chlapci?
444
00:30:50,440 –> 00:30:51,680
Je to vyborne. Ano.
445
00:30:51,680 –> 00:30:56,560
Naozaj to dobre vonia. Naozaj,
ale naozaj by mi nevadilo trosku si zahryznut.
446
00:30:59,480 –> 00:31:02,080
Citim velky hlad.
447
00:31:03,760 –> 00:31:08,720
Nastastie, moja vecera uz
na mna caka v hotelovej izbe.
448
00:31:13,080 –> 00:31:15,880
Musel som odist, nemohol som
sa na to uz dlhsie divat.
449
00:31:22,360 –> 00:31:26,440
(Vzdych) Moja vynikajuca miso polievka je tu.
450
00:31:26,440 –> 00:31:29,280
Trosku si ju zamiesam hotelovym perom,
451
00:31:29,280 –> 00:31:31,680
pretoze som tu nenasiel ziadny pribor.
452
00:31:33,240 –> 00:31:34,960
Hmmmm!
453
00:31:36,280 –> 00:31:38,960
Zdravie. Celych jeho 25 kalorii.
454
00:31:38,960 –> 00:31:40,960
A jak sa na to tesim.
455
00:31:44,400 –> 00:31:46,440
Oh!
456
00:31:48,160 –> 00:31:52,160
OK, v konecne nejaka zmena v celom dni postu.
457
00:31:52,160 –> 00:31:54,440
Chutne ranajky, cierny caj.
458
00:31:54,440 –> 00:31:58,200
Citim sa trochu na omdletie
ale inak som vlastne v poriadku.
459
00:31:58,200 –> 00:32:00,160
Takze, uz je len 24 hodin predomnou
460
00:32:00,160 –> 00:32:03,440
a teraz uz som si isty
za to nejak dokazem vydrzat.
461
00:32:11,760 –> 00:32:15,120
Zistil som jednu vec, ze hlad
nenarasta umerne casu,
462
00:32:15,120 –> 00:32:16,880
ale prichadza vo vlnach, ktore vzdy prejdu.
463
00:32:18,200 –> 00:32:21,760
V tomto bode, uz moje telo vycerpalo
vsetky zasoby glukozy
464
00:32:21,760 –> 00:32:26,200
a presiel som na
spalovanie tukov ako hlavneho zdroja energie.
465
00:32:26,200 –> 00:32:27,960
A ak ma Valter pravdu,
466
00:32:27,960 –> 00:32:33,000
moja pecen by mala tiez
uz prestat vyrabat tolko IGF-1,
467
00:32:33,000 –> 00:32:36,040
a zaviest moje bunky do opravneho rezimu.
468
00:32:39,680 –> 00:32:44,600
Konecne, je 7 hodin rano, stvrty den,
Idem si dat spravit krvny test.
469
00:32:45,600 –> 00:32:49,440
Takze, po tomto, sa mozem ist
naranajkovat? Absolutne!
470
00:32:49,440 –> 00:32:51,560
Prve jedlo po
troch a pol dnoch,
471
00:32:51,560 –> 00:32:55,760
prve jedlo za 86 hodin.
No, kto by to pocital (?)
472
00:32:55,760 –> 00:32:58,640
Ja len dufam, ze
sa ukazu nejake zmeny,
473
00:32:58,640 –> 00:33:02,120
hlavne co sa tyka mojho IGF, pretoze
ak som stravil tri a pol dna
474
00:33:02,120 –> 00:33:05,440
az skoro styri dni nejedenim a
vysledky by boli uplne nulove,
475
00:33:05,440 –> 00:33:07,760
to by bolo pre mna velmi depresivne.
476
00:33:09,800 –> 00:33:13,360
Post sa skoncil.
477
00:33:13,360 –> 00:33:16,720
Mmm. Ah! To je velmi …
478
00:33:16,720 –> 00:33:19,400
Uplne citim ako sa mi zacinaju
vyplnat vsetky prazdne miesta.
479
00:33:19,400 –> 00:33:23,360
Vlasne som ani nebol az tak hrozne hladny
ked som sa dnes rano prebudil, ale …
480
00:33:25,840 –> 00:33:28,960
.. ked som zacal jest, az potom som
si uvedomit, co to bolo, co mi tak chybalo.
481
00:33:33,280 –> 00:33:37,800
Neskor popoludni, sa stretnem
s Valterom aby som zistil
482
00:33:37,800 –> 00:33:39,600
ci toto vsetko bolo na nieco dobre.
483
00:33:41,120 –> 00:33:44,960
Dnes rano som skoncil post, a
mal som zemiakovu kasu a slaninku
484
00:33:44,960 –> 00:33:47,600
a citim sa lepsie. Oh, velmi dobre.
485
00:33:47,600 –> 00:33:50,960
A budem sa citit este lepsie
ak sa ukaze, ze mam dobre vysledky.
486
00:33:50,960 –> 00:33:53,640
Ano, tak podme sa na ne pozriet.
487
00:33:53,640 –> 00:33:58,240
Takze, vas inzulin rastovy factor
jedna, cize IGF-1,… toto je bezna hodnota.
488
00:33:58,240 –> 00:34:01,640
Wow. Zlou spravou je, ze ste takmer
v hornej casti normalneho rozmedzia.
489
00:34:01,640 –> 00:34:03,760
Ale na americke normy,
ste na tom vcelku dobre.
490
00:34:03,760 –> 00:34:07,440
Nie najlepsie, ale tiez nie
uplne zle. Som ako priemerny American, ze?
491
00:34:07,440 –> 00:34:10,520
To je pravda, ano.
Ale dobra sprava je,
492
00:34:10,520 –> 00:34:13,880
ze vdaka hladovke, ste spadli
na takmer polovicnu hodnotu. Wow.
493
00:34:13,880 –> 00:34:16,480
To je vela, nie?
Ano. To je velky pokles.
494
00:34:16,480 –> 00:34:18,960
Je to velmi dramaticky pokles,
cize na hladovku reagujete velmi dobre.
495
00:34:18,960 –> 00:34:20,960
Musim povedat, toto bolo fascinujuce.
496
00:34:20,960 –> 00:34:25,400
Zazit to bolo velmi,
velmi … no, prekvapujuce.
497
00:34:25,400 –> 00:34:28,320
“Prekvapujuci vysledok
– A obrovska ulava.
498
00:34:28,320 –> 00:34:32,360
“Znizenie mojho IGF-1 by malo znizit
moje riziko niektorych druhov rakoviny,
499
00:34:32,360 –> 00:34:34,920
“Ako je rakovina prostaty,
ktoru mal aj moj otec.
500
00:34:34,920 –> 00:34:37,880
“Moja hladinu cukru v krvi mi tiez
klesla na zdravu uroven,
501
00:34:37,880 –> 00:34:39,760
, z coho som naozaj moc poteseny.”
502
00:34:40,960 –> 00:34:47,840
Vyzyvam Vas najst absolutne cokolvek co by za styri dni
dosiahlo podobne extremne metabolicke zmeny
503
00:34:47,840 –> 00:34:50,160
ako su tieto, nech to je naozaj cokolvek.
504
00:34:50,160 –> 00:34:52,800
Myslim, ze toto je uz teraz
velmi extremne! Ano.
505
00:34:52,800 –> 00:34:55,800
Ano, ale ak viete o niecom,
inom co mozete urobit,
506
00:34:55,800 –> 00:34:58,280
co vam neublizi
a bude mat vyhody,
507
00:34:58,280 –> 00:35:01,800
co sposobuju taketo
zmeny, rad by som o tom vedel. OK.
508
00:35:05,520 –> 00:35:08,280
Ale Valter hovori, ze ak neprejdem
509
00:35:08,280 –> 00:35:11,480
na nizko bielkovinovu,
viac vegetariansku dietu,
510
00:35:11,480 –> 00:35:14,080
ucinky nevydrzia.
511
00:35:16,040 –> 00:35:18,720
Budem musiet drzat post
aspon raz za kazdych par mesiacov,
512
00:35:18,720 –> 00:35:21,920
aby sa zachovali vyhody.
513
00:35:21,920 –> 00:35:25,560
Mozem skutocne vidiet sam seba nieco taketo robit?
514
00:35:25,560 –> 00:35:27,720
Musite urobit rozhodnutie
vo vasom pripade,
515
00:35:27,720 –> 00:35:29,240
vieco co chcete urobit?
516
00:35:29,240 –> 00:35:32,240
Je vela liekov
co by ste mohli uzivat,
517
00:35:32,240 –> 00:35:34,000
ale je to presne to, co chcete urobit?
518
00:35:34,000 –> 00:35:39,200
A ak tak urobite, za niekolko
rokov, alebo v niekolkych rokoch,
519
00:35:39,200 –> 00:35:43,080
budete
typickym 65-rocnym europanom
520
00:35:43,080 –> 00:35:47,120
co berie 8 roznych liekov
denne, a tak, aj to je vasa moznost.
521
00:35:47,120 –> 00:35:50,200
(MICHAEL sa smeje) A tak to je na Vas.
522
00:35:50,200 –> 00:35:54,320
Dakujem, OK! Tak to je
celkom zaujimava volba!
523
00:36:01,440 –> 00:36:04,360
To je naozaj, ale naozaj impozantne,
524
00:36:04,360 –> 00:36:06,400
ze len za
tri a pol dna,
525
00:36:06,400 –> 00:36:09,160
ak su tie vysledky spravne, a
ak su vysledky na zvieratach spravne,
526
00:36:09,160 –> 00:36:12,160
som si takto masivne znizil riziko
527
00:36:12,160 –> 00:36:16,280
celej rady
veku-pribuznych chorob.
528
00:36:16,280 –> 00:36:19,760
Velkou otazkou v mojej
mysli, v tomto okamihu je,
529
00:36:19,760 –> 00:36:22,960
mozem si spravit post raz do mesiac,
530
00:36:22,960 –> 00:36:25,920
dlhodobo, ci permanentne?
531
00:36:25,920 –> 00:36:28,200
Alebo je lepsia
moznost, odlisny sposob,
532
00:36:28,200 –> 00:36:30,200
a viac zvladnutelna cesta,
533
00:36:30,200 –> 00:36:33,640
, ktora moze pre mna spravit viac nez tato,
534
00:36:33,640 –> 00:36:37,360
a pripadne je este trochu viac bezbolestna?
535
00:36:37,360 –> 00:36:40,600
Na co som prisiel
o sebe samom je
536
00:36:40,600 –> 00:36:46,040
ze najvacsim problemom
dlhodobeho hladovania pre mna osobne, som ja sam.
537
00:36:48,480 –> 00:36:51,520
Valter: “Musite
urobit rozhodnutie teraz.
538
00:36:51,520 –> 00:36:52,880
“Hladovanie je tazke.”
539
00:36:55,160 –> 00:36:58,360
Hoci viem uz o vsetkych
uzasnych vyhodach …
540
00:37:00,480 –> 00:37:03,000
.. jednoducho sa nemozem prinutit to robit.
541
00:37:15,680 –> 00:37:18,920
Ale skvela vec na vede je
542
00:37:18,920 –> 00:37:22,720
, ze stale sa najde niekto
kto pracuje na dalsiom vyskume,
543
00:37:22,720 –> 00:37:25,280
v nadvaznosti na to, co dosiahli ini pred nim,
544
00:37:25,280 –> 00:37:28,720
co je dovodom, preco som dnes v Chicagu.
545
00:37:28,720 –> 00:37:33,320
Tu robia studie nie len
na mysiach, ale aj na cloveku.
546
00:37:37,200 –> 00:37:39,920
A zda sa, ze nasli sposob, ako
547
00:37:39,920 –> 00:37:43,520
spravit post trosku viac znesitelnym.
548
00:37:43,520 –> 00:37:48,440
Som tu aby som stretol Dr. Kristu Varadi,
549
00:37:48,440 –> 00:37:52,600
ktora skuma
nieco, co znie trosku jednoduchsie.
550
00:37:52,600 –> 00:37:54,400
Postit sa kazdy druhy den.
551
00:37:54,400 –> 00:37:57,040
Dobry den! Dobry den! Ahojte!
552
00:37:57,040 –> 00:38:00,560
Som rad, ze vas spoznavam.
Podobne! Volam sa Krista Varadi.
553
00:38:00,560 –> 00:38:02,360
Dobry den! Takze co je tou novinkou?
554
00:38:02,360 –> 00:38:04,400
Toto su niektore
komponenty, ktore pouzivame
555
00:38:04,400 –> 00:38:08,040
v diete pocas obden postu.
556
00:38:08,040 –> 00:38:11,560
V zaklade to je zalozene na dni
drastickeho znizenia prijmu kalorii.
557
00:38:11,560 –> 00:38:13,720
U zien, asi 400
az 500 kalorii,
558
00:38:13,720 –> 00:38:16,280
a u muzov, asi okolo 500
az 600 kalorii denne,
559
00:38:16,280 –> 00:38:18,760
a to len v jednom jedle
vzdy okolo obeda.
560
00:38:18,760 –> 00:38:22,040
Tomuto dnu hovorime, ze to je: postny den.
561
00:38:22,040 –> 00:38:24,560
Takze postny den nie je
o uplnej abstinencii.
562
00:38:24,560 –> 00:38:27,640
Je to o jedle, ktore vyzera asi takto.
563
00:38:27,640 –> 00:38:31,480
Co je skvele o kazdom druhom dni postu
564
00:38:31,480 –> 00:38:33,520
je to, co sa deje kazdy druhy den.
565
00:38:33,520 –> 00:38:36,920
A to je den, ktory nazyvame:
dnom neobmedzeneho jedenia,
566
00:38:36,920 –> 00:38:40,560
a to je teda den ked mozete jest cokolvek
chcete. Uplne vsetko co len chcete.
567
00:38:40,560 –> 00:38:44,680
Takze to je zalozene
cele na kazdom druhom dni postu.
568
00:38:44,680 –> 00:38:46,880
Postny den.
569
00:38:46,880 –> 00:38:47,960
Den jedenia.
570
00:38:47,960 –> 00:38:49,880
Postny den.
571
00:38:49,880 –> 00:38:51,320
Den jedenia.
572
00:38:51,320 –> 00:38:56,320
To iste znie jednoduchsie
ako dlhodoby post,
573
00:38:56,320 –> 00:38:59,120
alebo denne obmedzovanie
kalorii, na ktore som sa pozeral predtym.
574
00:38:59,120 –> 00:39:00,680
Ale je to aj tak ucinne?
575
00:39:00,680 –> 00:39:04,800
Momentalne Krista pracuje
na vyskume obeznych pacientov
576
00:39:04,800 –> 00:39:08,280
a vysledky naznacuju, ze tomu tak je.
577
00:39:08,280 –> 00:39:10,840
To, co sme videli, bolo, ze
skupina co drzala post kazdy druhy den
578
00:39:10,840 –> 00:39:12,960
stratila trochu viac vahy,
579
00:39:12,960 –> 00:39:16,360
tak asi o 2 kila viac na osobu
pocas 6-tich mesiacov.
580
00:39:16,360 –> 00:39:21,480
A to bola tiez skupina, kde sme pozorovali
velmi dobry pokles LDL cholesterolu,
581
00:39:21,480 –> 00:39:23,240
ako aj triglyceridov.
582
00:39:23,240 –> 00:39:26,160
LDL cholesterol, je
zly cholesterol,
583
00:39:26,160 –> 00:39:29,440
a triglyceridy
– v podstate ich vyssie mnozstvo,
584
00:39:29,440 –> 00:39:32,720
moze viest k ochoreniu srdca
a ochoreniam spojenym s vekom.
585
00:39:32,720 –> 00:39:36,280
Vidime tiez, naozaj pekne
znizenie krvneho tlaku
586
00:39:36,280 –> 00:39:37,840
pocas dlzky trvania tejto studie.
587
00:39:37,840 –> 00:39:42,040
Takze, vyznamne znizenie
rizikovych faktorov pre ochorenia srdca.
588
00:39:49,400 –> 00:39:51,800
“Navyse k doteraz
skor obmedzenym studiam na ludoch,
589
00:39:51,800 –> 00:39:55,160
je tu vela dobrych
dokazov zo studii na zvieratach
590
00:39:55,160 –> 00:39:58,600
, ktore su na tomto obden poste,
a ukazuju, ze je to nielen bezpecne ale aj ucinne.
591
00:40:00,320 –> 00:40:02,880
“Som tak presvedceny, ze to skusim.
592
00:40:02,880 –> 00:40:05,400
Vcera som sa postil.
593
00:40:05,400 –> 00:40:07,360
Dnes budem jest.”
594
00:40:07,360 –> 00:40:11,000
Takze dufajme, ze sa dokazem
vratit … nejak lahko.
595
00:40:11,000 –> 00:40:15,040
Ooh, magicky mysterizozny vylet!
To sa mi paci! Yeah, yeah!
596
00:40:15,040 –> 00:40:18,160
Hudba: “Johnny B Goode” od Chucka Berryho
597
00:40:27,120 –> 00:40:29,520
(ZVONEC) Ahoj, vdaka ze ste sa zastavili.
598
00:40:29,520 –> 00:40:31,360
Mozem vziat vasu objednavku, prosim?
599
00:40:31,360 –> 00:40:35,520
♪ Hlboko v Louisiane
V blizkosti New Orleans
600
00:40:35,520 –> 00:40:37,520
? Dalekov
lesoch medzi zelenacmi
601
00:40:37,520 –> 00:40:40,360
♪ Tam stalla kabinka
spravena zo zeminy a dreva
602
00:40:40,360 –> 00:40:42,800
? Tam zil
chlapec menom Johnny B. Goode. ?
603
00:40:42,800 –> 00:40:44,160
Velmi dobra volba!
604
00:40:44,160 –> 00:40:47,040
Obzvlast sa mi paci to mnozstvo
cohosi zeleneho vytrcajuceho z boku.
605
00:40:47,040 –> 00:40:48,600
Takze, musim priznat,
606
00:40:48,600 –> 00:40:52,440
som prekvapeny, ze som tu s vami.
607
00:40:52,440 –> 00:40:55,760
Tak nejako som si predstavoval, ze sa budete
drzat, no,
608
00:40:55,760 –> 00:40:58,080
viete, nejakej vegetarianskej diety
alebo takeho niecoho.
609
00:40:58,080 –> 00:41:00,760
Alebo, jest vela salatov
alebo niecoho take v dnoch ked sa moze jest, nie?
610
00:41:00,760 –> 00:41:04,920
Nie, vlastne je to tak, ze pokial sa budete drzat
toho, ze dosiahnete svoj kaloricky ciel v postnom dni,
611
00:41:04,920 –> 00:41:09,400
tak mozete doslova jest co
sa vam paci v tych dnoch ked sa je neobmedzene.
612
00:41:09,400 –> 00:41:13,680
“V jednej z najnovsich studii
Krista porovnavala dve skupiny na obden diete,
613
00:41:13,680 –> 00:41:16,560
“Jedna konzumovala jedla s vysokym, druha zase s nizkym obsahom tuku,
614
00:41:16,560 –> 00:41:18,960
pocaj dni jedenia.”
615
00:41:18,960 –> 00:41:21,120
Mne ide o moju hladinu glukozy v krvi,
616
00:41:21,120 –> 00:41:23,000
a tiez o moj cholesterol,
617
00:41:23,000 –> 00:41:25,440
A mam obavy o
vela inych veci. Ano, ano.
618
00:41:25,440 –> 00:41:29,240
Neovlyvnim teda nejako negativne toto vsetko
tym, ze budem jest jedla s vysokym obsahom tuku?
619
00:41:29,240 –> 00:41:31,320
To je vlastne to, co
sme si tiez mysleli, ze sa stane.
620
00:41:31,320 –> 00:41:32,640
Ale potom, prekvapujuco,
621
00:41:32,640 –> 00:41:35,000
zistili sme, ze vidime rovnaky pokles
LDL cholesterolu,
622
00:41:35,000 –> 00:41:36,880
to je ten zly cholesterol,
623
00:41:36,880 –> 00:41:38,600
a tiez triglyceridov,
624
00:41:38,600 –> 00:41:40,800
a krvneho tlaku.
625
00:41:40,800 –> 00:41:43,000
Takze, pokial ide o
riziko kardiovaskularnych ochoreni,
626
00:41:43,000 –> 00:41:45,600
nezalezalo na tom, ci ste
jedli jedlo s vysokym obsahom tuku alebo s nizkym obsahom tuku.
627
00:41:45,600 –> 00:41:50,200
Dalsim velkym prekvapenim bolo,
, ze po dni postu,
628
00:41:50,200 –> 00:41:54,280
sa ludia len zriedka prejedali
v dni kde mohli jest co len chceli.
629
00:41:57,680 –> 00:42:01,320
Takze, ked sme chceli aby ludia jedli len 25%
ich energetickych potrieb v ich postny den,
630
00:42:01,320 –> 00:42:03,880
tak sme si mysleli, ze ked
rozbehneme tuto studiu,
631
00:42:03,880 –> 00:42:05,920
ze ludia budu jest 175% na druhy den.
632
00:42:05,920 –> 00:42:09,120
Ale hned od
zaciatku, bez ohladu na okolnosti,
633
00:42:09,120 –> 00:42:13,840
ludia jednoducho nedokazali zjest
o 175% viac na dalsi den po poste.
634
00:42:13,840 –> 00:42:16,320
Vacsina ludi jedla v priemere len okolo 110%.
635
00:42:16,320 –> 00:42:18,880
Takze len nieco malo naviac nez
zvycajne jedavaju normalne.
636
00:42:18,880 –> 00:42:21,320
Z vysledkov sa zda ze tempo
procesu starnutia sa ale spomalilo,
637
00:42:21,320 –> 00:42:23,000
a tiez choroby s tym spojene.
638
00:42:23,000 –> 00:42:25,600
Znizuje to riziko
pridruzenych ochoreni,
639
00:42:25,600 –> 00:42:28,120
co je neuveritelna
vec. Ano, absolutne.
640
00:42:33,640 –> 00:42:37,200
Kristin vyskum je
stale v pociatocnych fazach.
641
00:42:37,200 –> 00:42:40,360
Ale z toho, co som videl a zazil,
642
00:42:40,360 –> 00:42:42,520
mam pocit, ze nadomnou uz vitazi
643
00:42:42,520 –> 00:42:45,360
myslienka, ze jednoduchy vzorec
644
00:42:45,360 –> 00:42:49,040
striedania postu s jedenim, moze byt velmi silnym liekom.
645
00:42:49,040 –> 00:42:54,000
Zda sa, ze to moze mat vplyvy, ktore
presahuju jednoducho to ze clovek je menej konzumuje.
646
00:42:54,000 –> 00:42:57,240
A myslim, ze toto by mohlo
fungovat pre niekoho ako som ja.
647
00:43:03,080 –> 00:43:05,920
Moja posledna zastavka je v Baltimore.
648
00:43:05,920 –> 00:43:09,520
Som tu, pretoze potrebujem
posledny kusok motivacie.
649
00:43:12,560 –> 00:43:17,240
Je tu jeden aspekt starnutia
ktory je pre mna najviac desivy, viac nez akykolvek iny.
650
00:43:17,240 –> 00:43:21,320
Ucinky starnutia prejavujuce sa na mojom mozgu.
651
00:43:24,280 –> 00:43:27,440
Snazim sa dohnat
profesora Marka Mattsona.
652
00:43:27,440 –> 00:43:31,840
Mark je poprednym odbornikom
na starnutie mozgu.
653
00:43:31,840 –> 00:43:34,960
Jeho vyskumy naznacuju, ze post
654
00:43:34,960 –> 00:43:37,800
moze pomoct oddialit nastup ochorenia
655
00:43:37,800 –> 00:43:40,520
ako je napriklad Alzheimerova choroba,
demencia, a strata pamati.
656
00:43:40,520 –> 00:43:41,680
Velmi dobre! A ako sa mate vy?
657
00:43:41,680 –> 00:43:44,560
Ahoj! Michael Mosley. Mark Mattson.
658
00:43:44,560 –> 00:43:47,520
Vy tu pracujete? Pracovat tu? Nie!
659
00:43:47,520 –> 00:43:50,840
Tiez nepracujem
tu! (MICHAEL sa zasmial).
660
00:43:50,840 –> 00:43:54,800
OK, Michael. Potrebujeme
aby ste si tu obuli topanky!
661
00:43:56,520 –> 00:43:59,880
Mierime dolu do suterenu
662
00:43:59,880 –> 00:44:03,080
Narodneho Institutu pre Vyskum Starnutia.
663
00:44:03,080 –> 00:44:04,280
OK? Ano.
664
00:44:04,280 –> 00:44:06,000
Schovana tu dole,
665
00:44:06,000 –> 00:44:09,720
je jedna specialna mys
ktoru mi chce ukazat.
666
00:44:17,680 –> 00:44:20,400
Tato mys preskumava bludisko.
667
00:44:22,800 –> 00:44:25,680
Je to test pamate, vytvoreny tak
aby sme videli, ako dobre si mys zapamata
668
00:44:25,680 –> 00:44:28,840
kde nasla predtym jedlo.
669
00:44:28,840 –> 00:44:32,000
Takze jedlo je skutocne v
bludisku, ano? Jedlo je tu.
670
00:44:32,000 –> 00:44:35,920
Mysi, ktore studuju, su modifikovane
tak aby sa u nich rozvinula Alzheimerova choroba.
671
00:44:38,440 –> 00:44:41,560
Normalne tejto chorobe podlahnu v ramci
pomerne kratkej doby,
672
00:44:41,560 –> 00:44:44,360
ale ked su tieto mysi na obden diete pozostavajucej
673
00:44:44,360 –> 00:44:47,160
z postnych dni a dni jedenia,
674
00:44:47,160 –> 00:44:50,120
co Mark nazyva “prerusovanym
dnom obmedzenia energie”,
675
00:44:50,120 –> 00:44:51,840
vysledky su uplne neuveritelne.
676
00:44:51,840 –> 00:44:55,680
.. a to take, ze zvierata na
prerusovanom energetickom obmedzeni,
677
00:44:55,680 –> 00:44:58,240
ziju ovela dlhsie normalnym zivotom,
678
00:44:58,240 –> 00:44:59,880
aspon, z toho co zatial dokazeme testovat,
679
00:44:59,880 –> 00:45:03,560
cize normalne sa ucia a normalne si pamataju,
, nez zacnu mat nejake problemy.
680
00:45:03,560 –> 00:45:05,280
Vyrazne dlhsie?
681
00:45:05,280 –> 00:45:07,480
Ano, velmi vyrazne.
682
00:45:07,480 –> 00:45:10,600
V jednej studii,
sa ukazalo ze to je medzi sest mesiacov az jeden rok dlhsie.
683
00:45:10,600 –> 00:45:14,280
To by bol ekvivalent
u cloveka s
684
00:45:14,280 –> 00:45:17,280
rozvojovymi znamkami Alzheimerovej choroby,
ci dostane chorobu vo veku 50,
685
00:45:17,280 –> 00:45:20,760
alebo az vo veku 80-tich rokov? Tak
zhruba? Je to pravda? Ano.
686
00:45:20,760 –> 00:45:24,160
“Na druhej strane, ked
mysi jedli zlu stravu,
687
00:45:24,160 –> 00:45:27,640
ide to s nimi dole vodou rychlo.”
688
00:45:27,640 –> 00:45:30,920
Davame im… Vela sladkych
napojov? A dietu s vysokym obsahom tukov, presne.
689
00:45:30,920 –> 00:45:32,880
A tiez im pridavame fruktozu
do ich pitnej vody,
690
00:45:32,880 –> 00:45:35,520
a to ma uplne dramaticky ucinok.
691
00:45:35,520 –> 00:45:37,920
Tieto zvierata maju este skorsi nastup choroby
692
00:45:37,920 –> 00:45:40,280
a problem s ucenim a pamatou.
693
00:45:40,280 –> 00:45:41,720
Je to ovela skor?
694
00:45:41,720 –> 00:45:44,880
Tak zhruba uz v styroch mesiacoch. Wow.
695
00:45:44,880 –> 00:45:48,760
Takze to je ekvivalent
vzniku Alzheimerovej choroby
696
00:45:48,760 –> 00:45:51,360
uz po 30tke, tesne pred 40tim rokom u cloveka? Presne!
697
00:45:51,360 –> 00:45:55,120
Zatial, sa robili len
studie na mysiach,
698
00:45:55,120 –> 00:45:58,040
ale uz sa planuje
testovanie aj na ludoch.
699
00:45:58,040 –> 00:46:00,400
Ake su dokazy
ze ak by niekto som ja
700
00:46:00,400 –> 00:46:02,520
zacal prerusovane hladovanie,
701
00:46:02,520 –> 00:46:05,520
ze by to znizilo jeho riziko
ochorenia mozgu, zhruba?
702
00:46:07,640 –> 00:46:10,000
Myslim, ze z ludskeho hladiska,
703
00:46:10,000 –> 00:46:16,000
ak pojdeme na stupnici od
zlej pravdepodobnosti az k velmi dobrej,
704
00:46:16,000 –> 00:46:18,080
a od vybornej az k vynikajucej,
705
00:46:18,080 –> 00:46:20,400
bolo by to niekde medzi velmi dobrou
az vynikajucou pravdepodobnostou.
706
00:46:21,760 –> 00:46:24,720
To je sposob, akym by som to kategorizoval ja.
707
00:46:29,560 –> 00:46:31,320
Ale, ako to vlastne funguje?
708
00:46:33,440 –> 00:46:36,120
No, ked sme skumali
mozgove tkanivo mysi na poste,
709
00:46:36,120 –> 00:46:39,440
nasli sme nieco uplne mimoriadne.
710
00:46:39,440 –> 00:46:44,920
Tieto zelene objekty
su novonarodene mozgove bunky.
711
00:46:44,920 –> 00:46:47,080
Tieto tri tu su uplne nove?
712
00:46:47,080 –> 00:46:53,600
Zda sa ze sporadicke hladovky
sposobuju vznik novych neuronov.
713
00:46:53,600 –> 00:46:57,160
Preco by mozog zacal vytvarat
714
00:46:57,160 –> 00:47:00,000
nove nervove bunky, ked
mu prestaneme davat jedlo?
715
00:47:00,000 –> 00:47:03,240
No, ak nad tym uvazujete
z evolucneho hladiska, dava zmysel,
716
00:47:03,240 –> 00:47:09,040
ze ak mate hlad, treba radsej
zvysit kognitivne schopnosti.
717
00:47:09,040 –> 00:47:11,280
Tie vam daju najlepsiu sancu na prezitie, je vyhoda,
718
00:47:11,280 –> 00:47:15,000
ak si ho pamatate, kde
ste naposledy videli alebo schovali potravu, atd.
719
00:47:17,040 –> 00:47:22,760
Zda sa, ze post cvici sedu mozgovu koru
podobne, ako cvicenie cvici svaly.
720
00:47:25,480 –> 00:47:30,160
Takze hlad vas robi
bystrejsim, mudrejsimi? Ano. Myslime si, ze ano.
721
00:47:34,080 –> 00:47:39,280
Markov vyskum vedie
k jednoduchemu uzaveru.
722
00:47:39,280 –> 00:47:43,600
Drzanie postu kazdy druhy den ma
lepsie ucinky na mozog
723
00:47:43,600 –> 00:47:47,480
nez keby clovek len celkovo
znizil prijem dennych kalorii.
724
00:47:47,480 –> 00:47:53,280
Je to pravda na mysiach, ale potrebujeme
lepsie studie, aby sme dokazali, ze sa to tyka aj ludi.
725
00:47:57,840 –> 00:48:02,000
Prisiel som na koniec mojho hladania ako
zistit co jest, ako sa postit a zit tak dlhsie.
726
00:48:03,200 –> 00:48:07,600
Oficialna rada je, jest
aspon 2,000 kalorii denne,
727
00:48:07,600 –> 00:48:11,640
ale ak naozaj chcete skusit post,
dokonca co len na striedavom zaklade,
728
00:48:11,640 –> 00:48:15,920
chodte najprv k doktorovi,
lebo su ludia, ktorym by to mohlo ublizit,
729
00:48:15,920 –> 00:48:19,560
ako su napriklad tehotne zeny alebo,
ludia trpiaci pod-vahou.
730
00:48:21,200 –> 00:48:25,960
Ja budem opatrny, a rozhodol som sa
ze skusim vzor, ktory mi odporucil Mark.
731
00:48:25,960 –> 00:48:31,680
Nie kazdy druhy den post, ale
menej extremnu verziu 5+2 dietu –
732
00:48:31,680 –> 00:48:37,080
cize mozem jest 5 dni, co bude nasledovane
dvoma dnami postu, a toto robit kazdy tyzden.
733
00:48:38,360 –> 00:48:43,720
Dnes je moj posledny den v Spojenych statoch, a
uplne mi to otvorilo oci.
734
00:48:43,720 –> 00:48:48,480
Nemal som tusenie, ze vobec existovalo
tolko vyskumu na temu
735
00:48:48,480 –> 00:48:54,200
postu, kalorickeho obmedzovania, vo vsetkych
takychto formach, a celkovo tolko vyskumu o starnuti.
736
00:48:55,200 –> 00:48:59,960
Rozhodol som sa ale, ze sa rozhodne
pokusim drzat mojho 5+2 programu,
737
00:48:59,960 –> 00:49:05,200
ako vravim, je to pat dni jedenia,
a potom dva dni na 600 kaloriach denne.
738
00:49:05,200 –> 00:49:07,760
Naozaj, naozaj dufam, ze
to pre mna spravi nejaky rozdiel,
739
00:49:07,760 –> 00:49:11,360
pretoze som si vedomy, ze uz teraz
som naozaj na konci zrazu
740
00:49:11,360 –> 00:49:14,720
ktory je mojou vstupenkov
k velmi strmemu vstupu do staroby,
741
00:49:14,720 –> 00:49:19,560
a teda ak je nieco, co moze
spomalit proces starnutia a dat mi
742
00:49:19,560 –> 00:49:25,360
viac rokov zdraveho zivota,
potom by som to naozaj rad vyskusal.
743
00:49:31,000 –> 00:49:35,280
Idem domov do Velkej Britanie.
744
00:49:35,280 –> 00:49:40,560
Rozhodol som sa, ze si dam pat
tyzdnov na to aby som si zvykol na moju novu dietu,
745
00:49:40,560 –> 00:49:43,760
a uvidime, ci dosiahnem nejake vysledky.
746
00:49:49,760 –> 00:49:52,520
To je
jeden z mojich postnych dni,
747
00:49:52,520 –> 00:49:55,240
a rozhodol som sa, ze
ranajky budu mojim hlavnym jedlom dna.
748
00:49:55,240 –> 00:49:59,440
Aj ked teda Mark Mattson povedal, ze
si nemysli, ze zalezi na tom
749
00:49:59,440 –> 00:50:01,760
kedy clovek zje nadelene
kalorie v jeho postnom dni.
750
00:50:01,760 –> 00:50:05,280
Snazil som sa rozne veci, ale
pre mna je to doslova znicujuce
751
00:50:05,280 –> 00:50:07,840
ist do prace, ked
mam hlad.
752
00:50:09,640 –> 00:50:12,480
Je tu dalsi dovod, preco som
rozhodol sa vyskusat tento rezim.
753
00:50:12,480 –> 00:50:16,040
Ked som prisiel domov, dal som si
spravit dalsi IGF-1 test.
754
00:50:17,040 –> 00:50:21,280
Bohuzial, moja uroven
bola zase vysoka, ako aj predtym.
755
00:50:21,280 –> 00:50:27,800
Ukazalo sa, ze tazko ziskane ucinky
stvordnoveho postu, trvali len velmi kratku chvilu.
756
00:50:27,800 –> 00:50:30,680
Aj ona si uz na to zvykla,
v tejto chvili, aspon myslim…
757
00:50:30,680 –> 00:50:33,920
Takze dufam, ze je to
nieco, co uz dokazem vydrzat. ”
758
00:50:33,920 –> 00:50:37,280
Dobre. Je to v pohode. Je
dvadsat minut do dvoch,
759
00:50:37,280 –> 00:50:41,040
a necitim sa ani trochu hladny
, ale je cas obeda,
760
00:50:41,040 –> 00:50:44,920
takze ked uz nic ine, myslim, ze
sa pojdem aspon prejst.
761
00:50:44,920 –> 00:50:50,680
HUDBA: “Harder, Better,
Rychlejsie, silnejsie” od Daft Punk
762
00:51:02,400 –> 00:51:06,840
Zistil som, ze postne dni
ked mam vela prace v robote, znasam lahsie,
763
00:51:06,840 –> 00:51:09,720
ale mojim velkym testom bude dovolenka.
764
00:51:09,720 –> 00:51:11,880
Prechadzam sa s priatelmi.
765
00:51:11,880 –> 00:51:17,080
Robime prechod cez
Trans-Pennine Way.
766
00:51:17,080 –> 00:51:22,080
Mal som ranajky toto rano
asi pred dvoma hodinami,
767
00:51:22,080 –> 00:51:28,200
a dalsi plan jest
je az na ranajky zajtra rano.
768
00:51:28,200 –> 00:51:32,160
Zatial sa citim celkom dobre.
769
00:51:35,080 –> 00:51:39,960
Teraz je asi 7 hodin.
Nejedol som nic uz 12 hodin.
770
00:51:39,960 –> 00:51:43,520
Ostatny su za mnou
a jedia v tejto krcmicke,
771
00:51:43,520 –> 00:51:47,640
tak som sa rozhodol ist
vonku na chvilku, pretoze …
772
00:51:47,640 –> 00:51:50,400
nie som taky silny, ako
som si myslel ze budem.
773
00:51:50,400 –> 00:51:53,480
Moj zaludok zacina pracovat
, ale to je v poriadku.
774
00:51:57,880 –> 00:52:02,400
“Je to uz pat tyzdnov od
co som zacal 5+2 dietu.”
775
00:52:02,400 –> 00:52:04,720
K nohe! K nohe!
776
00:52:04,720 –> 00:52:06,920
Toto je teda za psa!
777
00:52:06,920 –> 00:52:10,520
“Podarilo sa mi zmestit do dvoch 600
kaloriovych dni v tyzdni,
778
00:52:10,520 –> 00:52:13,960
“Hoci myslim ze by som inklinoval
k tomu aby boli tie postne dni trosku viac od seba.
779
00:52:13,960 –> 00:52:16,440
Ale bolo toto vsetko dost na to
aby to spravilo rozdiel? ”
780
00:52:17,840 –> 00:52:19,640
Dnes je den, ked uvidim svoje vysledky.
781
00:52:19,640 –> 00:52:21,520
Stratil som, co vidim, nejaku tu vahu,
782
00:52:21,520 –> 00:52:25,000
Zistim za okamih presne
kolko vahy, ale co ma najviac zaujima
783
00:52:25,000 –> 00:52:29,200
su krvne vysledky, pretoze vysledky z 5-6
tyzdnov dozadu boli vcelku hrozne.
784
00:52:29,200 –> 00:52:34,280
Mam vysoku glukozu,
vysoky cholesterol, a vysoku hladinu IGF.
785
00:52:34,280 –> 00:52:37,480
A tak sa uz naozaj, ale naozaj
neviem dockat, aby som videl ci sa nieco zlepsilo,
786
00:52:37,480 –> 00:52:41,400
pretoze aby som bol uprimny, ak sa to
nezlepsilo, mam na ruke dost velky problem,
787
00:52:41,400 –> 00:52:46,480
ja totiz chcem zostat mlady a
zdravy pre moju rodinu, ale aj pre seba.
788
00:52:46,480 –> 00:52:51,800
A tak som celkom nervozny, pretoze
mi na tom strasne moc zalezi.
789
00:52:55,000 –> 00:52:59,080
Len pre pripomenutie, toto je ako som
vyzeral na zaciatku tohto filmu.
790
00:53:01,160 –> 00:53:04,040
A takto vyzeram dnes.
791
00:53:04,040 –> 00:53:06,640
Musel som si pridat niekolko
novych dierok na opasok,
792
00:53:06,640 –> 00:53:09,800
takze viem, ze sa nieco
zmenilo, ale ako a o kolko?
793
00:53:09,800 –> 00:53:14,400
Jasne, a je tu okamih pravdy, v ktorom som
zistil, kolko vahy som vlastne stratil.
794
00:53:14,400 –> 00:53:18,360
Toto je specialny druh vahy ktory
zmeria moju vahu velmi presne,
795
00:53:18,360 –> 00:53:20,280
a tiez zisti kolko ma moje telo tuku.
796
00:53:20,280 –> 00:53:23,280
Hey! Tak to je fantasticke!
797
00:53:23,280 –> 00:53:31,240
To je 78kg, co znamena, ze
som stratil skoro 6.5 kila.
798
00:53:31,240 –> 00:53:36,280
Moje telesny tuk, ked som
zacal bol na 27%,
799
00:53:36,280 –> 00:53:39,440
a teraz je to menej ako 20.
800
00:53:39,440 –> 00:53:42,560
To je naozaj, ale naozaj potesujuce.
801
00:53:46,280 –> 00:53:50,960
Citim sa dobre, a
rodina hovori ze vyzeram chudsie.
802
00:53:50,960 –> 00:53:54,120
A naozaj to nebolo tak tazke,
803
00:53:54,120 –> 00:53:58,280
a som rad, ze som uz opat v
normalnej vahovej kategorii.
804
00:53:58,280 –> 00:54:02,400
Ale to, co naozaj chcem vediet
je to, co sa zmenilo vo vnutri mojho tela.
805
00:54:06,920 –> 00:54:12,280
Profesor Luigi Fontana mi akurat
ide zavolat so svojimi konecnymi vysledkami.
806
00:54:12,280 –> 00:54:15,160
Ahoj, Michael! Ahoj, Luigi, ako sa mas?
807
00:54:15,160 –> 00:54:17,680
Som v poriadku, a ty? Mam sa velmi dobre.
808
00:54:17,680 –> 00:54:19,200
Takze, mame tvoje vysledky.
809
00:54:19,200 –> 00:54:23,880
Len tym ze si sa postil 2 dni do
tyzna, si spravil nieco uzasne
810
00:54:23,880 –> 00:54:28,760
pre tvoje kardio-metabolicke zdravie,
a tak som na teba velmi hrdy.
811
00:54:28,760 –> 00:54:33,920
‘Ale co sa stalo s mojim IGF-1?
Je moje telo este stale v rychlo-rychlo mode?’
812
00:54:33,920 –> 00:54:38,760
IGF-1 je hlavnym
rizikovym faktorom pre rakovinu.
813
00:54:38,760 –> 00:54:42,080
Rakovina prsnika, rakovina prostaty
, rakovina hrubeho creva.
814
00:54:42,080 –> 00:54:45,480
Obidva, tri a pol
dnovy post
815
00:54:45,480 –> 00:54:51,840
a tiez post zlozeny z piatich tyzdnov prerusovanej
hladovky Vam sposobil celkovy pokles IGF-1 o 50%.
816
00:54:53,360 –> 00:54:56,600
“Co je dostatocne k obmedzeniu
rizik viacerych druhov rakoviny.
817
00:54:56,600 –> 00:55:00,240
“Ale co moja hladina cukru v krvi,
ktora hranicila s cukrovkou? ”
818
00:55:00,240 –> 00:55:05,560
Vasa glukoza klesla
na 90. Tak veru. Fantasticke.
819
00:55:05,560 –> 00:55:07,640
Takze vasa glukozy je na normale.
820
00:55:07,640 –> 00:55:10,760
“Moj konecny vysledok je cholesterol.”
821
00:55:10,760 –> 00:55:15,320
Takze, tu ste mali znizenie
celkoveho cholesterolu,
822
00:55:15,320 –> 00:55:17,840
a zvysil sa vam
dobry cholesterol.
823
00:55:17,840 –> 00:55:21,920
To ukazuje, ako kratko
to trva, vidite,
824
00:55:21,920 –> 00:55:26,160
dojst k celkovemu zlepseniu a to bez drog,
a bez uzivania liekov.
825
00:55:26,160 –> 00:55:29,120
“Nebolo to bez usilia,
826
00:55:29,120 –> 00:55:34,520
ale znizil som riziko vzniku
chorob, ktore by mi mohli skratit zivot. ”
827
00:55:34,520 –> 00:55:37,680
Dakujem. Takze, by som mal zit
zdravo a stastne az do smrti, ze?
828
00:55:37,680 –> 00:55:40,200
Neviem ci budete zit
stastnejsie,
829
00:55:40,200 –> 00:55:44,200
ale mate nizsie riziko
toho ze sa u vas rozvinie nejake ochorenie.
830
00:55:44,200 –> 00:55:47,440
Velmi vam dakujem, Luigi,
Naozaj, dakujem. Nie je zac.
831
00:55:47,440 –> 00:55:50,600
Som velmi, velmi spokojny.
Velmi spokojny naozaj.
832
00:55:50,600 –> 00:55:53,920
To bolo ovela lepsie
nez som ocakaval.
833
00:55:55,400 –> 00:56:00,520
‘Chcel som aby moja zena Claire, ktora
je tiez doktorkou, videla moje vysledky.’
834
00:56:00,520 –> 00:56:05,840
Takze, toto je moje IGF, ktory je
rizikom pre rakovinu a vznik inych chorob.
835
00:56:05,840 –> 00:56:10,440
Toto zislo dole na polovicu
len mojim dvojdnovym postenim. Ano.
836
00:56:10,440 –> 00:56:14,560
Vsetko ukazuje zlepsenie
v ktore si dufal.
837
00:56:14,560 –> 00:56:15,720
Ano.
838
00:56:15,720 –> 00:56:19,040
To v podstate znamena, ze nebudem
musiet brat ziadne tablety, aspon v sucasnej dobe.
839
00:56:19,040 –> 00:56:20,280
Nie. Ale iba ak vydrzis svoj postny plan.
840
00:56:21,400 –> 00:56:24,080
No, vyzeras ale, ze ti velmi prospieva.
841
00:56:24,080 –> 00:56:26,160
Dakujem. Som naozaj spokojny.
842
00:56:26,160 –> 00:56:28,960
Musim povedat, ze to su naozaj,
uzasne dobre spravy. Hm.
843
00:56:33,400 –> 00:56:37,840
Vysledky boli
absolutne fantasticke pre mna sameho,
844
00:56:37,840 –> 00:56:42,000
ale, neznamena to, ze prerusovany
post bude pracovat pre kazdeho.
845
00:56:44,200 –> 00:56:48,200
Je naozaj dolezite, aby
sa urobilo viac studii na ludoch,
846
00:56:48,200 –> 00:56:51,320
a zistilo, ci je toto dlhodobo
bezpecne a efektivne.
847
00:56:53,760 –> 00:56:58,760
Ale tym ze som zazil prerusovany
post, mam v plane v nom pokracovat.
848
00:56:59,880 –> 00:57:03,240
Zda sa, ze to opravilo
niektore skody
849
00:57:03,240 –> 00:57:05,880
ktore som svojmu
telu sposobil za tie roky.
850
00:57:08,920 –> 00:57:12,040
Je velmi dojemne sa pozerat
na fotografie seba
851
00:57:12,040 –> 00:57:15,160
a clenov mojej rodiny
ako casom rastieme a starneme,
852
00:57:15,160 –> 00:57:18,640
ale neznamena to, ze
chcem zadrzat tok casu.
853
00:57:18,640 –> 00:57:23,920
Tak nejako viem ze starneme
a mali by sme zostarnut,
854
00:57:23,920 –> 00:57:26,920
a ze je len velmi malo co
s tym mozeme urobit.
855
00:57:26,920 –> 00:57:31,680
Ale post je trosku ina vec. Post
nie je o snahe zit do 140-tich rokov,
856
00:57:31,680 –> 00:57:35,880
Je to o tom zostat zdravy
tak dlho, ako je to len mozne,
857
00:57:35,880 –> 00:57:39,280
a momentalna doba,
ktorej celime ako narod,
858
00:57:39,280 –> 00:57:42,240
ked zapasime s obezitou
a je tu coraz viac cukrovkarov,
859
00:57:42,240 –> 00:57:45,960
zufalo potrebuje nieco
co moze spravit rozdiel.
860
00:57:45,960 –> 00:57:49,480
Post je prva vec
s ktorou som sa oboznamil
861
00:57:49,480 –> 00:57:52,840
o ktorej som skutocne presvedceny, ze
keby to ludia vyskusali, dali tomu sancu,
862
00:57:52,840 –> 00:57:56,840
mohlo by to radikalne zmenit
nase celo-narodne zdravie.
863
00:57:56,840 –> 00:58:03,360
Takze, dufam, ze budeme aj nadalej pokracovat
v masivnom vyskume a prieskume tohoto uzemia.
864
00:58:04,560 –> 00:58:08,240
Robit tento post
bola jedna z najzaujimavejsich veci …
865
00:58:08,240 –> 00:58:11,600
no, povedal by som, absolutne
naj-zaujimavejsia cesta na ktoru som sa podujal, ci filmoval,
866
00:58:11,600 –> 00:58:14,240
alebo ako to len chcete nazvat
,… cesta ktorej som sa zucastnil.
867
00:58:14,240 –> 00:58:16,320
(Pes knuci)
868
00:58:16,320 –> 00:58:18,520
A nieco take som nikdy predtym este nepovedal.
869
00:58:32,000 –> 00:58:35,640
Slovenske Titulky: Jozef Jarosciak ml.
——–
——–
Anglicke Titulky:
1
00:00:07,040 –> 00:00:09,000
I love life,
2
00:00:09,000 –> 00:00:13,280
so I want to remain young, energetic,
enjoy it for as long as I can.
3
00:00:13,280 –> 00:00:15,480
I’m medically trained.
4
00:00:15,480 –> 00:00:19,360
I know all the standard
advice for staying healthy.
5
00:00:19,360 –> 00:00:23,120
But in my case, it
doesn’t seem to be working.
6
00:00:24,760 –> 00:00:29,800
I’ve discovered that my body is
not the lean, long-lived machine
7
00:00:29,800 –> 00:00:31,800
I would like it to be.
8
00:00:31,800 –> 00:00:37,480
A third of your body is fat. Thank
you…for making that point so emphatically.
9
00:00:37,480 –> 00:00:42,400
I wanted to see if science can offer
a different way to stop the rot,
10
00:00:42,400 –> 00:00:44,560
slow the clock,
11
00:00:44,560 –> 00:00:48,000
so I set off to find experts
12
00:00:48,000 –> 00:00:51,520
who are trying to combat
the ravages of ageing.
13
00:00:51,520 –> 00:00:54,760
We are rewriting human
physiology here. Ooh…yay!
14
00:00:56,160 –> 00:01:00,440
If you can find something else that you can
do that it doesn’t hurt you, that benefits you
15
00:01:00,440 –> 00:01:03,440
and that causes these
changes, I’d like to know.
16
00:01:05,160 –> 00:01:08,200
What I discovered was truly surprising.
17
00:01:09,800 –> 00:01:14,640
It involves no pills, no
injections and no hidden cost.
18
00:01:14,640 –> 00:01:17,400
It’s all a question of what you eat.
19
00:01:17,400 –> 00:01:19,400
Or rather, what you don’t eat.
20
00:01:20,920 –> 00:01:25,480
Last night, I dreamt I ate a sandwich
and then I felt fantastically guilty.
21
00:01:25,480 –> 00:01:26,840
It’s about fasting.
22
00:01:26,840 –> 00:01:30,120
But fasting made easier.
23
00:01:30,120 –> 00:01:32,400
If I were to go onto Joe’s lifestyle…?
24
00:01:32,400 –> 00:01:36,200
In a year, you are going to be cured.
25
00:01:42,480 –> 00:01:48,600
The big thing is that this is the beginning
of something which I think could be huge.
26
00:01:48,600 –> 00:01:51,480
If it takes off and if it heads off
in the direction I imagine it will,
27
00:01:51,480 –> 00:01:54,920
then this…this could be
genuinely revolutionary.
28
00:02:10,840 –> 00:02:12,720
KLAXON
29
00:02:18,520 –> 00:02:23,160
There are plenty of people
who stay young and fit
30
00:02:23,160 –> 00:02:25,160
well beyond retirement age.
31
00:02:33,480 –> 00:02:36,320
They mainly do it the traditional way –
32
00:02:36,320 –> 00:02:39,120
through lots and lots of exercise.
33
00:02:39,120 –> 00:02:42,280
Today, I’ve come to the London Marathon.
34
00:02:42,280 –> 00:02:47,000
Nearly 36,000 bodies
of all shapes and sizes
35
00:02:47,000 –> 00:02:49,360
are tackling the 26-mile course.
36
00:02:49,360 –> 00:02:51,480
Some are young,
37
00:02:51,480 –> 00:02:53,400
many not so young.
38
00:03:00,560 –> 00:03:03,920
There’s an absolutely
fantastic atmosphere here.
39
00:03:03,920 –> 00:03:05,760
Now, I have never run the marathon
40
00:03:05,760 –> 00:03:08,560
and I have no plans to
ever run the marathon,
41
00:03:08,560 –> 00:03:12,160
but there are plenty
of people running today
42
00:03:12,160 –> 00:03:15,160
who are far older than me.
43
00:03:15,160 –> 00:03:18,880
There are 7,000 people in their 50s
44
00:03:18,880 –> 00:03:21,480
and, incredibly enough,
45
00:03:21,480 –> 00:03:25,560
there are seven people who
are in their 80s or older.
46
00:03:31,320 –> 00:03:35,280
I’m going to trying and
flag a few of them down
47
00:03:35,280 –> 00:03:37,200
to ask how they do it.
48
00:03:37,200 –> 00:03:39,560
Hello! How are you? Hello!
49
00:03:40,760 –> 00:03:42,720
How old are you? 78.
50
00:03:42,720 –> 00:03:44,360
And how old are you? 81.
51
00:03:50,960 –> 00:03:54,280
What’s the secret, then,
running? Magic wand!
52
00:03:54,280 –> 00:03:57,520
Just eating well. Hard
work son, that’s all!
53
00:03:59,120 –> 00:04:04,200
Anyone who can run a marathon
in their 70s deserves my respect,
54
00:04:04,200 –> 00:04:10,000
but I’m waiting for a man who
makes septuagenarians look youthful.
55
00:04:13,920 –> 00:04:16,440
Fauja Singh is amazing.
56
00:04:16,440 –> 00:04:19,120
He has been active all his life,
57
00:04:19,120 –> 00:04:22,800
but he only took up
serious running in his 80s.
58
00:04:22,800 –> 00:04:27,640
So what is it that keeps him
so remarkably fit and energetic?
59
00:04:27,640 –> 00:04:31,200
Hi, there. Nice to see you.
60
00:04:31,200 –> 00:04:34,080
How old is Fauja? 101.
61
00:04:34,080 –> 00:04:37,000
Born on 1st April 1911.
62
00:04:37,000 –> 00:04:41,000
Unfortunately he hasn’t quite
mastered the English language yet.
63
00:04:41,000 –> 00:04:44,200
Do you mind asking him how he’s feeling?
64
00:04:44,200 –> 00:04:46,360
THEY SPEAK IN PUNJABI
65
00:04:49,440 –> 00:04:51,680
He goes, “It’s not easy…” Yeah?
66
00:04:51,680 –> 00:04:56,960
But the job’s got to be done, cos he’s not
finished yet. You’re not going to give up, are you?
67
00:05:02,840 –> 00:05:05,200
Although he’s 101,
68
00:05:05,200 –> 00:05:09,160
Fauja has never had surgery,
69
00:05:09,160 –> 00:05:13,440
he shows no signs of heart disease…
70
00:05:13,440 –> 00:05:16,320
and he takes no medication.
71
00:05:20,160 –> 00:05:23,040
He believes that his long life
72
00:05:23,040 –> 00:05:26,240
and his incredible health
is down to his diet.
73
00:05:28,480 –> 00:05:30,680
So, any particular diet?
74
00:05:30,680 –> 00:05:33,200
He has no particular diet.
75
00:05:33,200 –> 00:05:39,200
It’s a simple Punjabi farmer’s
diet, so just fresh food,
76
00:05:39,200 –> 00:05:42,080
but his secret is that he
has smaller portions. Right.
77
00:05:42,080 –> 00:05:45,040
In poor countries,
people die of starvation.
78
00:05:45,040 –> 00:05:48,600
In rich countries,
people die of over-eating.
79
00:05:48,600 –> 00:05:52,080
So, how much does he
eat, compared to you or I?
80
00:05:52,080 –> 00:05:55,120
He would eat what would be
considered half a portion,
81
00:05:55,120 –> 00:05:57,640
almost a child’s portion.
82
00:05:57,640 –> 00:06:02,000
So a child portion is probably about half
the amount of calories you or I would eat?
83
00:06:04,840 –> 00:06:08,720
By restricting his food
intake so dramatically,
84
00:06:08,720 –> 00:06:12,960
Fauja has unknowingly been testing
a theory that has been around
85
00:06:12,960 –> 00:06:15,280
nearly as long as he has.
86
00:06:17,480 –> 00:06:21,680
A scientific theory which is only
now really coming into its own.
87
00:06:26,920 –> 00:06:30,720
I’ve taken the Tube to the finish line.
88
00:06:30,720 –> 00:06:33,760
I want to catch Fauja become, hopefully,
89
00:06:33,760 –> 00:06:36,960
the world’s oldest marathon runner.
90
00:06:44,880 –> 00:06:49,800
And after seven hours and
49 minutes, he succeeds.
91
00:06:49,800 –> 00:06:52,920
CHEERING AND APPLAUSE
92
00:06:55,760 –> 00:06:58,280
Can I congratulate you?
93
00:07:12,440 –> 00:07:15,960
That is absolutely unbelievable
– he’s 101 years old
94
00:07:15,960 –> 00:07:19,080
and he has just covered 26 miles.
95
00:07:19,080 –> 00:07:22,480
Now, I can’t imagine
that, in 50 years’ time,
96
00:07:22,480 –> 00:07:24,800
I’m going to be running down The Mall,
97
00:07:24,800 –> 00:07:27,200
but I want to be like him.
98
00:07:27,200 –> 00:07:32,080
I want to be mentally active and physically
active, I want to stay younger for longer.
99
00:07:42,680 –> 00:07:45,960
For decades, teams of
scientists around the world
100
00:07:45,960 –> 00:07:49,000
have been intensely studying ageing.
101
00:07:49,000 –> 00:07:55,560
Now, clearly, genes play a significant
part in how quickly and well we age,
102
00:07:55,560 –> 00:07:58,760
but there’s nothing much
you can do about your genes.
103
00:07:58,760 –> 00:08:03,000
There is, however, something
you can do about what you eat.
104
00:08:06,880 –> 00:08:11,960
And here in America, they are starting
to turn out some truly remarkable research
105
00:08:11,960 –> 00:08:14,600
linking food with longevity.
106
00:08:14,600 –> 00:08:20,200
It seems it’s not just about WHAT
we eat, but how and when we eat it.
107
00:08:22,040 –> 00:08:27,480
Our story begins in the dust
bowls of America during the 1930s.
108
00:08:27,480 –> 00:08:30,600
There was a terrible
drought, food was scarce,
109
00:08:30,600 –> 00:08:34,760
and the whole country was in the
grips of the Great Depression.
110
00:08:34,760 –> 00:08:37,480
Now, you would imagine,
in such difficult times,
111
00:08:37,480 –> 00:08:42,040
that life expectancy would
fall, but in fact it rose.
112
00:08:44,440 –> 00:08:49,600
During the darkest years of
Great Depression – 1929 to 1933 –
113
00:08:49,600 –> 00:08:53,960
life expectancy increased
by a remarkable six years.
114
00:08:59,320 –> 00:09:03,080
Now, on the face of it,
that is really surprising,
115
00:09:03,080 –> 00:09:08,760
and yet, clues as to why could also be
found from research done back in the 1930s.
116
00:09:09,920 –> 00:09:13,320
Nutritionists at Cornell
University working with animals
117
00:09:13,320 –> 00:09:15,720
discovered that if you severely restrict
118
00:09:15,720 –> 00:09:20,080
the amount they eat, they live longer.
119
00:09:20,080 –> 00:09:22,840
Much, much longer.
120
00:09:25,880 –> 00:09:30,640
So the next obvious question
– if you do the same with humans,
121
00:09:30,640 –> 00:09:33,680
will it have the same effects?
122
00:09:35,640 –> 00:09:39,920
Well, it’s been eight decades
since that observation,
123
00:09:39,920 –> 00:09:43,320
and only now are scientists
really beginning to understand
124
00:09:43,320 –> 00:09:47,360
the link between calorie
restriction and longevity in humans.
125
00:09:47,360 –> 00:09:51,880
At long last, it seems, we
are starting to get answers.
126
00:10:00,920 –> 00:10:06,000
Washington University is at
the heart of this new science.
127
00:10:06,000 –> 00:10:09,080
We are rewriting human physiology here!
128
00:10:09,080 –> 00:10:11,040
It’s astonishing, you know,
129
00:10:11,040 –> 00:10:14,920
how simple dietary
intervention can really change
130
00:10:14,920 –> 00:10:17,840
how the human body works, basically.
131
00:10:19,720 –> 00:10:24,120
‘Professor Luigi Fontana has spent the
last ten years studying a group of people
132
00:10:24,120 –> 00:10:28,520
‘who severely calorie
restrict every single day.
133
00:10:30,280 –> 00:10:33,400
‘And he is astonished
by what he’s found.’
134
00:10:34,920 –> 00:10:37,800
These people, they look
like a different species.
135
00:10:37,800 –> 00:10:40,240
That’s quite a big
statement, isn’t it? Yes!
136
00:10:40,240 –> 00:10:45,040
We are finding that they are going to
live longer than their parents and brothers
137
00:10:45,040 –> 00:10:48,080
on the typical American
diet, or Western diets.
138
00:10:53,440 –> 00:10:56,040
‘Luigi is clearly impressed,
139
00:10:56,040 –> 00:11:00,920
‘so I wanted to meet one of this
new species of human for myself.’
140
00:11:00,920 –> 00:11:04,800
A lovely, lovely house. Were the
directions good? Very good, thank you.
141
00:11:04,800 –> 00:11:07,280
Joe Cordell is a CRonie –
142
00:11:07,280 –> 00:11:10,640
a calorie restrictor
on optimal nutrition.
143
00:11:10,640 –> 00:11:14,240
And that means a lot of fruit and veg.
144
00:11:16,280 –> 00:11:18,800
I went ahead and kind
of put everything out
145
00:11:18,800 –> 00:11:22,920
because I thought you might want to have some
breakfast. That would be delicious, thank you.
146
00:11:22,920 –> 00:11:25,120
When I imagine a calorie restrictor,
147
00:11:25,120 –> 00:11:30,120
I imagine someone who lives basically on a
couple of carrots, or something like that.
148
00:11:30,120 –> 00:11:34,160
I didn’t think you’d
go in for breakfast.
149
00:11:34,160 –> 00:11:37,720
‘Joe kicks off his day
with a mountain of fruit,
150
00:11:37,720 –> 00:11:40,360
‘some of which he then throws away.’
151
00:11:41,360 –> 00:11:45,840
Then what I like to do is add some apple
to it, but when you’re in my position,
152
00:11:45,840 –> 00:11:50,840
I want to get as much nutritional
value as I can for the calorie,
153
00:11:50,840 –> 00:11:53,480
and virtually all the
nutritional value is in the peel.
154
00:11:53,480 –> 00:11:56,960
So you’re going to slip the peel
in and throw away the rest of it?
155
00:11:56,960 –> 00:11:59,960
You’re going to do the
reverse of what most people do.
156
00:11:59,960 –> 00:12:04,160
It’s great, because literally 95%
of the nutritional value here…
157
00:12:04,160 –> 00:12:07,840
Is in the skin? Yeah. The
rest is sugar and calories.
158
00:12:07,840 –> 00:12:11,480
This is generally what I’ll have
each morning The whole thing?
159
00:12:11,480 –> 00:12:13,080
Yeah. That’s a big bowl.
160
00:12:13,080 –> 00:12:17,360
Do you ever think, “What if I’m
wrong? What if it’s all wrong?
161
00:12:17,360 –> 00:12:22,360
“I’ve done this for 10, 20 years, and
then a new bit of science comes out
162
00:12:22,360 –> 00:12:25,200
“which says it’s actually all nonsense.”
163
00:12:25,200 –> 00:12:28,840
I tell you, my brother, who
weighs 100 lb more than I do,
164
00:12:28,840 –> 00:12:33,720
he’s about my age. He’s all
the time making the joke to me
165
00:12:33,720 –> 00:12:36,640
that he’s going to end up out-living me
166
00:12:36,640 –> 00:12:39,280
and, in his opinion, I will
have suffered for nothing.
167
00:12:39,280 –> 00:12:41,360
But the point is, I enjoy doing it.
168
00:12:41,360 –> 00:12:44,000
Living a healthy lifestyle is fun.
169
00:12:44,000 –> 00:12:49,080
‘There are an estimated
100,000 CRonies worldwide –
170
00:12:49,080 –> 00:12:53,680
‘people living on a diet
which is rich in nutrients
171
00:12:53,680 –> 00:12:55,520
‘but low in calories.
172
00:12:55,520 –> 00:12:59,080
‘Joe looks fit, but
not impressively young.
173
00:12:59,080 –> 00:13:02,160
‘Perhaps Luigi has been exaggerating.’
174
00:13:02,160 –> 00:13:05,480
What I’d love to do is take
you off and do a number of tests
175
00:13:05,480 –> 00:13:07,120
and see just how we compare.
176
00:13:07,120 –> 00:13:11,120
OK, I’m game. So, is this a challenge?
177
00:13:11,120 –> 00:13:16,040
This is a challenge indeed, a
challenge I suspect I may well lose!
178
00:13:20,040 –> 00:13:25,360
For a decade, Joe’s been
eating 1,900 calories a day.
179
00:13:25,360 –> 00:13:28,720
I’ve averaged around 2,300,
180
00:13:28,720 –> 00:13:31,560
quite a few of them donuts and burgers.
181
00:13:31,560 –> 00:13:33,880
How much do you think you weigh?
182
00:13:33,880 –> 00:13:37,640
Probably about 180. Ooh, more than 180!
183
00:13:37,640 –> 00:13:39,280
Breathe in!
184
00:13:39,280 –> 00:13:44,000
I should be around 134, 135, 136.
185
00:13:44,000 –> 00:13:46,480
We just have to move it down one notch.
186
00:13:46,480 –> 00:13:49,120
134. Oh, right on.
187
00:13:51,240 –> 00:13:55,320
We’re both in our 50s,
and I really don’t think
188
00:13:55,320 –> 00:13:58,680
we look like different
generations, let alone species.
189
00:13:58,680 –> 00:14:01,520
So how different are we?
190
00:14:01,520 –> 00:14:05,280
I just need for you to
relax. Sit still, no talking.
191
00:14:08,640 –> 00:14:12,880
Some of the simplest ways of assessing
ageing don’t need specialist equipment.
192
00:14:12,880 –> 00:14:14,240
Oh, this is good.
193
00:14:14,240 –> 00:14:17,040
Balance is controlled by your inner ear.
194
00:14:21,560 –> 00:14:24,600
‘As you age, ear structures deteriorate
195
00:14:24,600 –> 00:14:27,120
‘and your balance gets worse.
196
00:14:27,120 –> 00:14:30,920
One more. ‘You can test it
by standing on your weaker leg
197
00:14:30,920 –> 00:14:32,720
‘with your eyes closed.’
198
00:14:32,720 –> 00:14:36,360
How long did I make? 6.59
seconds. Not very good.
199
00:14:36,360 –> 00:14:38,360
‘Not good at all.
200
00:14:38,360 –> 00:14:41,920
‘The average 55-year-old
should manage 8 seconds.’
201
00:14:41,920 –> 00:14:43,760
You’re down to…
202
00:14:43,760 –> 00:14:47,720
Yeah, you’re doing well
for the average 20-year-old.
203
00:14:47,720 –> 00:14:50,400
Over 30 seconds is what
most 20-year-olds can manage,
204
00:14:50,400 –> 00:14:52,960
but it’s one of those skills
that drops off dramatically.
205
00:14:52,960 –> 00:14:56,680
I think you’ve proved a
point. Stop. You can stop, yes.
206
00:14:58,720 –> 00:15:03,040
‘Another good test is reaction
time, which drops off with age.’
207
00:15:03,040 –> 00:15:04,840
Not good. Eight.
208
00:15:04,840 –> 00:15:07,600
‘This one only needs a ruler.
209
00:15:07,600 –> 00:15:11,320
‘At our age, you should be able to
catch it around the five-inch mark.’
210
00:15:13,200 –> 00:15:16,680
Very good. That was 4. You’re
doing pretty well, I must admit.
211
00:15:21,480 –> 00:15:25,120
Luigi’s methods are
rather more scientific.
212
00:15:25,120 –> 00:15:28,600
We did a range of other medical tests,
213
00:15:28,600 –> 00:15:30,920
including blood tests.
214
00:15:30,920 –> 00:15:34,680
Now he’s about to give us our results.
215
00:15:34,680 –> 00:15:37,800
Feels like being in the
headmaster’s office, doesn’t it?
216
00:15:37,800 –> 00:15:39,200
Waiting for the results.
217
00:15:39,200 –> 00:15:43,160
Will you get an A-star?
Will I get a B-minus?
218
00:15:43,160 –> 00:15:45,080
‘Luigi’s face tells me
219
00:15:45,080 –> 00:15:48,480
‘that what I’m about to
hear is not good news.’
220
00:15:48,480 –> 00:15:53,600
Total body fat in Joseph is 11.5%.
221
00:15:53,600 –> 00:15:57,640
This is typical of a super athlete.
222
00:15:57,640 –> 00:16:01,000
11% body fat is very low
223
00:16:01,000 –> 00:16:04,720
for a 54-,
55-year-old man.
224
00:16:04,720 –> 00:16:07,360
Yours is 27.1% fat.
225
00:16:07,360 –> 00:16:09,240
A third of your body is fat.
226
00:16:09,240 –> 00:16:13,280
Thank you…for making
that point so emphatically!
227
00:16:13,280 –> 00:16:17,640
‘And he’s still not done
talking about my fat.’
228
00:16:17,640 –> 00:16:19,720
Abdominal fat is around 30%.
229
00:16:19,720 –> 00:16:23,760
Abdominal fat is really the bad guy.
230
00:16:23,760 –> 00:16:26,480
The higher the abdominal
fat, the higher the risk
231
00:16:26,480 –> 00:16:29,560
of developing type 2 diabetes,
cardiovascular disease.
232
00:16:29,560 –> 00:16:32,680
No doubt about it. It’s also
a risk factor for cancer.
233
00:16:33,880 –> 00:16:37,920
So, basically, your
cardiometabolic profile,
234
00:16:37,920 –> 00:16:39,920
it’s not good. For your age.
235
00:16:39,920 –> 00:16:42,400
I think you should do
something to improve it.
236
00:16:42,400 –> 00:16:44,800
What we can say is that Joseph
237
00:16:44,800 –> 00:16:48,280
is not going to develop
cardiovascular disease.
238
00:16:48,280 –> 00:16:50,480
It’s impossible to develop stroke,
239
00:16:50,480 –> 00:16:53,080
myocardial infarction or heart failure.
240
00:16:53,080 –> 00:16:56,080
These three diseases are responsible
241
00:16:56,080 –> 00:16:58,960
for 40% of the deaths now in US and UK.
242
00:16:58,960 –> 00:17:02,280
No chance he’ll die of that?
I mean, one in a million.
243
00:17:02,280 –> 00:17:06,040
And if I were to go
onto Joe’s lifestyle…?
244
00:17:06,040 –> 00:17:08,560
In a year, you are going to be cured.
245
00:17:12,360 –> 00:17:16,040
I now understand what Luigi means.
246
00:17:16,040 –> 00:17:20,600
It is as if we are
two different species.
247
00:17:20,600 –> 00:17:24,600
Joe’s diet seems to be keeping
his organs in pristine condition.
248
00:17:24,600 –> 00:17:28,080
My diet is undermining
my health, and fast.
249
00:17:30,480 –> 00:17:34,840
Well, that was very sobering.
Luigi does not mince his words.
250
00:17:34,840 –> 00:17:36,920
He talked a bit about abdominal fat.
251
00:17:36,920 –> 00:17:39,440
In fact, he talked quite a
lot about my abdominal fat.
252
00:17:39,440 –> 00:17:42,160
I’ve never thought of
myself as particularly fat.
253
00:17:42,160 –> 00:17:45,120
But it was the sort of two
visions he held out to me.
254
00:17:45,120 –> 00:17:48,240
One, where, if I continue
as I am at the moment,
255
00:17:48,240 –> 00:17:53,000
I’m heading almost certainly for
heart disease and possibly worse.
256
00:17:53,000 –> 00:17:57,720
The other is, if I embrace
the calorie restriction way,
257
00:17:57,720 –> 00:18:01,960
he said I could be effectively
cured in less than a year.
258
00:18:01,960 –> 00:18:06,160
My risk factors would move
from being almost certainly
259
00:18:06,160 –> 00:18:08,520
a cardiac victim at some point
260
00:18:08,520 –> 00:18:10,360
to one in a million.
261
00:18:10,360 –> 00:18:15,400
When you put it as starkly as that,
it’s given me a lot to think about.
262
00:18:31,160 –> 00:18:35,920
Even though the evidence supporting
the benefits of calorie restriction
263
00:18:35,920 –> 00:18:38,800
is getting stronger all the time,
264
00:18:38,800 –> 00:18:42,640
I cannot in all honesty imagine
myself doing what Joe does.
265
00:18:45,080 –> 00:18:48,080
Which creates something of a dilemma.
266
00:18:50,080 –> 00:18:53,480
So, what I really want to do is try
267
00:18:53,480 –> 00:18:57,880
to understand the ways in
which calorie restriction works,
268
00:18:57,880 –> 00:19:01,240
then hopefully I can get
all the delicious benefits
269
00:19:01,240 –> 00:19:03,960
without actually having to do it.
270
00:19:03,960 –> 00:19:05,560
I’m in Los Angeles,
271
00:19:05,560 –> 00:19:09,400
a city that is notoriously
addicted to youth.
272
00:19:09,400 –> 00:19:12,280
In fact, many people here seem to think
273
00:19:12,280 –> 00:19:15,520
that growing old and
wrinkled is optional.
274
00:19:15,520 –> 00:19:19,360
I’m not going to see anyone as
superficial as a plastic surgeon.
275
00:19:19,360 –> 00:19:23,280
I’m here to meet one of the
world’s foremost experts on ageing.
276
00:19:31,640 –> 00:19:34,280
Hi, there. Hey.
277
00:19:34,280 –> 00:19:39,400
Professor Valter Longo studies the
complex mechanisms which control ageing.
278
00:19:41,600 –> 00:19:47,120
He’s honed in on a critical pathway
that links what we eat with how we age.
279
00:19:49,400 –> 00:19:52,360
He’s taking me to see two mice.
280
00:19:52,360 –> 00:19:58,160
They are both the same
age, same species, same sex.
281
00:19:58,160 –> 00:20:02,040
But there’s one significant
difference between them.
282
00:20:02,040 –> 00:20:06,040
The little one is going to
be living an awful lot longer
283
00:20:06,040 –> 00:20:08,120
than the big one.
284
00:20:11,320 –> 00:20:13,560
This little mouse right here
285
00:20:13,560 –> 00:20:17,720
holds the world record for
longevity extension in a mammal.
286
00:20:17,720 –> 00:20:19,920
Oh, right. That is remarkable.
287
00:20:19,920 –> 00:20:22,840
So, how long would these
subspecies of mice last?
288
00:20:22,840 –> 00:20:25,560
The big mouse here, about two years,
289
00:20:25,560 –> 00:20:28,480
and the little mouse,
about a 40% longer lifespan.
290
00:20:28,480 –> 00:20:30,880
Right. They’re very
different, aren’t they?
291
00:20:30,880 –> 00:20:33,120
Whoa! He is trying to bite me.
292
00:20:33,120 –> 00:20:35,600
HE LAUGHS
293
00:20:35,600 –> 00:20:40,120
I could feel that one going through.
Should’ve had the double glove.
294
00:20:40,120 –> 00:20:43,360
I learned the hard way!
295
00:20:43,360 –> 00:20:46,400
The big mouse already has
a 50% chance of being dead.
296
00:20:46,400 –> 00:20:48,560
OK, so he’s doing well to be alive?
297
00:20:48,560 –> 00:20:51,000
He’s lucky to be alive, that’s right.
298
00:20:51,000 –> 00:20:54,680
The small one probably has
another year to go. Oh, right.
299
00:20:54,680 –> 00:20:57,640
The little guy will live on to the
equivalent of what, 120 in human?
300
00:20:57,640 –> 00:21:02,680
Exactly, yeah. Another 30
to 40 years in human years.
301
00:21:02,680 –> 00:21:06,920
Can I pick it up? Go
ahead. By the tail. OK.
302
00:21:10,040 –> 00:21:11,680
The little mouse I’m holding
303
00:21:11,680 –> 00:21:15,160
is actually a man-made creation.
304
00:21:15,160 –> 00:21:18,520
The reason he’s so
small and so long lived
305
00:21:18,520 –> 00:21:21,720
is because he’s been
genetically engineered.
306
00:21:21,720 –> 00:21:26,000
He has incredibly low
levels of a growth hormone
307
00:21:26,000 –> 00:21:29,080
called Insulin-like Growth Factor 1.
308
00:21:29,080 –> 00:21:32,240
And it seems IGF-1 is a key factor
309
00:21:32,240 –> 00:21:35,760
linking calorie
restriction and longevity.
310
00:21:42,080 –> 00:21:46,240
Clues to the link come
from this group of people
311
00:21:46,240 –> 00:21:48,880
who live in a remote region of Ecuador.
312
00:21:50,720 –> 00:21:54,760
They have a very rare
condition called Laron syndrome,
313
00:21:54,760 –> 00:21:58,960
which affects less than
350 people worldwide.
314
00:22:03,360 –> 00:22:05,960
That’s you, is it? It makes you
look like a giant, doesn’t it?
315
00:22:05,960 –> 00:22:08,600
I’m the tall guy there.
316
00:22:08,600 –> 00:22:13,120
The shortest one is just over
three-and-a-half feet tall.
317
00:22:13,120 –> 00:22:15,160
Up to my belly button.
Is that right? Yeah.
318
00:22:15,160 –> 00:22:20,840
‘What interests researchers
like Valter is not their size,
319
00:22:20,840 –> 00:22:25,960
‘but the fact that they seem to be virtually
immune to two of the West’s biggest killers.’
320
00:22:25,960 –> 00:22:27,680
The big findings, of course,
321
00:22:27,680 –> 00:22:31,160
were, they don’t seem to get
either diabetes or cancer.
322
00:22:31,160 –> 00:22:33,720
Do they do all the normal,
sensible things we all do,
323
00:22:33,720 –> 00:22:37,160
like drink, smoke and all that?
Yes, they do the normal, and more,
324
00:22:37,160 –> 00:22:39,760
so they a very unhealthy lifestyle.
325
00:22:39,760 –> 00:22:43,720
Most of them are to some
extent at least overweight.
326
00:22:43,720 –> 00:22:46,520
They seem to really not
watch anything they do.
327
00:22:46,520 –> 00:22:49,640
They smoke or eat very
high calorie diets,
328
00:22:49,640 –> 00:22:53,440
and then they look at me and they say,
329
00:22:53,440 –> 00:22:55,080
“Oh, it doesn’t matter. I’m immune.”
330
00:22:55,080 –> 00:22:59,480
But the incredible thing
is that there’s no evidence
331
00:22:59,480 –> 00:23:02,920
of a single one of them
ever dying of cancer,
332
00:23:02,920 –> 00:23:06,640
yet their normal-height relatives
get cancer like everybody else.
333
00:23:08,000 –> 00:23:13,000
People with Laron syndrome have
a mutation which makes them small,
334
00:23:13,000 –> 00:23:17,280
but which also seems to protect
them against all these diseases.
335
00:23:19,320 –> 00:23:21,440
It’s incredible working with them.
336
00:23:23,640 –> 00:23:29,120
It’s a great group, and of course for
us is a group that in one mutation,
337
00:23:29,120 –> 00:23:33,480
can tell us about diabetes, cancer,
cardiovascular diseases and ageing.
338
00:23:37,240 –> 00:23:40,440
The Ecuadorian villagers
and the long-lived mice
339
00:23:40,440 –> 00:23:42,720
have something in common.
340
00:23:42,720 –> 00:23:46,240
Their bodies produce
exceptionally low levels
341
00:23:46,240 –> 00:23:48,080
of the growth hormone IGF-1.
342
00:23:50,520 –> 00:23:56,440
This discovery helped Valter piece
together role that IGF-1 plays
343
00:23:56,440 –> 00:23:59,400
in the complicated business of ageing.
344
00:23:59,400 –> 00:24:02,800
Our bodies are
normally in go-go mode –
345
00:24:02,800 –> 00:24:07,560
cells constantly driven
to divide by IGF-1.
346
00:24:07,560 –> 00:24:10,400
But when IGF-1 levels drop,
347
00:24:10,400 –> 00:24:14,080
our cells shift into a
completely different mode.
348
00:24:14,080 –> 00:24:17,480
The body slows production of new cells
349
00:24:17,480 –> 00:24:20,800
and starts repairing
existing ones instead.
350
00:24:20,800 –> 00:24:25,520
DNA damage is more likely to get fixed.
351
00:24:25,520 –> 00:24:29,480
And that’s why the mice AND
the villagers are protected
352
00:24:29,480 –> 00:24:31,600
from age-related diseases.
353
00:24:40,480 –> 00:24:44,160
But what’s the link to
calorie restriction in humans?
354
00:24:44,160 –> 00:24:49,960
Valter has lined up a very
simple, very Californian analogy.
355
00:24:51,440 –> 00:24:55,040
It turns out there is
something in the food we eat
356
00:24:55,040 –> 00:24:59,280
that affects how much
IGF-1 our bodies produce.
357
00:24:59,280 –> 00:25:01,880
That something is protein.
358
00:25:02,920 –> 00:25:07,800
When we eat a lot of protein, our
cells get locked in go-go mode.
359
00:25:07,800 –> 00:25:10,920
So it’s basically like slamming
your foot on the accelerator,
360
00:25:10,920 –> 00:25:13,320
saying, “Go! Go! Go!”
Is that right? Exactly.
361
00:25:13,320 –> 00:25:17,000
It’s pushing the cell to burn fuel.
362
00:25:17,000 –> 00:25:19,000
In go-go mode,
363
00:25:19,000 –> 00:25:22,800
the body is more susceptible
to some cancers and diabetes,
364
00:25:22,800 –> 00:25:25,120
because your cells are growing too fast
365
00:25:25,120 –> 00:25:27,440
for damage to be efficiently repaired.
366
00:25:27,440 –> 00:25:30,760
So it’s like driving
your car all the time
367
00:25:30,760 –> 00:25:32,560
and never taking it to the mechanic.
368
00:25:32,560 –> 00:25:36,160
Right, so that’s the key,
basically, is to somehow find a way
369
00:25:36,160 –> 00:25:39,120
to switch your body from
going, “Broom, broom, broom,”
370
00:25:39,120 –> 00:25:44,080
into a sort of repair mode, “Look
after me, make my DNA better.” Exactly.
371
00:25:46,480 –> 00:25:49,400
So, how do you reduce your IGF-1?
372
00:25:50,520 –> 00:25:54,560
Well, studies on calorie restrictors
suggests that eating less helps,
373
00:25:54,560 –> 00:25:55,960
but it’s not enough.
374
00:25:57,040 –> 00:26:01,280
As well as cutting calories, you
have to cut your protein intake.
375
00:26:01,280 –> 00:26:05,640
Not entirely
– that would be a very bad idea.
376
00:26:05,640 –> 00:26:08,520
It’s about sticking to
recommended guidelines,
377
00:26:08,520 –> 00:26:11,800
something most of us fail to do.
378
00:26:11,800 –> 00:26:15,840
And you don’t have to be
a CRonie to lower IGF-1.
379
00:26:15,840 –> 00:26:18,840
There is another way
– fasting.
380
00:26:18,840 –> 00:26:25,560
In fasting, there is a much more
dramatic and much quicker response,
381
00:26:25,560 –> 00:26:30,880
and so, within 24 hours, you
decrease your glucose level
382
00:26:30,880 –> 00:26:35,480
and you decrease your main
growth factor, which is IGF-1.
383
00:26:38,360 –> 00:26:42,960
I do find it hard to believe
that just a few days of fasting
384
00:26:42,960 –> 00:26:47,480
is going to be enough to jolt my
body into a more healthy state.
385
00:26:49,200 –> 00:26:53,720
But I’m certainly intrigued,
and I want to find out more.
386
00:26:53,720 –> 00:26:56,360
So I’ve had my IGF
measured back in London,
387
00:26:56,360 –> 00:26:59,200
and they tell me that it’s 28.
388
00:26:59,200 –> 00:27:01,200
Is that good? Bad?
389
00:27:01,200 –> 00:27:05,160
That’s not very bad,
but that’s high enough
390
00:27:05,160 –> 00:27:09,160
that, based on a number of
studies, including our own,
391
00:27:09,160 –> 00:27:14,480
it puts you in a higher risk category
for several different cancers,
392
00:27:14,480 –> 00:27:16,840
including prostate cancer.
393
00:27:16,840 –> 00:27:21,320
Valter believes I should start to
see some pretty impressive results
394
00:27:21,320 –> 00:27:25,400
after just three days and
four nights of fasting.
395
00:27:25,400 –> 00:27:27,680
But it’s a daunting prospect.
396
00:27:29,040 –> 00:27:32,080
I think fasting’s quite tough,
isn’t it? Have you done it yourself?
397
00:27:32,080 –> 00:27:34,280
I’ve done it myself, yes,
398
00:27:34,280 –> 00:27:38,280
I’ve fasted for four days several times
399
00:27:38,280 –> 00:27:39,920
and to me it was very tough, yeah.
400
00:27:39,920 –> 00:27:43,360
And still, if I look
ahead at doing fasting,
401
00:27:43,360 –> 00:27:46,800
I see it as a tough four
days, I’m not looking forward.
402
00:27:46,800 –> 00:27:48,920
Some people do, but I don’t.
403
00:27:48,920 –> 00:27:52,600
I’m Italian, so I look forward
to eating well, you know.
404
00:27:52,600 –> 00:27:55,200
I’ll bear that image in mind. Yeah.
405
00:27:55,200 –> 00:27:58,240
The greedy Italian stopping eating
when I’m feeling weak about it.
406
00:27:58,240 –> 00:27:59,440
There you go. Thank you.
407
00:28:08,520 –> 00:28:11,480
Prolonged fasting can be dangerous
408
00:28:11,480 –> 00:28:15,080
and Valter thinks it should only be
undertaken by people in good health
409
00:28:15,080 –> 00:28:18,240
and preferably, under close supervision.
410
00:28:18,240 –> 00:28:20,120
So he will be keeping an eye on me.
411
00:28:21,760 –> 00:28:26,360
OK, I’ve decided I’m
going to try this fast,
412
00:28:26,360 –> 00:28:29,280
which is going to be a
three-and-a-half-day fast
413
00:28:29,280 –> 00:28:35,120
and all I’m going to have
is lots of water, black tea
414
00:28:35,120 –> 00:28:39,520
and one 50-calorie
Cup-a-Soup a day.
415
00:28:39,520 –> 00:28:44,680
Now… Oh, God, I have never done
anything quite like this before,
416
00:28:44,680 –> 00:28:46,920
so I imagine it’s going
to be really tough.
417
00:28:46,920 –> 00:28:49,000
But I’m interested.
418
00:28:49,000 –> 00:28:52,640
I’m also, I must admit,
quite concerned about some of
419
00:28:52,640 –> 00:28:55,880
the rather bad news, health
news I’ve been getting recently,
420
00:28:55,880 –> 00:29:01,960
so, um…it’ll be a challenge,
but I’m sure I’ll manage it.
421
00:29:03,360 –> 00:29:05,720
Reasonably sure.
422
00:29:08,520 –> 00:29:10,920
And so, my fast begins.
423
00:29:17,480 –> 00:29:22,600
Right. It is now 10.30
at night and I am hungry.
424
00:29:22,600 –> 00:29:29,120
It has been, oh, just about 25
hours since I last ate a meal
425
00:29:29,120 –> 00:29:35,360
and the prospect of going to bed
while hungry is not a great one.
426
00:29:36,960 –> 00:29:39,680
I think it’s getting to me,
because last night I had a dream
427
00:29:39,680 –> 00:29:44,080
and I dreamt I ate a sandwich and
then I felt fantastically guilty.
428
00:29:44,080 –> 00:29:47,960
So vivid, I had a look round to see if there
were any crumbs in the bed, but there weren’t.
429
00:29:47,960 –> 00:29:50,440
I guess time to go to work.
430
00:29:53,480 –> 00:29:56,240
Simple dietary intervention
431
00:29:56,240 –> 00:29:59,120
can really change how
the human body works.
432
00:29:59,120 –> 00:30:01,600
It puts you in a higher risk category.
433
00:30:04,440 –> 00:30:08,920
Just as Valter warned me,
the first day was tough.
434
00:30:08,920 –> 00:30:11,520
Not really because I was that hungry,
435
00:30:11,520 –> 00:30:15,880
but simply because I had never
done anything like this before.
436
00:30:15,880 –> 00:30:18,880
It was fear of the unknown.
437
00:30:18,880 –> 00:30:22,720
My nightfall, I’m beginning to
think this is a very bad idea…
438
00:30:25,400 –> 00:30:28,280
..particularly when I
had dinner with the crew.
439
00:30:33,600 –> 00:30:36,120
Or rather, when they had dinner.
440
00:30:38,160 –> 00:30:41,720
So, yeah, here I am in a
nice old Korean restaurant
441
00:30:41,720 –> 00:30:45,200
with the rest of the crew.
442
00:30:45,200 –> 00:30:48,240
And they are currently digging in…
443
00:30:48,240 –> 00:30:50,440
Enjoying it, guys?
444
00:30:50,440 –> 00:30:51,680
Beautiful. Yes.
445
00:30:51,680 –> 00:30:56,560
It’s a good smell. I really,
really wouldn’t mind a little bite.
446
00:30:59,480 –> 00:31:02,080
I do feel very hungry.
447
00:31:03,760 –> 00:31:08,720
Fortunately, my dinner is
waiting for me in my hotel room.
448
00:31:13,080 –> 00:31:15,880
I had to leave, I couldn’t
bear it any longer.
449
00:31:22,360 –> 00:31:26,440
HE SIGHS My delicious miso soup here.
450
00:31:26,440 –> 00:31:29,280
Give a bit of a stir with the hotel pen,
451
00:31:29,280 –> 00:31:31,680
because there’s no other cutlery around.
452
00:31:33,240 –> 00:31:34,960
Mmm!
453
00:31:36,280 –> 00:31:38,960
Health. 25 calories’ worth.
454
00:31:38,960 –> 00:31:40,960
And I’m looking forward to it.
455
00:31:44,400 –> 00:31:46,440
Ah!
456
00:31:48,160 –> 00:31:52,160
OK, final full day of fasting.
457
00:31:52,160 –> 00:31:54,440
Delicious breakfast here, black tea.
458
00:31:54,440 –> 00:31:58,200
I’m feeling a bit light-headed
but otherwise actually all right.
459
00:31:58,200 –> 00:32:00,160
So, just 24 hours to go
460
00:32:00,160 –> 00:32:03,440
and now I’m pretty confident
I’ll be able to do it.
461
00:32:11,760 –> 00:32:15,120
I’ve learnt that hunger
does not build and build,
462
00:32:15,120 –> 00:32:16,880
but comes in waves that pass.
463
00:32:18,200 –> 00:32:21,760
By now, I have depleted
my body’s store of glucose
464
00:32:21,760 –> 00:32:26,200
and will have switched to
burning fat for fuel instead.
465
00:32:26,200 –> 00:32:27,960
And if Valter is right,
466
00:32:27,960 –> 00:32:33,000
my liver should also have
stopped producing so much IGF-1,
467
00:32:33,000 –> 00:32:36,040
putting my cells into repair mode.
468
00:32:39,680 –> 00:32:44,600
Finally, it’s 7am, day four,
I’m getting my blood test done.
469
00:32:45,600 –> 00:32:49,440
So, after this, I can go and
have breakfast? Absolutely.
470
00:32:49,440 –> 00:32:51,560
The first food for
three-and-a-half days,
471
00:32:51,560 –> 00:32:55,760
the first food for 86 hours.
Well, who’s counting(?)
472
00:32:55,760 –> 00:32:58,640
I’m just hoping that this
is going to show some change,
473
00:32:58,640 –> 00:33:02,120
particularly in my IGF, cos if I
have spent the last three-and-a-half
474
00:33:02,120 –> 00:33:05,440
to four days not eating and the
results have been absolutely zero,
475
00:33:05,440 –> 00:33:07,760
that would be very, very depressing.
476
00:33:09,800 –> 00:33:13,360
The fast is over.
477
00:33:13,360 –> 00:33:16,720
Mmm. Ah! That is very…
478
00:33:16,720 –> 00:33:19,400
I can just sort of begin
to feel the empty spaces.
479
00:33:19,400 –> 00:33:23,360
I wasn’t actually terrible hungry
when I woke up this morning, but…
480
00:33:25,840 –> 00:33:28,960
..when I start eating this, I
realise what it is I was missing.
481
00:33:33,280 –> 00:33:37,800
Later that afternoon, I meet
up with Valter to find out
482
00:33:37,800 –> 00:33:39,600
if it’s all been worthwhile.
483
00:33:41,120 –> 00:33:44,960
I broke my fast this morning, I
had some porridge and some bacon
484
00:33:44,960 –> 00:33:47,600
and I feel better. Oh, good, good.
485
00:33:47,600 –> 00:33:50,960
I’ll feel even more terrific
if these results are any good.
486
00:33:50,960 –> 00:33:53,640
Yeah, let’s take a look at them.
487
00:33:53,640 –> 00:33:58,240
So, your insulin-like growth factor
one, IGF-1, this is the normal value.
488
00:33:58,240 –> 00:34:01,640
Wow. The bad news, you’re almost
at the top of the normal range.
489
00:34:01,640 –> 00:34:03,760
For American standards,
you’re doing good.
490
00:34:03,760 –> 00:34:07,440
But not good full-stop, but not
bad. I’m an average American, am I?
491
00:34:07,440 –> 00:34:10,520
That’s right, yeah.
And the good news is,
492
00:34:10,520 –> 00:34:13,880
with your fasting diet, you
dropped to almost half. Wow.
493
00:34:13,880 –> 00:34:16,480
That’s big, isn’t it?
Yeah. That’s a big drop.
494
00:34:16,480 –> 00:34:18,960
It’s a very dramatic drop,
so you respond very well.
495
00:34:18,960 –> 00:34:20,960
I have to say, it was fascinating.
496
00:34:20,960 –> 00:34:25,400
Seeing that is very,
very… um, surprising.
497
00:34:25,400 –> 00:34:28,320
‘Surprising
– and a huge relief.
498
00:34:28,320 –> 00:34:32,360
‘Halving my IGF-1 should cut
my risk of certain cancers,
499
00:34:32,360 –> 00:34:34,920
‘like prostate cancer,
which my father had.
500
00:34:34,920 –> 00:34:37,880
‘My blood sugar has also
dropped to healthy levels,
501
00:34:37,880 –> 00:34:39,760
‘which I’m really pleased about.’
502
00:34:40,960 –> 00:34:47,840
I challenge you in four days to
get more extreme metabolic changes
503
00:34:47,840 –> 00:34:50,160
than these with anything you want.
504
00:34:50,160 –> 00:34:52,800
I think this is quite
extreme enough! Yeah.
505
00:34:52,800 –> 00:34:55,800
Yeah, but, you know, if you can
find something else that you can do,
506
00:34:55,800 –> 00:34:58,280
that it doesn’t hurt
you, that benefits you
507
00:34:58,280 –> 00:35:01,800
and that causes these
changes, I’d like to know. OK.
508
00:35:05,520 –> 00:35:08,280
But Valter says, unless I switch
509
00:35:08,280 –> 00:35:11,480
to a lower protein,
more plant-based diet,
510
00:35:11,480 –> 00:35:14,080
the effects won’t last.
511
00:35:16,040 –> 00:35:18,720
I’ll also need to fast
once every couple of months,
512
00:35:18,720 –> 00:35:21,920
to maintain the benefits.
513
00:35:21,920 –> 00:35:25,560
Can I really see myself doing that?
514
00:35:25,560 –> 00:35:27,720
You have to make a
decision now, in your case,
515
00:35:27,720 –> 00:35:29,240
what do you want to do, you know?
516
00:35:29,240 –> 00:35:32,240
And there is a lot of drugs
that you could be taking,
517
00:35:32,240 –> 00:35:34,000
and is that what you want to do?
518
00:35:34,000 –> 00:35:39,200
And if you do so, in a few
years, or in a number of years,
519
00:35:39,200 –> 00:35:43,080
you’re going to be the
typical 65-year-old in Europe
520
00:35:43,080 –> 00:35:47,120
that takes eight drugs a
day, and so that’s the option.
521
00:35:47,120 –> 00:35:50,200
MICHAEL LAUGHS And that’s your call.
522
00:35:50,200 –> 00:35:54,320
Thank you, OK! That’s
quite an interesting choice!
523
00:36:01,440 –> 00:36:04,360
That is really, really impressive,
524
00:36:04,360 –> 00:36:06,400
that in just
three-and-a-half days,
525
00:36:06,400 –> 00:36:09,160
if this data is right, and
the animal data is right,
526
00:36:09,160 –> 00:36:12,160
I have massively decreased my risk
527
00:36:12,160 –> 00:36:16,280
of a whole range of
age-related diseases.
528
00:36:16,280 –> 00:36:19,760
The big question in my
mind at the moment is,
529
00:36:19,760 –> 00:36:22,960
can I do fasting once a month,
530
00:36:22,960 –> 00:36:25,920
for however long it takes?
531
00:36:25,920 –> 00:36:28,200
Or is there a better
way, a different way,
532
00:36:28,200 –> 00:36:30,200
a more manageable way out there,
533
00:36:30,200 –> 00:36:33,640
that can do much of what this does,
534
00:36:33,640 –> 00:36:37,360
but perhaps with a little less pain?
535
00:36:37,360 –> 00:36:40,600
What I’ve discovered
about myself is that
536
00:36:40,600 –> 00:36:46,040
the biggest problem with
prolonged fasting is me.
537
00:36:48,480 –> 00:36:51,520
VALTER: ‘You have to
make a decision now.
538
00:36:51,520 –> 00:36:52,880
‘Fasting is tough.’
539
00:36:55,160 –> 00:36:58,360
Despite knowing all the
wonderful benefits…
540
00:37:00,480 –> 00:37:03,000
..I just can’t bring myself to do it.
541
00:37:15,680 –> 00:37:18,920
But the great thing about science
542
00:37:18,920 –> 00:37:22,720
is there is always
someone doing further work,
543
00:37:22,720 –> 00:37:25,280
building on what others have achieved,
544
00:37:25,280 –> 00:37:28,720
which is why I’m here in Chicago.
545
00:37:28,720 –> 00:37:33,320
Here, they are doing studies not
just on mice, but also on humans.
546
00:37:37,200 –> 00:37:39,920
And they seem to have found a way
547
00:37:39,920 –> 00:37:43,520
of making fasting a lot more palatable.
548
00:37:43,520 –> 00:37:48,440
I’m here to meet Dr Krista Varady,
549
00:37:48,440 –> 00:37:52,600
who has been researching
something that sounds easier.
550
00:37:52,600 –> 00:37:54,400
Alternate day fasting.
551
00:37:54,400 –> 00:37:57,040
Hello! Hello there! Hi!
552
00:37:57,040 –> 00:38:00,560
Very nice to meet you. Nice to
meet you! My name’s Krista Varady.
553
00:38:00,560 –> 00:38:02,360
Hello! So what have you got here, then?
554
00:38:02,360 –> 00:38:04,400
So this is some of the
components that we’d use
555
00:38:04,400 –> 00:38:08,040
in an alternate day fasting diet.
556
00:38:08,040 –> 00:38:11,560
It basically involves a day of
pretty heavy calorie restriction.
557
00:38:11,560 –> 00:38:13,720
For women, about 400
to 500 calories a day,
558
00:38:13,720 –> 00:38:16,280
and for men, about 500
to 600 calories a day,
559
00:38:16,280 –> 00:38:18,760
and that’s actually just as
one meal, around lunchtime.
560
00:38:18,760 –> 00:38:22,040
We call that the fast day.
561
00:38:22,040 –> 00:38:24,560
So the fast day isn’t
about total abstinence.
562
00:38:24,560 –> 00:38:27,640
It’s about meals that look like this.
563
00:38:27,640 –> 00:38:31,480
What’s great about alternate day fasting
564
00:38:31,480 –> 00:38:33,520
is what happens on the alternate days.
565
00:38:33,520 –> 00:38:36,920
And then that’s alternated with
something we call the feed day,
566
00:38:36,920 –> 00:38:40,560
which is where you can eat whatever
you want. Absolutely whatever you want.
567
00:38:40,560 –> 00:38:44,680
So here’s the pattern
of alternate day fasting.
568
00:38:44,680 –> 00:38:46,880
Fast day.
569
00:38:46,880 –> 00:38:47,960
Feed day.
570
00:38:47,960 –> 00:38:49,880
Fast day.
571
00:38:49,880 –> 00:38:51,320
Feed day.
572
00:38:51,320 –> 00:38:56,320
It certainly sounds easier
than either prolonged fasting
573
00:38:56,320 –> 00:38:59,120
or the daily calorie
restriction I looked at earlier.
574
00:38:59,120 –> 00:39:00,680
But is it as effective?
575
00:39:00,680 –> 00:39:04,800
Well, Krista’s currently doing
a trial with overweight subjects
576
00:39:04,800 –> 00:39:08,280
which suggests it might be.
577
00:39:08,280 –> 00:39:10,840
What we saw was that the
alternate day fasting group
578
00:39:10,840 –> 00:39:12,960
actually lost a bit more weight,
579
00:39:12,960 –> 00:39:16,360
so about 5lb more after
the 6-month period.
580
00:39:16,360 –> 00:39:21,480
And they actually saw some pretty
nice decreases in LDL cholesterol,
581
00:39:21,480 –> 00:39:23,240
as well as triglycerides.
582
00:39:23,240 –> 00:39:26,160
So LDL cholesterol is
the bad cholesterol,
583
00:39:26,160 –> 00:39:29,440
and triglycerides
– basically higher amounts of that
584
00:39:29,440 –> 00:39:32,720
can lead to heart disease
and age-related disease.
585
00:39:32,720 –> 00:39:36,280
We also see really nice
decreases in blood pressure
586
00:39:36,280 –> 00:39:37,840
over the course of the trials.
587
00:39:37,840 –> 00:39:42,040
So, again, another key
heart disease risk factor.
588
00:39:49,400 –> 00:39:51,800
‘In addition to so far
rather limited human trials,
589
00:39:51,800 –> 00:39:55,160
‘there’s lots of good
evidence from animal studies
590
00:39:55,160 –> 00:39:58,600
‘that alternate day fasting,
ADF, is safe and effective.
591
00:40:00,320 –> 00:40:02,880
‘I’m convinced enough to try it.
592
00:40:02,880 –> 00:40:05,400
‘Yesterday I fasted.
593
00:40:05,400 –> 00:40:07,360
‘Today I feed.’
594
00:40:07,360 –> 00:40:11,000
So hopefully, we will make
it back…easily enough.
595
00:40:11,000 –> 00:40:15,040
Ooh, magical mystery tour!
I like that! Yeah, yeah!
596
00:40:15,040 –> 00:40:18,160
MUSIC: ‘Johnny B Goode’ by Chuck Berry
597
00:40:27,120 –> 00:40:29,520
BUZZER Hi, thanks for stopping.
598
00:40:29,520 –> 00:40:31,360
May I take your order, please?
599
00:40:31,360 –> 00:40:35,520
♪ Deep down in Louisiana
Close to New Orleans
600
00:40:35,520 –> 00:40:37,520
♪ Way back up in the
woods among the evergreens
601
00:40:37,520 –> 00:40:40,360
♪ There stood a log cabin
made of earth and wood
602
00:40:40,360 –> 00:40:42,800
♪ Where lived a country
boy named Johnny B Goode. ♪
603
00:40:42,800 –> 00:40:44,160
A very good choice!
604
00:40:44,160 –> 00:40:47,040
I particularly like the green
stuff that’s oozing out of it.
605
00:40:47,040 –> 00:40:48,600
So, I must admit,
606
00:40:48,600 –> 00:40:52,440
I am surprised to be here.
607
00:40:52,440 –> 00:40:55,760
I kind of imagined you’d be
sticking on a sort of, um,
608
00:40:55,760 –> 00:40:58,080
you know, a veggie diet
or something like that.
609
00:40:58,080 –> 00:41:00,760
Or, yeah, a lot of salads
or something on the feed day?
610
00:41:00,760 –> 00:41:04,920
No, actually as long as you stick
to the calorie goals on the fast day,
611
00:41:04,920 –> 00:41:09,400
you can literally eat whatever
you like on the feed day.
612
00:41:09,400 –> 00:41:13,680
‘One of Krista’s most recent
studies compared two groups on ADF,
613
00:41:13,680 –> 00:41:16,560
‘one eating high fat, the other low fat,
614
00:41:16,560 –> 00:41:18,960
‘on their feed days.’
615
00:41:18,960 –> 00:41:21,120
I’m concerned about my blood glucose,
616
00:41:21,120 –> 00:41:23,000
I’m concerned about my cholesterol,
617
00:41:23,000 –> 00:41:25,440
I’m concerned about a
load of stuff. Yeah, yeah.
618
00:41:25,440 –> 00:41:29,240
Are those not, sort of, made
worse by eating high fat?
619
00:41:29,240 –> 00:41:31,320
That’s actually what
we thought would happen.
620
00:41:31,320 –> 00:41:32,640
And then, surprisingly,
621
00:41:32,640 –> 00:41:35,000
we saw the same decreases
in LDL cholesterol,
622
00:41:35,000 –> 00:41:36,880
so that’s the bad cholesterol,
623
00:41:36,880 –> 00:41:38,600
and in triglycerides,
624
00:41:38,600 –> 00:41:40,800
and also in blood pressure.
625
00:41:40,800 –> 00:41:43,000
So in terms of
cardiovascular disease risk,
626
00:41:43,000 –> 00:41:45,600
it didn’t matter if you were
eating a high-fat or low-fat diet.
627
00:41:45,600 –> 00:41:50,200
Another big surprise was
that, after a day of fasting,
628
00:41:50,200 –> 00:41:54,280
people rarely gorge
themselves on their feed days.
629
00:41:57,680 –> 00:42:01,320
So when we ask someone to consume 25%
of their energy needs on the fast day,
630
00:42:01,320 –> 00:42:03,880
I just thought that when I
started running these trials,
631
00:42:03,880 –> 00:42:05,920
that people would eat 175% the next day.
632
00:42:05,920 –> 00:42:09,120
But right from the
get-go, no matter what,
633
00:42:09,120 –> 00:42:13,840
people just can’t eat
that 175% the next day.
634
00:42:13,840 –> 00:42:16,320
Most people eat around the 110%.
635
00:42:16,320 –> 00:42:18,880
So just slightly over what
they usually eat, actually.
636
00:42:18,880 –> 00:42:21,320
You appear to be slowing
down the ageing process,
637
00:42:21,320 –> 00:42:23,000
or the diseases associated with it.
638
00:42:23,000 –> 00:42:25,600
You’re cutting the risks
of the diseases associated,
639
00:42:25,600 –> 00:42:28,120
which is quite a profound
thing to do. Yeah, absolutely.
640
00:42:33,640 –> 00:42:37,200
Krista’s research is
still in the early stages.
641
00:42:37,200 –> 00:42:40,360
But from what I’ve seen and experienced,
642
00:42:40,360 –> 00:42:42,520
I am now starting to be won over
643
00:42:42,520 –> 00:42:45,360
by the idea that a simple pattern
644
00:42:45,360 –> 00:42:49,040
of feast and fast can be powerful.
645
00:42:49,040 –> 00:42:54,000
It seems to have an impact which
goes beyond simply eating less.
646
00:42:54,000 –> 00:42:57,240
And I think it could
work for someone like me.
647
00:43:03,080 –> 00:43:05,920
My final stop is Baltimore.
648
00:43:05,920 –> 00:43:09,520
I’m here because I need
a final bit of motivation.
649
00:43:12,560 –> 00:43:17,240
There’s one aspect of ageing I
find more terrifying than any other.
650
00:43:17,240 –> 00:43:21,320
The effects of ageing on my brain.
651
00:43:24,280 –> 00:43:27,440
I’m trying to catch up
with Professor Mark Mattson.
652
00:43:27,440 –> 00:43:31,840
Mark is a leading expert
on the ageing brain.
653
00:43:31,840 –> 00:43:34,960
His research suggests that fasting
654
00:43:34,960 –> 00:43:37,800
may help delay the onset of diseases
655
00:43:37,800 –> 00:43:40,520
like Alzheimer’s,
dementia, and memory loss.
656
00:43:40,520 –> 00:43:41,680
Very good! How you doing?
657
00:43:41,680 –> 00:43:44,560
Hi there! Michael Mosley. Mark Mattson.
658
00:43:44,560 –> 00:43:47,520
You work here?! Work here? No!
659
00:43:47,520 –> 00:43:50,840
Nor do I work out
here! MICHAEL CHUCKLES.
660
00:43:50,840 –> 00:43:54,800
OK, Michael. We need
to put some booties on!
661
00:43:56,520 –> 00:43:59,880
We’re heading down into the basement
662
00:43:59,880 –> 00:44:03,080
of the National Institute on Ageing.
663
00:44:03,080 –> 00:44:04,280
OK? Yeah.
664
00:44:04,280 –> 00:44:06,000
Hidden away down here,
665
00:44:06,000 –> 00:44:09,720
there’s a special mouse
he’s keen to show me.
666
00:44:17,680 –> 00:44:20,400
This mouse is exploring a maze.
667
00:44:22,800 –> 00:44:25,680
It’s a memory test, designed
to see how well he remembers
668
00:44:25,680 –> 00:44:28,840
where he has found food before.
669
00:44:28,840 –> 00:44:32,000
So the food is actually in
there, is it? The food’s in here.
670
00:44:32,000 –> 00:44:35,920
The mice they study are destined
to develop Alzheimer’s disease.
671
00:44:38,440 –> 00:44:41,560
Normally, they succumb within
a relatively short time,
672
00:44:41,560 –> 00:44:44,360
but when these mice are put on a diet
673
00:44:44,360 –> 00:44:47,160
of feast days and fast days,
674
00:44:47,160 –> 00:44:50,120
what Mark calls “intermittent
energy restriction”,
675
00:44:50,120 –> 00:44:51,840
the results are incredible.
676
00:44:51,840 –> 00:44:55,680
..So that the animals on
intermittent energy restriction,
677
00:44:55,680 –> 00:44:58,240
they’ll live much longer with normal,
678
00:44:58,240 –> 00:44:59,880
at least, as best we can test,
679
00:44:59,880 –> 00:45:03,560
normal learning and memory,
before they start having problems.
680
00:45:03,560 –> 00:45:05,280
Significantly longer?
681
00:45:05,280 –> 00:45:07,480
Yeah, highly significantly.
682
00:45:07,480 –> 00:45:10,600
We found in one study,
six months to a year.
683
00:45:10,600 –> 00:45:14,280
That’s the equivalent in a
human of the difference between
684
00:45:14,280 –> 00:45:17,280
developing signs of Alzheimer’s
at say, the age of 50,
685
00:45:17,280 –> 00:45:20,760
and the age of 80? Something
like that? Is that right? Yeah.
686
00:45:20,760 –> 00:45:24,160
‘On the other hand, when the
mice eat a fast-food diet,
687
00:45:24,160 –> 00:45:27,640
‘they go downhill much earlier.’
688
00:45:27,640 –> 00:45:30,920
We give them… Lots of sugary
drinks? A high-fat diet, exactly.
689
00:45:30,920 –> 00:45:32,880
And we put fructose in
their drinking water,
690
00:45:32,880 –> 00:45:35,520
and that has a dramatic effect.
691
00:45:35,520 –> 00:45:37,920
The animals will have an earlier onset
692
00:45:37,920 –> 00:45:40,280
of the learning and memory problems.
693
00:45:40,280 –> 00:45:41,720
How much sooner?
694
00:45:41,720 –> 00:45:44,880
Um, three to four months sooner. Wow.
695
00:45:44,880 –> 00:45:48,760
So that is the equivalent of
them developing Alzheimer’s
696
00:45:48,760 –> 00:45:51,360
in their 30s or maybe early 40s? Right.
697
00:45:51,360 –> 00:45:55,120
So far, they’ve only
done studies in mice,
698
00:45:55,120 –> 00:45:58,040
but they’re about to
carry out human trials.
699
00:45:58,040 –> 00:46:00,400
How good if the evidence
that if someone like me
700
00:46:00,400 –> 00:46:02,520
were to start on intermittent fasting,
701
00:46:02,520 –> 00:46:05,520
it would cut my risk of
brain disease, broadly?
702
00:46:07,640 –> 00:46:10,000
I think, from the human standpoint,
703
00:46:10,000 –> 00:46:16,000
if we go on a scale from
poor to good to very good
704
00:46:16,000 –> 00:46:18,080
to excellent to outstanding,
705
00:46:18,080 –> 00:46:20,400
it’s in the very good
to excellent range.
706
00:46:21,760 –> 00:46:24,720
That’s the way I would categorise it.
707
00:46:29,560 –> 00:46:31,320
So, what’s going on?
708
00:46:33,440 –> 00:46:36,120
Well, when they examined the
brains of the fasting mice,
709
00:46:36,120 –> 00:46:39,440
they found something extraordinary.
710
00:46:39,440 –> 00:46:44,920
These green objects
are newborn brain cells.
711
00:46:44,920 –> 00:46:47,080
These three here are brand new?
712
00:46:47,080 –> 00:46:53,600
Sporadic bouts of hunger actually
trigger new neurons to grow.
713
00:46:53,600 –> 00:46:57,160
Why should a brain start to generate
714
00:46:57,160 –> 00:47:00,000
new nerve cells when
you stop feeding it?
715
00:47:00,000 –> 00:47:03,240
If you think about this in
evolutionary terms, it makes sense
716
00:47:03,240 –> 00:47:09,040
if you’re hungry, you’d better
increase your cognitive ability.
717
00:47:09,040 –> 00:47:11,280
That will give you a survival advantage,
718
00:47:11,280 –> 00:47:15,000
if you can remember where the
location of the food is and so on.
719
00:47:17,040 –> 00:47:22,760
It seems that fasting stresses your grey matter
the way that exercise stresses your muscles.
720
00:47:25,480 –> 00:47:30,160
So hunger really does make
you sharper? Yes. We think so.
721
00:47:34,080 –> 00:47:39,280
Mark’s research is starting to
point towards a simple conclusion.
722
00:47:39,280 –> 00:47:43,600
Alternate day fasting has
better effects on the brain
723
00:47:43,600 –> 00:47:47,480
than does a lower amount of
daily calorie restriction.
724
00:47:47,480 –> 00:47:53,280
It’s true of mice, but he needs to do
proper human trials to prove it’s true in us.
725
00:47:57,840 –> 00:48:02,000
I’ve come to the end of my search to
find out how to eat, fast and live longer.
726
00:48:03,200 –> 00:48:07,600
The official advice is, eat
at least 2,000 calories a day,
727
00:48:07,600 –> 00:48:11,640
and if you really want to fast,
even on an intermittent basis,
728
00:48:11,640 –> 00:48:15,920
see your doctor first, because
there are people it could harm,
729
00:48:15,920 –> 00:48:19,560
such as pregnant women or those
who are already underweight.
730
00:48:21,200 –> 00:48:25,960
I’m going to be cautious, and have decided
to go with a pattern that Mark recommended.
731
00:48:25,960 –> 00:48:31,680
Not alternate day fasting, but
a less extreme five/two diet –
732
00:48:31,680 –> 00:48:37,080
five days’ normal eating, followed
by two days’ fasting, each week.
733
00:48:38,360 –> 00:48:43,720
It’s my last day in the States, and
it has been absolutely eye opening.
734
00:48:43,720 –> 00:48:48,480
I had no idea at all that there
was so much research going on
735
00:48:48,480 –> 00:48:54,200
into fasting, calorie restriction in all
its forms, and sort of anti-ageing research.
736
00:48:55,200 –> 00:48:59,960
I’ve decided now that I am definitely
going to try the five/two diet,
737
00:48:59,960 –> 00:49:05,200
that’s five days’ normal eating,
then two days of 600 calories a day.
738
00:49:05,200 –> 00:49:07,760
I really, really hope
it makes a difference,
739
00:49:07,760 –> 00:49:11,360
because I’m conscious now that
I am really at the foothills
740
00:49:11,360 –> 00:49:14,720
of what could be quite
a steep advance into age,
741
00:49:14,720 –> 00:49:19,560
and if there is something that could
slow that ageing process down and give me
742
00:49:19,560 –> 00:49:25,360
more years of healthy living,
then I would really embrace that.
743
00:49:31,000 –> 00:49:35,280
I’m heading home to the UK.
744
00:49:35,280 –> 00:49:40,560
I’ve decided to give myself five
weeks to get used to my new diet,
745
00:49:40,560 –> 00:49:43,760
and see if I get results.
746
00:49:49,760 –> 00:49:52,520
This is going to be
one of my fasting days,
747
00:49:52,520 –> 00:49:55,240
and I’ve decided I’m going to
eat breakfast as my main meal.
748
00:49:55,240 –> 00:49:59,440
Mark Mattson told me he
doesn’t think it matters
749
00:49:59,440 –> 00:50:01,760
when you eat your
calories on a fast day.
750
00:50:01,760 –> 00:50:05,280
I’ve tried other things, but
it is really quite discouraging
751
00:50:05,280 –> 00:50:07,840
going into work when
you’re feeling hungry.
752
00:50:09,640 –> 00:50:12,480
There’s another reason I’m
determined to try this regime.
753
00:50:12,480 –> 00:50:16,040
When I arrived home, I
had another IGF-1 test.
754
00:50:17,040 –> 00:50:21,280
Annoyingly, my levels
were higher than ever.
755
00:50:21,280 –> 00:50:27,800
Turns out the hard-won effects of the
four-day fast only lasted a short while.
756
00:50:27,800 –> 00:50:30,680
And she’s kind of running
with it at the moment, I think.
757
00:50:30,680 –> 00:50:33,920
‘So I hope this is
something I can stick to.’
758
00:50:33,920 –> 00:50:37,280
Good. It’s done. It’s
actually twenty to two,
759
00:50:37,280 –> 00:50:41,040
and I don’t feel remotely
hungry, but it is lunchtime,
760
00:50:41,040 –> 00:50:44,920
so if nothing else, I think I’m
going to go and prowl around.
761
00:50:44,920 –> 00:50:50,680
MUSIC: “Harder, Better,
Faster, Stronger” by Daft Punk
762
00:51:02,400 –> 00:51:06,840
I found that fasting when
I’m busy at work was doable,
763
00:51:06,840 –> 00:51:09,720
but the next big test is my holiday.
764
00:51:09,720 –> 00:51:11,880
I’m walking with some friends.
765
00:51:11,880 –> 00:51:17,080
We are doing a walk across
the Trans-Pennine Way.
766
00:51:17,080 –> 00:51:22,080
Had breakfast this morning
about two hours ago,
767
00:51:22,080 –> 00:51:28,200
and I’m planning on eating
next breakfast tomorrow.
768
00:51:28,200 –> 00:51:32,160
So far I am feeling quite good.
769
00:51:35,080 –> 00:51:39,960
It’s now about seven o’clock.
Haven’t eaten for about 12 hours.
770
00:51:39,960 –> 00:51:43,520
The others are behind
me in the pub eating,
771
00:51:43,520 –> 00:51:47,640
so I decided to come
outside for a bit, because…
772
00:51:47,640 –> 00:51:50,400
I’m not as strong-minded
as I thought I was.
773
00:51:50,400 –> 00:51:53,480
My stomach is begin to rumble
a bit, but it’s all right.
774
00:51:57,880 –> 00:52:02,400
‘It’s been five weeks since
I started the five/two diet.’
775
00:52:02,400 –> 00:52:04,720
Heel! Heel!
776
00:52:04,720 –> 00:52:06,920
Not very good dog!
777
00:52:06,920 –> 00:52:10,520
‘I managed to fit in two 600
calorie fast days each week,
778
00:52:10,520 –> 00:52:13,960
‘though they tended to
be a bit scattered around.
779
00:52:13,960 –> 00:52:16,440
‘But has it been enough
to make a difference?’
780
00:52:17,840 –> 00:52:19,640
So, today’s results day.
781
00:52:19,640 –> 00:52:21,520
I have lost, I know, some weight,
782
00:52:21,520 –> 00:52:25,000
I’ll find out in a moment just
how much, but I’m mainly interested
783
00:52:25,000 –> 00:52:29,200
in the bloods, because five or six
weeks ago they were pretty terrible.
784
00:52:29,200 –> 00:52:34,280
I have high blood glucose,
high cholesterol, high IGF.
785
00:52:34,280 –> 00:52:37,480
And I’m really, really
keen to see them improve,
786
00:52:37,480 –> 00:52:41,400
because frankly, if they haven’t
improved, then I am in trouble,
787
00:52:41,400 –> 00:52:46,480
and I do want to stay young and
healthy for my family, for myself.
788
00:52:46,480 –> 00:52:51,800
So, I’m quite anxious, because
this matters an awful lot to me.
789
00:52:55,000 –> 00:52:59,080
Just to remind you, this is what I
looked like at the start of this film.
790
00:53:01,160 –> 00:53:04,040
And this is me today.
791
00:53:04,040 –> 00:53:06,640
I’ve had to add a few
new holes to my belt,
792
00:53:06,640 –> 00:53:09,800
so I know that something
has changed, but by how much?
793
00:53:09,800 –> 00:53:14,400
Right, the moment of truth, in which I
discovered just how much weight I have lost.
794
00:53:14,400 –> 00:53:18,360
These are a special type of scales which
are going to measure my weight accurately,
795
00:53:18,360 –> 00:53:20,280
but also, apparently, my body fat.
796
00:53:20,280 –> 00:53:23,280
Hey! That is fantastic!
797
00:53:23,280 –> 00:53:31,240
That is 173.8lb, which means
I have lost well over a stone.
798
00:53:31,240 –> 00:53:36,280
My body fat when we
did it before was 27%,
799
00:53:36,280 –> 00:53:39,440
and now it’s below 20.
800
00:53:39,440 –> 00:53:42,560
That is really, really pleasing.
801
00:53:46,280 –> 00:53:50,960
I feel good, and my
family say I look slimmer.
802
00:53:50,960 –> 00:53:54,120
It really hasn’t been that difficult,
803
00:53:54,120 –> 00:53:58,280
and I’m delighted that I’m no
longer in the overweight category.
804
00:53:58,280 –> 00:54:02,400
But what I really want to know
is what’s changed inside my body.
805
00:54:06,920 –> 00:54:12,280
Professor Luigi Fontana is about
to call with my final results.
806
00:54:12,280 –> 00:54:15,160
Hi, Michael! Hi, Luigi, how are you?
807
00:54:15,160 –> 00:54:17,680
I’m fine, and you? I’m very good.
808
00:54:17,680 –> 00:54:19,200
So, we’ve got your results.
809
00:54:19,200 –> 00:54:23,880
Just by fasting two days a
week, you made a great impact
810
00:54:23,880 –> 00:54:28,760
on your cardiometabolic health,
and so I’m very proud of you.
811
00:54:28,760 –> 00:54:33,920
‘But what’s happened to my IGF-1?
Is my body still in go-go mode?’
812
00:54:33,920 –> 00:54:38,760
IGF-1 is the major
risk factor for cancer.
813
00:54:38,760 –> 00:54:42,080
Breast cancer, prostate
cancer, colon cancer.
814
00:54:42,080 –> 00:54:45,480
Both the three-and-a-half
day fasting
815
00:54:45,480 –> 00:54:51,840
and the five weeks’ intermittent
fasting dropped your IGF-1 by 50%.
816
00:54:53,360 –> 00:54:56,600
‘Which is enough to reduce
my risk of certain cancers.
817
00:54:56,600 –> 00:55:00,240
‘But what about my blood sugar,
which was borderline diabetic?’
818
00:55:00,240 –> 00:55:05,560
Your glucose dropped
to 90. Right. Fantastic.
819
00:55:05,560 –> 00:55:07,640
So your glucose became normal again.
820
00:55:07,640 –> 00:55:10,760
‘My final result is cholesterol.’
821
00:55:10,760 –> 00:55:15,320
So, you had a reduction
in total cholesterol,
822
00:55:15,320 –> 00:55:17,840
and in an increase in
the good cholesterol.
823
00:55:17,840 –> 00:55:21,920
This shows how little
it takes, you know,
824
00:55:21,920 –> 00:55:26,160
to improve without drugs,
without taking medication.
825
00:55:26,160 –> 00:55:29,120
‘It wasn’t THAT little an effort,
826
00:55:29,120 –> 00:55:34,520
‘but I have cut my risk of developing
diseases which could shorten my life.’
827
00:55:34,520 –> 00:55:37,680
Thank you. So, I should live
happily ever after, should I?
828
00:55:37,680 –> 00:55:40,200
I don’t know if you’re
going to live happier,
829
00:55:40,200 –> 00:55:44,200
but you have a lower risk
of developing diseases.
830
00:55:44,200 –> 00:55:47,440
Thank you very much, Luigi,
really, thank you. You’re welcome.
831
00:55:47,440 –> 00:55:50,600
I’m very, very pleased.
Very pleased indeed.
832
00:55:50,600 –> 00:55:53,920
That was far better
than I was expecting.
833
00:55:55,400 –> 00:56:00,520
‘I wanted my wife Claire, who
is a GP, to share my results.’
834
00:56:00,520 –> 00:56:05,840
So, this is my IGF, which is
kind of my cancer/ageing risk.
835
00:56:05,840 –> 00:56:10,440
This one’s come down to half
on the two-day fasting. Yes.
836
00:56:10,440 –> 00:56:14,560
All of them have shown the improvement
that you, kind of, hoped for.
837
00:56:14,560 –> 00:56:15,720
Yes.
838
00:56:15,720 –> 00:56:19,040
That basically means you’re not going to
have to take tablets at all, at the moment.
839
00:56:19,040 –> 00:56:20,280
No. If you stick to it.
840
00:56:21,400 –> 00:56:24,080
Well, you’re looking good on it.
841
00:56:24,080 –> 00:56:26,160
Thank you. No, I’m really pleased.
842
00:56:26,160 –> 00:56:28,960
I have to say that’s really,
amazingly good news. Mmm.
843
00:56:33,400 –> 00:56:37,840
The results have been
absolutely fantastic for me,
844
00:56:37,840 –> 00:56:42,000
but that doesn’t mean that intermittent
fasting will work for everyone.
845
00:56:44,200 –> 00:56:48,200
It’s really important that
they do more trials on humans,
846
00:56:48,200 –> 00:56:51,320
to find out if, in the long
term, it is safe and effective.
847
00:56:53,760 –> 00:56:58,760
But having experienced intermittent
fasting, I plan to go on doing it.
848
00:56:59,880 –> 00:57:03,240
It seems to have undone
some of the damage
849
00:57:03,240 –> 00:57:05,880
that I have done to
my body down the years.
850
00:57:08,920 –> 00:57:12,040
It is very poignant looking
at the photographs of myself
851
00:57:12,040 –> 00:57:15,160
and members of my family
growing up and growing older,
852
00:57:15,160 –> 00:57:18,640
but it doesn’t make me want
to hold back the hands of time.
853
00:57:18,640 –> 00:57:23,920
I sort of think that we do
grow old, we should grow old,
854
00:57:23,920 –> 00:57:26,920
and there’s very little
we can do about it.
855
00:57:26,920 –> 00:57:31,680
But fasting is somehow different. Fasting
is not about trying to live to 140,
856
00:57:31,680 –> 00:57:35,880
it’s about staying healthy
for as long as you can,
857
00:57:35,880 –> 00:57:39,280
and with the sort of time
bomb we’re facing as a nation,
858
00:57:39,280 –> 00:57:42,240
with obesity going
up, diabetes going up,
859
00:57:42,240 –> 00:57:45,960
we desperately need something
which can make a difference.
860
00:57:45,960 –> 00:57:49,480
Fasting is the first
thing I’ve come across
861
00:57:49,480 –> 00:57:52,840
that I genuinely believe that
if people were to take it up,
862
00:57:52,840 –> 00:57:56,840
it could radically transform
the nation’s health.
863
00:57:56,840 –> 00:58:03,360
So, I hope that we continue to see
massive research going into this territory.
864
00:58:04,560 –> 00:58:08,240
Doing this fasting has been
one of the most interesting…
865
00:58:08,240 –> 00:58:11,600
no, I would say THE most
interesting sort of journey, film,
866
00:58:11,600 –> 00:58:14,240
whatever you want to call
it, that I have been on.
867
00:58:14,240 –> 00:58:16,320
DOG WHIMPERS
868
00:58:16,320 –> 00:58:18,520
And I’ve never said that before.
869
00:58:32,000 –> 00:58:35,640
Subtitles by Jozef Jarosciak
